ES2138639T3 - Derivados peptidicos de tetrahidronaftaleno. - Google Patents

Derivados peptidicos de tetrahidronaftaleno.

Info

Publication number
ES2138639T3
ES2138639T3 ES94112544T ES94112544T ES2138639T3 ES 2138639 T3 ES2138639 T3 ES 2138639T3 ES 94112544 T ES94112544 T ES 94112544T ES 94112544 T ES94112544 T ES 94112544T ES 2138639 T3 ES2138639 T3 ES 2138639T3
Authority
ES
Spain
Prior art keywords
image
configuration
amino acid
alpha
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94112544T
Other languages
English (en)
Inventor
Christine Abrecht
Klaus Muller
Daniel Obrecht
Arnold Trzeciak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2138639T3 publication Critical patent/ES2138639T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DERIVADO PEPTIDO TETRAHIDRONAFTALINA DE LA FORMULA GENERAL DONDE R1 SIGNIFICA HIDROGENO, BROMO, CIANO, FORMIL, HIDROXI, ALQUIL INFERIOR, ALQUENIL INFERIOR, ALQUINIL INFERIOR, ALCOXI INFERIOR, ARILOXI, ARALCOXI INFERIOR O ARIL; R2 ES UNA CADENA EVENTUALMENTE PROTEGIDA DE HASTA 20 ESTERES AMINOACIDOS, CUYO AMINOACIDO C GIDO O EN FORMA DE UNA AMIDA; A1, A2, A3 Y A4 SON RESPECTIVAMENTE RESTOS DE ALFA ES NO SIMETRICO, ESTA PRESENTE EN A1 Y A2 EN LA CONFIGURACION L Y EN A3 Y EN A4 EN LA CONFIGURACION D; X SIGNIFICA HIDROGENO O AZUFRE; Y Y CONJUNTAMENTE CON AMBOS ATOMOS DE C SIGNIFICAN UN ANILLO BENZOL, URANO, TIOFENO, PIRIDINA O ANILLO PIRIDINA EVENTUALMENTE SUSTITUIDOS. ASI COMO SUS SALES ESPECIALMENTE AQUELLAS QUE NO CONTIENEN NINGUN GRUPO O GRUPOS DE PROTECCION. SON AGENTES AUXILIARES VALIOSOS PARA LA DETERMINACION DE LAS SECUENCIAS PEPTIDAS BIOLOGICAMENTE ACTIVAS Y REPRESENTAN CON ELLO "RESERCH TOOLS" CONOCIDAS; QUE SON TAMBIEN SIN EMBARGO APROPIADOS DE FORMA POTENCIAL COMO MEDICAMENTOS.
ES94112544T 1993-08-27 1994-08-11 Derivados peptidicos de tetrahidronaftaleno. Expired - Lifetime ES2138639T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH255293 1993-08-27

Publications (1)

Publication Number Publication Date
ES2138639T3 true ES2138639T3 (es) 2000-01-16

Family

ID=4236370

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94112544T Expired - Lifetime ES2138639T3 (es) 1993-08-27 1994-08-11 Derivados peptidicos de tetrahidronaftaleno.

Country Status (7)

Country Link
US (1) US5644024A (es)
EP (1) EP0640618B1 (es)
JP (1) JPH0789987A (es)
AT (1) ATE185813T1 (es)
DE (1) DE59408838D1 (es)
DK (1) DK0640618T3 (es)
ES (1) ES2138639T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0729972A1 (de) * 1995-02-28 1996-09-04 F. Hoffmann-La Roche Ag Tetrahydronaphthalin-Peptidderivate
GB9509156D0 (en) 1995-05-05 1995-06-28 Sandoz Ltd Organic compounds
WO2003004149A1 (fr) * 2001-07-06 2003-01-16 Daicel Chemical Industries, Ltd. Agent de separation d'isomere optique et procede de preparation de cet agent
ES2739433T3 (es) 2013-09-09 2020-01-31 Peloton Therapeutics Inc Aril éteres y usos de los mismos
WO2016144825A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Aromatic compounds and uses thereof
WO2016145045A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Compositions for use in treating glioblastoma
EP3267792A4 (en) 2015-03-11 2018-09-26 Peloton Therapeutics, Inc. Compositions for use in treating pulmonary arterial hypertension
EP3268362B1 (en) 2015-03-11 2021-10-20 Peloton Therapeutics, Inc. Substituted pyridines and uses thereof
US10335388B2 (en) 2015-04-17 2019-07-02 Peloton Therapeutics, Inc. Combination therapy of a HIF-2-alpha inhibitor and an immunotherapeutic agent and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2101599A1 (en) * 1992-08-31 1994-03-01 Wilhelm Bannwarth Tri- and tetracyclic compounds

Also Published As

Publication number Publication date
EP0640618A1 (de) 1995-03-01
DK0640618T3 (da) 2000-04-03
ATE185813T1 (de) 1999-11-15
DE59408838D1 (de) 1999-11-25
US5644024A (en) 1997-07-01
EP0640618B1 (de) 1999-10-20
JPH0789987A (ja) 1995-04-04

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