ES2144414T3 - Control de la expresion de un gen por medio de una radiacion ionizante. - Google Patents
Control de la expresion de un gen por medio de una radiacion ionizante.Info
- Publication number
- ES2144414T3 ES2144414T3 ES92903431T ES92903431T ES2144414T3 ES 2144414 T3 ES2144414 T3 ES 2144414T3 ES 92903431 T ES92903431 T ES 92903431T ES 92903431 T ES92903431 T ES 92903431T ES 2144414 T3 ES2144414 T3 ES 2144414T3
- Authority
- ES
- Spain
- Prior art keywords
- expression
- tissues
- gene
- ionizing radiation
- control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0023—Agression treatment or altering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA INVENCION SE REFIERE A ESTRUCTURAS GENETICAS QUE COMPRENDEN UNA ZONA PROMOTORA-REFORZADORA QUE ES RESPONSABLE DE LA RADIACION Y POR LO MENOS UN GENE ESTRUCTURAL CUYA EXPRESION ESTA CONTROLADA POR EL PROMOTOR-REFORZADOR. ESTA INVENCION TAMBIEN SE REFIERE A METODOS DE DESTRUCION, ALTERACION O INACTIVACION DE CELULAS EN TEJIDO OBJETIVO POR SUMINISTRO DE LA ESTRUCTURA GENETICA A LAS CELULAS DE LOS TEJIDOS E INDUCCION DE LA EXPRESION DEL GENE O GENES ESTRUCTURALES EN LA ESTRUCTURA, POR EXPOSICION DE LOS TEJIDOS A LA RADIACION IONIZANTE. ESTA INVENCION ES UTIL PARA EL TRATAMIENTO DE PACIENTES CON CANCER, TRASTORNOS DE COAGULACION, INFARTO DE MIOCARDIO Y OTRAS ENFERMEDADES PARA LAS CUALES LOS TEJIDOS OBJETIVOS PUEDEN SER IDENTIFICADOS Y PARA LAS CUALES LA EXPRESION DEL GENE DE LA ESTRUCTURA DENTRO DEL TEJIDO OBJETIVO PUEDE ALIVIAR LA ENFERMEDAD O TRASTORNO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63362690A | 1990-12-20 | 1990-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2144414T3 true ES2144414T3 (es) | 2000-06-16 |
Family
ID=24540424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92903431T Expired - Lifetime ES2144414T3 (es) | 1990-12-20 | 1991-12-19 | Control de la expresion de un gen por medio de una radiacion ionizante. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5612318A (es) |
EP (1) | EP0563278B1 (es) |
JP (1) | JP3337214B2 (es) |
AT (1) | ATE190354T1 (es) |
AU (1) | AU657111B2 (es) |
CA (1) | CA2098849C (es) |
DE (1) | DE69132031T2 (es) |
DK (1) | DK0563278T3 (es) |
ES (1) | ES2144414T3 (es) |
WO (1) | WO1992011033A1 (es) |
Families Citing this family (108)
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---|---|---|---|---|
US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US20020150539A1 (en) * | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
CA2098849C (en) * | 1990-12-20 | 2007-07-10 | Ralph R. Weichselbaum | Control of gene expression by ionizing radiation |
US6605712B1 (en) * | 1990-12-20 | 2003-08-12 | Arch Development Corporation | Gene transcription and ionizing radiation: methods and compositions |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
US5811231A (en) * | 1993-01-21 | 1998-09-22 | Pres. And Fellows Of Harvard College | Methods and kits for eukaryotic gene profiling |
US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
AUPM322393A0 (en) * | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
US7592317B1 (en) | 1994-08-11 | 2009-09-22 | The University Of Chicago | Constitutive gene expression in conjuction with ionizing radiation |
US8021667B2 (en) | 1994-11-16 | 2011-09-20 | Macfarlane Burnet Institute For Medical Research And Public Health Ltd | Compositions for immunotherapy and uses thereof |
US6548643B1 (en) | 1994-11-16 | 2003-04-15 | Austin Research Institute | Antigen carbohydrate compounds and their use in immunotherapy |
US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
US5962424A (en) * | 1995-02-21 | 1999-10-05 | Arch Development Corporation | Methods and compositions for targeting selectins |
WO1996027021A1 (en) * | 1995-03-01 | 1996-09-06 | Cornell Research Foundation, Inc. | Interdependent adenoviral vectors and methods of using same |
