ES2146227T3 - Composiciones farmaceuticas que contienen nifedipina y procedimiento para su preparacion. - Google Patents

Composiciones farmaceuticas que contienen nifedipina y procedimiento para su preparacion.

Info

Publication number
ES2146227T3
ES2146227T3 ES93901850T ES93901850T ES2146227T3 ES 2146227 T3 ES2146227 T3 ES 2146227T3 ES 93901850 T ES93901850 T ES 93901850T ES 93901850 T ES93901850 T ES 93901850T ES 2146227 T3 ES2146227 T3 ES 2146227T3
Authority
ES
Spain
Prior art keywords
pct
nifedipine
pharmaceutical compositions
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93901850T
Other languages
English (en)
Inventor
David Trigger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethical Pharmaceuticals UK Ltd
Original Assignee
Ethical Pharmaceuticals UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethical Pharmaceuticals UK Ltd filed Critical Ethical Pharmaceuticals UK Ltd
Application granted granted Critical
Publication of ES2146227T3 publication Critical patent/ES2146227T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PROPORCIONAN LOS COMPUESTOS Y LOS PROCESOS PARA SU PREPARACION EN LOS QUE LA NIFEDIPINA ESTA ENCUBIERTA SOBRE UN TRANSPORTADOR SOLUBLE EN AGUA EN UNA MEZCLA CON POLIVINILOPIRROLIDON O UN COPOLIMERO DE N Y UN POLIMERO DE BASE ACRILICA ACEPTABLE FARMACEUTICAMENTE. LA RAZON DE POLIVINILOPIRROLIDON O COPOLIMERO N ON / ACETATO DE VINILO AL CONTENIDO DE NIFEDIPINA ESTA EN LA PROPORCION DE ENTRE 1:1 A 1:10 Y LA RAZON DEL POLIMERO DE BASE ACRILICA AL CONTENIDO DE NIFEDIPINA ESTA EN LA PROPORCION DE ENTRE 1:4 A 1:20. SE PROPORCIONAN LOS COMPUESTOS ADECUADOS PARA UNA ADMINISTRACION DE NIFEDIPINA UNA VEZ AL DIA.
ES93901850T 1992-01-13 1993-01-12 Composiciones farmaceuticas que contienen nifedipina y procedimiento para su preparacion. Expired - Lifetime ES2146227T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929200607A GB9200607D0 (en) 1992-01-13 1992-01-13 Pharmaceutical compositions containing nifedipine and process for the preparation thereof

Publications (1)

Publication Number Publication Date
ES2146227T3 true ES2146227T3 (es) 2000-08-01

Family

ID=10708487

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93901850T Expired - Lifetime ES2146227T3 (es) 1992-01-13 1993-01-12 Composiciones farmaceuticas que contienen nifedipina y procedimiento para su preparacion.

Country Status (24)

