ES2137888B1 - ANTIFUNGIC AGENT, COMPOSED FOR THE SAME PROCEDURE FOR ITS PRODUCTION AND METHOD FOR USE. - Google Patents
ANTIFUNGIC AGENT, COMPOSED FOR THE SAME PROCEDURE FOR ITS PRODUCTION AND METHOD FOR USE.Info
- Publication number
- ES2137888B1 ES2137888B1 ES009750013A ES9750013A ES2137888B1 ES 2137888 B1 ES2137888 B1 ES 2137888B1 ES 009750013 A ES009750013 A ES 009750013A ES 9750013 A ES9750013 A ES 9750013A ES 2137888 B1 ES2137888 B1 ES 2137888B1
- Authority
- ES
- Spain
- Prior art keywords
- production
- same procedure
- antifungic
- agent
- antifungic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19617495 | 1995-07-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2137888A1 ES2137888A1 (en) | 1999-12-16 |
ES2137888B1 true ES2137888B1 (en) | 2001-01-01 |
Family
ID=16353435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009750013A Expired - Fee Related ES2137888B1 (en) | 1995-07-08 | 1996-07-05 | ANTIFUNGIC AGENT, COMPOSED FOR THE SAME PROCEDURE FOR ITS PRODUCTION AND METHOD FOR USE. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5900488A (en) |
EP (1) | EP0839035B1 (en) |
KR (1) | KR100386491B1 (en) |
CN (1) | CN1091596C (en) |
AT (1) | AT407832B (en) |
CA (1) | CA2226214C (en) |
CH (1) | CH692045A5 (en) |
DE (1) | DE19681478B4 (en) |
DK (1) | DK176599B1 (en) |
ES (1) | ES2137888B1 (en) |
FI (1) | FI119357B (en) |
GB (1) | GB2317615B (en) |
HK (1) | HK1009751A1 (en) |
IL (1) | IL122618A (en) |
IN (1) | IN185384B (en) |
LU (1) | LU90190B1 (en) |
NO (1) | NO980055L (en) |
NZ (1) | NZ311796A (en) |
SE (1) | SE9800016D0 (en) |
TW (1) | TW450969B (en) |
WO (1) | WO1997002821A2 (en) |
ZA (1) | ZA965745B (en) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6127397A (en) * | 1996-12-10 | 2000-10-03 | Nihon Nohyaku Co., Ltd. | Optically active (R)-(E)-(4-substituted-phenyl-1,3-dithiolan-2-ylidene)-1-imidazolylaceto nitrile derivative, antifungal composition comprising the same, and method for producing the same |
AU2003242235A1 (en) * | 2002-06-18 | 2003-12-31 | Pola Chemical Industries Inc. | Antifungal medicinal composition |
US8039452B2 (en) | 2002-06-18 | 2011-10-18 | Pola Pharma Inc. | Antifungal medicinal compositions |
EP2025337B1 (en) * | 2006-03-08 | 2014-09-10 | Nihon Nohyaku Co., Ltd. | Pharmaceutical composition for external use |
CA2645070C (en) | 2006-03-08 | 2014-02-04 | Nihon Nohyaku Co., Ltd. | Pharmaceutical composition for external use |
RU2415669C2 (en) | 2006-03-08 | 2011-04-10 | Нихон Нохияку Ко., Лтд. | Pharmaceutic composition for external application |
ES2588188T3 (en) * | 2007-08-27 | 2016-10-31 | Nihon Nohyaku Co., Ltd. | Agent for fungal dermatitis |
JP5453093B2 (en) | 2007-09-05 | 2014-03-26 | 株式会社ポーラファルマ | Antifungal pharmaceutical composition |
CN101808637B (en) * | 2007-09-05 | 2013-07-24 | 宝丽制药股份有限公司 | Pharmaceutical composition |
KR20100075476A (en) | 2007-09-05 | 2010-07-02 | 가부시키가이샤 폴라 파마 | Antifungal composition |
WO2010093992A1 (en) * | 2009-02-13 | 2010-08-19 | Topica Pharmaceuticals, Inc | Anti-fungal formulation |
EP2416757A2 (en) | 2009-04-09 | 2012-02-15 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
KR101409792B1 (en) | 2009-04-09 | 2014-06-19 | 니혼노야쿠가부시키가이샤 | Antimycotic pharmaceutical composition |
KR101754697B1 (en) | 2009-08-25 | 2017-07-06 | 가부시키가이샤 폴라 파마 | Antimycotic pharmaceutical composition |
WO2011155640A1 (en) * | 2010-06-11 | 2011-12-15 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
CN103012385B (en) * | 2012-02-17 | 2015-07-08 | 山东威智医药工业有限公司 | Crystal form of luliconazole and preparation method thereof |
JP5460797B1 (en) | 2012-09-14 | 2014-04-02 | 株式会社ポーラファルマ | Amide derivatives and their use as stability indicators |
WO2014042231A1 (en) * | 2012-09-14 | 2014-03-20 | Pola Pharma Inc. | Crystal and pharmaceutical preparation containing the same crystal |