US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
CA2191903A1 (en) * | 1995-12-20 | 1997-06-21 | Jun Ikeda | Stress proteins |
JP2001507207A (ja) | 1996-05-01 | 2001-06-05 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | 化合物を細胞に送達する方法 |
US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
ES2189974T3 (es) | 1996-09-11 | 2003-07-16 | Imarx Pharmaceutical Corp | Procedimientos mejorados para la obtencion de imagenes de diagnostico usando un agente de contraste y un vasodilatador. |
US6544523B1 (en) | 1996-11-13 | 2003-04-08 | Chiron Corporation | Mutant forms of Fas ligand and uses thereof |
KR20000076115A (ko) * | 1997-03-10 | 2000-12-26 | 와일러 제임스 에프. | 이종 유전자의 일시적이고 선택적인 발현을 위한 산화 스트레스를 생성하는 광역학적 치료요법 |
CA2283461A1 (en) * | 1997-03-14 | 1998-09-17 | Uab Research Foundation | Adenoviral vectors with modified tropism |
US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
US6537246B1 (en) * | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
US20050019266A1 (en) * | 1997-05-06 | 2005-01-27 | Unger Evan C. | Novel targeted compositions for diagnostic and therapeutic use |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
WO1999016455A1 (en) | 1997-09-29 | 1999-04-08 | The Austin Research Institute | Mannose receptor bearing cell line and antigen composition |
CA2671261A1 (en) | 1997-11-06 | 1999-05-20 | Novartis Vaccines And Diagnostics S.R.L. | Neisserial antigens |
WO1999025385A1 (en) * | 1997-11-17 | 1999-05-27 | Imarx Pharmaceutical Corp. | A method of increasing nucleic acid synthesis with ultrasound |
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US6380393B1 (en) | 1999-03-19 | 2002-04-30 | San Diego State University Foundation | Ligands, transition metal complexes and methods of using same |
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US8034791B2 (en) | 2001-04-06 | 2011-10-11 | The University Of Chicago | Activation of Egr-1 promoter by DNA damaging chemotherapeutics |
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US5206152A (en) * | 1988-04-08 | 1993-04-27 | Arch Development Corporation | Cloning and expression of early growth regulatory protein genes |
CA2098849C (en) * | 1990-12-20 | 2007-07-10 | Ralph R. Weichselbaum | Control of gene expression by ionizing radiation |
US5571797A (en) * | 1994-05-11 | 1996-11-05 | Arch Development Corporation | Method of inducing gene expression by ionizing radiation |
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1991
- 1991-12-19 CA CA002098849A patent/CA2098849C/en not_active Expired - Fee Related
- 1991-12-19 WO PCT/US1991/009651 patent/WO1992011033A1/en active IP Right Grant
- 1991-12-19 DK DK92903431T patent/DK0563278T3/da active
- 1991-12-19 JP JP50340392A patent/JP3337214B2/ja not_active Expired - Lifetime
- 1991-12-19 ES ES92903431T patent/ES2144414T3/es not_active Expired - Lifetime
- 1991-12-19 AU AU91702/91A patent/AU657111B2/en not_active Ceased
- 1991-12-19 EP EP92903431A patent/EP0563278B1/en not_active Expired - Lifetime
- 1991-12-19 AT AT92903431T patent/ATE190354T1/de not_active IP Right Cessation
- 1991-12-19 DE DE69132031T patent/DE69132031T2/de not_active Expired - Fee Related
-
1994
- 1994-03-14 US US08/212,308 patent/US5612318A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/486,338 patent/US5817636A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0563278A1 (en) | 1993-10-06 |
ATE190354T1 (de) | 2000-03-15 |
CA2098849A1 (en) | 1992-06-21 |
AU657111B2 (en) | 1995-03-02 |
DE69132031D1 (de) | 2000-04-13 |
AU9170291A (en) | 1992-07-22 |
US5612318A (en) | 1997-03-18 |
EP0563278A4 (es) | 1994-02-02 |
WO1992011033A1 (en) | 1992-07-09 |
EP0563278B1 (en) | 2000-03-08 |
DE69132031T2 (de) | 2000-07-13 |
CA2098849C (en) | 2007-07-10 |
DK0563278T3 (da) | 2000-08-21 |
US5817636A (en) | 1998-10-06 |
JPH06506194A (ja) | 1994-07-14 |
JP3337214B2 (ja) | 2002-10-21 |
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