Country Link
US (1) US5594013A (es)
EP (1) EP0620733B1 (es)
JP (1) JPH07503003A (es)
AT (1) ATE191144T1 (es)
AU (1) AU659529B2 (es)
CA (1) CA2126864A1 (es)
DE (2) DE4390075T1 (es)
DK (2) DK0620733T3 (es)
ES (1) ES2146227T3 (es)
FI (1) FI943316A (es)
GB (2) GB9200607D0 (es)
HU (2) HU219338B (es)
IS (1) IS1620B (es)
MY (1) MY110660A (es)
NL (1) NL9320021A (es)
NO (1) NO305223B1 (es)
NZ (1) NZ246374A (es)
PH (1) PH30985A (es)
PL (1) PL170935B1 (es)
PT (1) PT620733E (es)
RU (1) RU2106139C1 (es)
SE (1) SE9402457L (es)
WO (1) WO1993013773A1 (es)
ZA (1) ZA93195B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005262A1 (en) * 1992-09-10 1994-03-17 F.H. Faulding & Co. Limited Sustained release matrix composition
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5773025A (en) * 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5871776A (en) * 1995-01-31 1999-02-16 Mehta; Atul M. Controlled-release nifedipine
EP0952770A4 (en) * 1995-09-07 1999-12-22 Fuisz Technologies Ltd SYSTEM FOR MAKING SUBSTANTIALLY NON-SOLUBLE BIOALTERANT AGENTS BIOAVAILABLE
CO4771151A1 (es) * 1996-01-19 1999-04-30 Rachitzky Falicman Pablo Alberto Procedimiento para la elaboracion de una preparacion farmace utica que contiene nifedipina y la preparacion farmaceutica obtenida mediante el mismo
AU695734B2 (en) * 1996-07-08 1998-08-20 Penwest Pharmaceuticals Co. Sustained release matrix for high-dose insoluble drugs
IT1284604B1 (it) * 1996-09-27 1998-05-21 Roberto Valducci Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva
US5837379A (en) * 1997-01-31 1998-11-17 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
US5922352A (en) * 1997-01-31 1999-07-13 Andrx Pharmaceuticals, Inc. Once daily calcium channel blocker tablet having a delayed release core
US6056977A (en) 1997-10-15 2000-05-02 Edward Mendell Co., Inc. Once-a-day controlled release sulfonylurea formulation
US6485748B1 (en) 1997-12-12 2002-11-26 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
US6264872B1 (en) 1997-12-30 2001-07-24 Kimberly-Clark Worldwide, Inc. Method of forming thin, embossed, textured barrier films
US6969529B2 (en) 2000-09-21 2005-11-29 Elan Pharma International Ltd. Nanoparticulate compositions comprising copolymers of vinyl pyrrolidone and vinyl acetate as surface stabilizers
US6706283B1 (en) 1999-02-10 2004-03-16 Pfizer Inc Controlled release by extrusion of solid amorphous dispersions of drugs
US6168806B1 (en) 1999-03-05 2001-01-02 Fang-Yu Lee Orally administrable nifedipine pellet and process for the preparation thereof
JP4541647B2 (ja) * 2000-11-20 2010-09-08 エラン ファーマ インターナショナル，リミティド 表面安定剤として共重合体を含むナノ粒子組成物
SE0100200D0 (sv) * 2001-01-24 2001-01-24 Astrazeneca Ab New film coating
SK9132003A3 (en) * 2001-12-19 2004-02-03 Astrazeneca Ab A film coating composition, a coating film, pharmaceutical formulation comprising same and a process for its production
US6620900B2 (en) * 2002-02-07 2003-09-16 Isp Investments Inc. Proliferous copolymer of vinyl pyrrolidone and vinyl acetate
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
WO2004026361A1 (en) * 2002-09-18 2004-04-01 Medtronic Vascular, Inc. Controllable drug releasing gradient coatings for medical devices
EP1874274A2 (en) * 2005-04-06 2008-01-09 Mallinckrodt Inc. Matrix-based pulse release pharmaceutical formulation
WO2007106111A2 (en) * 2005-07-01 2007-09-20 Elan Pharma International Limited Nanoparticulate and controlled release compositions comprising nilvadipine
JP5351490B2 (ja) * 2007-10-25 2013-11-27 バイエル薬品株式会社 ニフェジピン含有有核錠剤およびその製法
RU2629843C1 (ru) * 2016-05-24 2017-09-04 федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) Способ получения мази нифедипина (варианты)