CN104619704B (en) * | 2012-09-14 | 2017-12-05 | 宝丽制药股份有限公司 | Surface free energy is used for the purposes for breaking up evaluation crystal, the crystal based on surface free energy as metrics evaluation, and the pharmaceutical composition by being prepared comprising the crystal |
US9199977B2 (en) * | 2012-09-14 | 2015-12-01 | Pola Pharma Inc. | Crystal having crystal habits and pharmaceutical composition obtained by processing the crystal |
US20150366845A1 (en) * | 2013-01-28 | 2015-12-24 | Pola Pharma Inc., | Pharmaceutical composition for diseases caused by pathogenic microorganisms such as aspergillus |
US20150352078A1 (en) * | 2013-01-28 | 2015-12-10 | Pola Pharma Inc. | Pharmaceutical composition for diseases caused by pathogenic microorganisms such as candida |
JP5589110B1 (en) | 2013-03-08 | 2014-09-10 | 株式会社ポーラファルマ | Crystal having crystal habit and pharmaceutical composition containing the crystal as an active ingredient |
JP5680161B1 (en) * | 2013-09-06 | 2015-03-04 | 株式会社ポーラファルマ | Crystal having crystal habit and pharmaceutical composition containing the crystal as an active ingredient |
JP5587488B1 (en) | 2013-12-12 | 2014-09-10 | 株式会社ポーラファルマ | Evaluation method and index substance of preparation containing luliconazole |
AR100180A1 (en) * | 2014-04-25 | 2016-09-14 | Syngenta Participations Ag | IMIDAZOL MICROBIOCIDES DERIVATIVES |
US10703744B2 (en) | 2014-12-12 | 2020-07-07 | Glenmark Life Sciences Limited | Process for preparation of luliconazole |
WO2017108972A1 (en) | 2015-12-21 | 2017-06-29 | Laboratorios Lesvi, S.L. | Compounds of r-(-)-(e)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1 -imidazolylacetonitrile-ha (luliconazole-ha) as antifungals |
CN106008166B (en) * | 2016-05-17 | 2018-09-25 | 上海福乐医药科技有限公司 | A kind of industrialized preparing process of chirality 2- chloro- 1- (2,4 dichloro benzene base) ethyl alcohol |
US11185548B2 (en) | 2016-12-23 | 2021-11-30 | Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases |
TR201714882A2 (en) | 2017-10-03 | 2019-04-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Topical pharmaceutical compositions of luliconazole |
US10898470B1 (en) | 2019-08-13 | 2021-01-26 | Sato Pharmaceutical Co., Ltd. | Pharmaceutical composition containing antifungal agent as active ingredient |
WO2023131969A1 (en) * | 2022-01-09 | 2023-07-13 | Kimia Biosciences Limited | Improved process for the preparation of luliconazole |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE87920T1 (en) * | 1985-10-09 | 1993-04-15 | Nihon Nohyaku Co Ltd | KETEN-S,S,-ACETAL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND METHOD FOR CUREING MYCOSIS USING THESE DERIVATIVES. |
EP0218736B1 (en) * | 1985-10-10 | 1993-04-07 | Nihon Nohyaku Co., Ltd. | A ketene s,s-acetal derivative, a process for manufacturing thereof and a method for curing mycosis by administering it |
JP3030780B2 (en) * | 1988-12-29 | 2000-04-10 | 日本農薬株式会社 | Optically active ketene dithioacetal derivative and method for producing the same |
JPH0386337A (en) * | 1989-08-28 | 1991-04-11 | Maeda Seisakusho:Kk | Multiple seaming matching provided with expanding chuck and method for multiple seaming |
CN1038247C (en) * | 1990-05-16 | 1998-05-06 | 云南省建筑材料科学研究设计院 | New phospho-gypsum cementing agent, and production and application thereof |
JP3038519B2 (en) * | 1992-01-28 | 2000-05-08 | 日本農薬株式会社 | Wound healing promoter |
-
1996
- 1996-07-05 ES ES009750013A patent/ES2137888B1/en not_active Expired - Fee Related
- 1996-07-05 DE DE19681478T patent/DE19681478B4/en not_active Expired - Lifetime
- 1996-07-05 ZA ZA965745A patent/ZA965745B/en unknown
- 1996-07-05 KR KR10-1998-0700071A patent/KR100386491B1/en not_active IP Right Cessation
- 1996-07-05 NZ NZ311796A patent/NZ311796A/en not_active IP Right Cessation
- 1996-07-05 WO PCT/JP1996/001872 patent/WO1997002821A2/en active IP Right Grant
