ES2149354T3 - Solucion acuosa, estable de folinato. - Google Patents
Solucion acuosa, estable de folinato.Info
- Publication number
- ES2149354T3 ES2149354T3 ES95913428T ES95913428T ES2149354T3 ES 2149354 T3 ES2149354 T3 ES 2149354T3 ES 95913428 T ES95913428 T ES 95913428T ES 95913428 T ES95913428 T ES 95913428T ES 2149354 T3 ES2149354 T3 ES 2149354T3
- Authority
- ES
- Spain
- Prior art keywords
- stable
- aqueous
- folinate
- folinate solution
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
LA INVENCION PROPORCIONA UN SOLUCION ACUOSA DE FOLINATO APROPIADA PARA APLICACIONES MEDICAS EN FORMA DE SOLUCION DE FOLINATO SODICO QUE ES ESTABLE CUANDO ES ALMACENADA A TEMPERATURAS DE REFRIGERADOR, P.E. NO CRISTALIZA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL9400530A NL9400530A (nl) | 1994-04-05 | 1994-04-05 | Stabiele waterige folinaatoplossing. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2149354T3 true ES2149354T3 (es) | 2000-11-01 |
Family
ID=19864026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95913428T Expired - Lifetime ES2149354T3 (es) | 1994-04-05 | 1995-04-04 | Solucion acuosa, estable de folinato. |
Country Status (15)
Country | Link |
---|---|
US (1) | US6613767B1 (es) |
EP (1) | EP0755396B1 (es) |
JP (1) | JPH09510989A (es) |
AT (1) | ATE194346T1 (es) |
AU (1) | AU684350B2 (es) |
DE (1) | DE69517806T2 (es) |
DK (1) | DK0755396T3 (es) |
ES (1) | ES2149354T3 (es) |
FI (1) | FI120039B (es) |
GR (1) | GR3033863T3 (es) |
NL (1) | NL9400530A (es) |
NO (1) | NO314039B1 (es) |
PT (1) | PT755396E (es) |
WO (1) | WO1995026963A1 (es) |
ZA (1) | ZA952805B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH687062A5 (de) * | 1994-02-14 | 1996-09-13 | Cerbios Pharma Sa | Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten. |
NL9400530A (nl) | 1994-04-05 | 1995-11-01 | Pharmachemie Bv | Stabiele waterige folinaatoplossing. |
CH697021A5 (de) * | 2003-06-26 | 2008-03-31 | Merck Eprova Ag | Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat. |
CH696717A5 (de) * | 2004-02-20 | 2007-10-31 | Cerbios Pharma Sa | Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt |
CN102258463A (zh) * | 2011-07-18 | 2011-11-30 | 重庆煜澍丰医药有限公司 | 一种稳定的亚叶酸钠注射液 |
ES2414557B1 (es) * | 2012-01-16 | 2014-06-10 | Novocat Farma, S.A. | Composición acuosa de paracetamol para inyección |
WO2014025807A1 (en) | 2012-08-06 | 2014-02-13 | Spectrum Pharmaceuticals, Inc. | Pharmaceutical compositions comprising l-leucovorin |
US10059710B2 (en) | 2016-02-17 | 2018-08-28 | Merck & Cie | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2695860A (en) * | 1952-04-29 | 1954-11-30 | American Cyanamid Co | Stabilized pteroyl solutions |
CH673459A5 (es) | 1987-05-15 | 1990-03-15 | Eprova Ag | |
WO1990010460A1 (en) | 1989-03-13 | 1990-09-20 | Kenneth Naoyuki Matsumura | Method for reducing side effects of a drug |
NL8901432A (nl) * | 1989-06-06 | 1991-01-02 | Pharmachemie Bv | Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan. |
US5173488A (en) * | 1989-08-21 | 1992-12-22 | American Cyanamid Company | Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method |
CH687062A5 (de) | 1994-02-14 | 1996-09-13 | Cerbios Pharma Sa | Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten. |
NL9400530A (nl) | 1994-04-05 | 1995-11-01 | Pharmachemie Bv | Stabiele waterige folinaatoplossing. |
-
1994
- 1994-04-05 NL NL9400530A patent/NL9400530A/nl not_active Application Discontinuation
-
1995
- 1995-04-04 AT AT95913428T patent/ATE194346T1/de active
- 1995-04-04 JP JP7525589A patent/JPH09510989A/ja active Pending
- 1995-04-04 ES ES95913428T patent/ES2149354T3/es not_active Expired - Lifetime
- 1995-04-04 EP EP95913428A patent/EP0755396B1/en not_active Expired - Lifetime
- 1995-04-04 PT PT95913428T patent/PT755396E/pt unknown
- 1995-04-04 DE DE69517806T patent/DE69517806T2/de not_active Expired - Lifetime
- 1995-04-04 DK DK95913428T patent/DK0755396T3/da active
- 1995-04-04 AU AU20862/95A patent/AU684350B2/en not_active Expired
- 1995-04-04 WO PCT/NL1995/000126 patent/WO1995026963A1/en active IP Right Grant
- 1995-04-05 ZA ZA952805A patent/ZA952805B/xx unknown
-
1996
- 1996-10-03 FI FI963972A patent/FI120039B/fi not_active IP Right Cessation
- 1996-10-04 NO NO19964231A patent/NO314039B1/no not_active IP Right Cessation
- 1996-10-07 US US08/726,803 patent/US6613767B1/en not_active Expired - Lifetime
-
2000
- 2000-07-06 GR GR20000401477T patent/GR3033863T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US6613767B1 (en) | 2003-09-02 |
EP0755396B1 (en) | 2000-07-05 |
WO1995026963A1 (en) | 1995-10-12 |
NO314039B1 (no) | 2003-01-20 |
DE69517806T2 (de) | 2001-11-08 |
JPH09510989A (ja) | 1997-11-04 |
AU684350B2 (en) | 1997-12-11 |
NO964231L (no) | 1996-10-04 |
FI120039B (fi) | 2009-06-15 |
GR3033863T3 (en) | 2000-10-31 |
DK0755396T3 (da) | 2000-11-13 |
AU2086295A (en) | 1995-10-23 |
EP0755396A1 (en) | 1997-01-29 |
FI963972A (fi) | 1996-10-03 |
PT755396E (pt) | 2000-10-31 |
FI963972A0 (fi) | 1996-10-03 |
ATE194346T1 (de) | 2000-07-15 |
DE69517806D1 (de) | 2000-08-10 |
ZA952805B (en) | 1995-12-19 |
NL9400530A (nl) | 1995-11-01 |
NO964231D0 (no) | 1996-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Grant refused |
Effective date: 19981020 |
|
FG2A | Definitive protection |
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