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2400819C2 (de) * 1974-01-09 1982-04-22 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
EP0001247A1 (en) * 1977-09-14 1979-04-04 Kanebo, Ltd. Pharmaceutical preparation containing nifedipine and a method for producing the same.
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
EP0047894B2 (en) * 1980-09-05 1990-09-05 Argus Chemical Corporation Homogeneous storage-stable liquid barium-cadmium-triphosphite stabilizer systems for polyvinyl chloride resins
DE3033919A1 (de) * 1980-09-09 1982-04-22 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung
JPS5846019A (ja) * 1981-09-14 1983-03-17 Kanebo Ltd 持続性ニフエジピン製剤
DE3270785D1 (en) * 1981-10-29 1986-05-28 Bayer Ag Process for preparing solid fast-releasing drug formulations of dihydropyridines
DE3580384D1 (de) * 1984-04-09 1990-12-13 Toyo Boseki Praeparat mit verzoegerter freigabe zum aufbringen auf die schleimhaeute der mundhoehle.
DE3424553A1 (de) * 1984-07-04 1986-01-09 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung
IT1178511B (it) * 1984-09-14 1987-09-09 Pharmatec Spa Procedimento per la preparazione di una forma solida per uso orale a base di nifedipina con rilascio
DE3438830A1 (de) * 1984-10-23 1986-04-30 Rentschler Arzneimittel Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung
FR2579510B1 (fr) * 1985-03-29 1989-12-15 Demler Sa Ets Table vibrante pour la fabrication de produits en beton
FR2585174B1 (fr) * 1985-07-16 1987-11-27 Eurofarad Procede de fabrication d'un composant capacitif multicouche a dielectrique ceramique du type cordierite, et composant ainsi obtenu
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
SE8601624D0 (sv) * 1986-04-11 1986-04-11 Haessle Ab New pharmaceutical preparations
GB8613689D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
US4970075A (en) * 1986-07-18 1990-11-13 Euroceltique, S.A. Controlled release bases for pharmaceuticals
IE59540B1 (en) * 1987-01-09 1994-03-09 Elan Corp Sustained release capsule or tablet formulation
US4968508A (en) * 1987-02-27 1990-11-06 Eli Lilly And Company Sustained release matrix
GB8722306D0 (en) * 1987-09-22 1987-10-28 Aps Research Ltd Sustained-release formulation
GB8903328D0 (en) * 1989-02-14 1989-04-05 Ethical Pharma Ltd Nifedipine-containing pharmaceutical compositions and process for the preparation thereof
ATE124864T1 (de) * 1989-03-10 1995-07-15 Yamanouchi Pharma Co Ltd Die wirkstoffabgabe steuerndes überzugsmaterial für lang wirksame formulierungen.
HU203041B (en) * 1989-03-14 1991-05-28 Egyt Gyogyszervegyeszeti Gyar Process for producing pharmaceutical compositions of controlled releasing factor containing nifedipin
JPH0729926B2 (ja) * 1989-07-25 1995-04-05 大塚製薬株式会社 易吸収性製剤用組成物

Also Published As

Publication number Publication date
NO942622D0 (no) 1994-07-12
JPH07503003A (ja) 1995-03-30
FI943316A0 (fi) 1994-07-12
WO1993013773A1 (en) 1993-07-22
DE69328245D1 (de) 2000-05-04
IS1620B (is) 1996-10-18
DE4390075T1 (de) 1994-12-01
GB2277872B (en) 1995-10-04
HUT67426A (en) 1995-04-28
GB9413101D0 (en) 1994-08-31
PL300638A1 (en) 1994-03-21
ATE191144T1 (de) 2000-04-15
NO942622L (no) 1994-07-12
HU9401850D0 (en) 1994-09-28
RU94035739A (ru) 1996-09-20
GB2277872A (en) 1994-11-16
GB9200607D0 (en) 1992-03-11
ZA93195B (en) 1993-08-16
US5594013A (en) 1997-01-14
AU3263693A (en) 1993-08-03
HU219338B (en) 2001-03-28
CA2126864A1 (en) 1993-07-22
MY110660A (en) 1999-01-30
PT620733E (pt) 2000-08-31
NO305223B1 (no) 1999-04-26
FI943316A (fi) 1994-07-12
PL170935B1 (pl) 1997-02-28
DE69328245T2 (de) 2000-10-12
EP0620733B1 (en) 2000-03-29
AU659529B2 (en) 1995-05-18
DK83794A (da) 1994-07-11
HU210539A9 (en) 1995-05-29
NL9320021A (nl) 1995-06-01
EP0620733A1 (en) 1994-10-26
RU2106139C1 (ru) 1998-03-10
PH30985A (en) 1997-12-23
NZ246374A (en) 1995-07-26
DK0620733T3 (da) 2000-07-24
SE9402457D0 (sv) 1994-07-12
IS3966A (is) 1993-07-14
SE9402457L (sv) 1994-09-12

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