- 1996-07-05 EP EP96922243A patent/EP0839035B1/en not_active Expired - Lifetime
- 1996-07-05 US US08/981,420 patent/US5900488A/en not_active Expired - Lifetime
- 1996-07-05 CH CH00023/98A patent/CH692045A5/en not_active IP Right Cessation
- 1996-07-05 AT AT0906196A patent/AT407832B/en not_active IP Right Cessation
- 1996-07-05 GB GB9726766A patent/GB2317615B/en not_active Expired - Lifetime
- 1996-07-05 IL IL12261896A patent/IL122618A/en not_active IP Right Cessation
- 1996-07-05 CA CA002226214A patent/CA2226214C/en not_active Expired - Lifetime
- 1996-07-05 IN IN1499DE1996 patent/IN185384B/en unknown
- 1996-07-05 CN CN96196659A patent/CN1091596C/en not_active Expired - Lifetime
- 1996-07-06 TW TW085108169A patent/TW450969B/en not_active IP Right Cessation
-
1997
- 1997-12-31 LU LU90190A patent/LU90190B1/en active
-
1998
- 1998-01-06 NO NO980055A patent/NO980055L/en not_active Application Discontinuation
- 1998-01-07 FI FI980023A patent/FI119357B/en not_active IP Right Cessation
- 1998-01-07 DK DK199800013A patent/DK176599B1/en not_active IP Right Cessation
- 1998-01-07 SE SE9800016A patent/SE9800016D0/en not_active Application Discontinuation
- 1998-09-18 HK HK98110741A patent/HK1009751A1/en not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2137888B1 (en) | ANTIFUNGIC AGENT, COMPOSED FOR THE SAME PROCEDURE FOR ITS PRODUCTION AND METHOD FOR USE. | |
EP0665590A3 (en) | Microstructure, process for manufacturing thereof and devices incorporating the same. | |
HUP0002729A3 (en) | 4-haloalkyl-3-heterocyclylpyridines and 4-haloalkyl-5-heterocyclylpyridines, method for the production thereof, agents containing the same and their use as pesticides | |
BR0015985B1 (en) | Apply and aircraft. | |
DE69410470T2 (en) | MODIFIED CONJUGATED DIENCOPOLYMER, METHOD FOR THE PRODUCTION THEREOF AND THE COMPOSITION THEREOF | |
BR9916481B1 (en) | composite material and method to do the same. | |
MX9205032A (en) | 1,2-DIHYDRO-2-OXO-PIRIDINES AND PROCEDURE FOR ITS PREPARATION. | |
PT101537A (en) | LINK SET FOR CURTAINS AND LINK FOR CURTAINS. | |
NO962275D0 (en) | Spike-free tire, vulcanization form and tire made using the same | |
AU5855498A (en) | Monoolefinic c5-mononitriles, method for the production and the use thereof | |
MX9203903A (en) | FIBRID THICKENERS AND THE PROCESS FOR THEIR MANUFACTURE. | |
TR199600028A2 (en) | 2,9-disubstituted purin-6-them. | |
DE59300631D1 (en) | Biodegradable, aqueous dispersions. | |
TR199801871A3 (en) | Biphenylsulfonylcyanamides production method and their use as drugs. | |
NL1013684A1 (en) | Photoresist layer crosslinker, and photoresist composition comprising the same. | |
TR28858A (en) | The method for producing N'-substituted-N, N'-diacilhydrazines with insecticide properties. | |
ID29249A (en) | 1,3-DIARIL-2-PIRID-2-IL-3- (PIRID-2-ILAMINO) SUBSTITUTED PROPANOLS, THEIR METHODS FOR PRODUCING, THE USE OF THE PHARMACY, AND THE USE OF ITS. | |
BR9802621B1 (en) | Method for the production of a prepreg and use of a prepreg. | |
TR27902A (en) | Trifendioxazine compounds, the method for their production and their use as dyestuff. | |
ITGE930084A0 (en) | SAFE, PARTICULARLY FOR UNDER GUNS OR SIMILAR. | |
TR199501276A2 (en) | Substituted cycloalkylamino-and-alkoxy-heterocycyls are used as methods and pest control agents for their production. | |
BR9800928B1 (en) | cosmetic material and process for preparing the same. | |
TR27897A (en) | The method for producing ethanol and isopropanol. | |
BR9711039B1 (en) | catalytic resin curing agent and method for doing the same. | |
NO951626D0 (en) | Apparatus for supplying foaming agent and the like. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19991216 Kind code of ref document: A1 Effective date: 19991216 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20161026 |