ES2133143T3 - Composicion de tincion biologica, procedimiento de preparacion y procedimiento de utilizacion para la deteccion del cancer epitelial. - Google Patents
Composicion de tincion biologica, procedimiento de preparacion y procedimiento de utilizacion para la deteccion del cancer epitelial.Info
- Publication number
- ES2133143T3 ES2133143T3 ES92921881T ES92921881T ES2133143T3 ES 2133143 T3 ES2133143 T3 ES 2133143T3 ES 92921881 T ES92921881 T ES 92921881T ES 92921881 T ES92921881 T ES 92921881T ES 2133143 T3 ES2133143 T3 ES 2133143T3
- Authority
- ES
- Spain
- Prior art keywords
- composition
- procedure
- detection
- epithelial cancer
- toluidine blue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title 2
- 201000009030 Carcinoma Diseases 0.000 title 1
- 239000003535 biological staining Substances 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 abstract 3
- 239000007800 oxidant agent Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Optics & Photonics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cosmetics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Transceivers (AREA)
- Mobile Radio Communication Systems (AREA)
Abstract
UNA COMPOSICION COLORANTE BIOLOGICA, QUE CONTIENE O AZUL TOLUIDINA Y UN AGENTE OXIDANTE FARMACEUTICAMENTE ACEPTABLE, PARA CONVERTIR CUALQUIER O AZUL LEUCO ROMATICA. UNA COMPOSICION SECA PARA PREPARAR EL COLORANTE INCLUYE: EL O AZUL TOLUIDINA, EL AGENTE OXIDANTE Y UN AGENTE EFERVESCENTE. ESTAS COMPOSICIONES ESTAN INDICADAS PREFERENTEMENTE PARA MEJORAR LA ESTABILIDAD Y CONSISTENCIA CLINICA. LA COMPOSICIONES PARA TRATAMIENTOS POR VIA ORAL CONTIENEN ADEMAS UN COMPONENTE AROMATICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78552091A | 1991-10-31 | 1991-10-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2133143T3 true ES2133143T3 (es) | 1999-09-01 |
Family
ID=25135780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92921881T Expired - Lifetime ES2133143T3 (es) | 1991-10-31 | 1992-10-07 | Composicion de tincion biologica, procedimiento de preparacion y procedimiento de utilizacion para la deteccion del cancer epitelial. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5372801A (es) |
EP (1) | EP0565668B1 (es) |
JP (1) | JP3549880B2 (es) |
KR (1) | KR100242727B1 (es) |
AT (1) | ATE181510T1 (es) |
AU (1) | AU661727B2 (es) |
CA (1) | CA2097695C (es) |
DE (1) | DE69229471T2 (es) |
DK (1) | DK0565668T3 (es) |
ES (1) | ES2133143T3 (es) |
GR (1) | GR3031233T3 (es) |
WO (1) | WO1993008847A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6417003B1 (en) * | 1993-01-14 | 2002-07-09 | Zila, Inc. | Method and kit for epithelial cancer screening |
FI97630C (fi) * | 1995-02-23 | 1997-01-27 | Carefibres Oy | Kuitumateriaali ja menetelmä sen valmistamiseksi |
US5605812A (en) * | 1995-05-19 | 1997-02-25 | Charm Sciences, Inc. | Test kit and method for the quantitative determination of coliform bacteria and E. coli |
ATE198222T1 (de) * | 1995-10-05 | 2001-01-15 | Blz Gmbh | Verfahren zur herstellung eines schneidwerkzeuges |
ES2208727T3 (es) * | 1996-01-16 | 2004-06-16 | Zila, Inc. | Procedimientos y composiciones para la deteccion in vivo de canceres y estados precancerosos de la cavidad bucal. |
JPH11504557A (ja) * | 1996-02-29 | 1999-04-27 | ジラ・ファーマスーティカルス・インコーポレーテッド | 上皮癌選別の為の方法及び事前包装スワブ棒 |
US6083487A (en) * | 1997-08-25 | 2000-07-04 | Advanced Photodynamic Technologies, Inc. | Methylene blue and toluidene blue mediated fluorescence diagnosis of cancer |
AU5357498A (en) * | 1997-11-13 | 1999-06-07 | Zila, Inc. | (in vivo) stain composition, process of manufacture, and methods of use to identify dysplastic tissue |
US6086852A (en) * | 1997-11-13 | 2000-07-11 | Zila, Inc. | In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue |
CA2250731C (en) | 1997-11-13 | 2006-03-14 | Douglas D. Burkett | In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue |
US6194573B1 (en) * | 1997-11-13 | 2001-02-27 | Zila, Inc. | Process for manufacture of in vivo stain composition |
KR100641972B1 (ko) * | 2000-01-31 | 2006-11-02 | 자일러 바이오테크놀로지, 인크. | 생체내 염료 화합물 및 이형성 조직을 확인하는데사용하는 방법 |
WO2001064110A1 (en) * | 2000-02-28 | 2001-09-07 | Zila, Inc. | Method for detecting and killing epithelial cancer cells |
US6649144B1 (en) * | 2000-02-28 | 2003-11-18 | Zila, Inc. | Method for detecting and killing epithelial cancer cells |
WO2002003048A1 (en) * | 2000-06-30 | 2002-01-10 | Zila, Inc. | Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer |
AU784558B2 (en) * | 2000-06-30 | 2006-05-04 | Zila Biotechnology, Inc. | Rhodamine diagnostic agent and diagnostic methods for detections of epithelial cancer |
IL148429A0 (en) * | 2000-07-20 | 2002-09-12 | Zila Inc | Improved diagnostic method for detecting dysplastic epithelial tissue |
US20040146919A1 (en) * | 2002-05-18 | 2004-07-29 | Burkett Douglas D. | Method for early prediction of the onset of invasive cancer |
BR0015706A (pt) * | 2000-09-26 | 2002-07-16 | Zila Inc | Processo prognóstico para a previsão precoce do eventual desenvolvimento de cãncer invasivo |
EP1463833A4 (en) * | 2001-12-14 | 2006-06-07 | Zila Inc | MOLECULAR ANALYSIS DIRECTED BY LIGHT FOR THE PROGNOSIS AND DIAGNOSIS OF CANCER |
US20030017158A1 (en) * | 2002-03-08 | 2003-01-23 | Bernal Samuel D. | Method for detecting and killing epithelial cancer cells |
US20060110326A1 (en) * | 2002-06-04 | 2006-05-25 | Zila, Inc. | Toluidine blue o drug substance and use thereof for in vitro staining and chemotherapeutic treatment of dysplastic tissues |
JP2005535605A (ja) * | 2002-06-04 | 2005-11-24 | ジラ バイオテクノロジー・インク | トルイジンブルーo薬剤および形成異常組織のインビボ染色と化学療法処置におけるその用途 |
US7910531B2 (en) | 2004-06-17 | 2011-03-22 | C2C Technologies Llc | Composition and method for producing colored bubbles |
AT501919B1 (de) * | 2005-06-14 | 2008-09-15 | Erber Ag | Probiotischer, gesundheits- bzw. leistungsfördernder futtermittel- und/oder trinkwasserzusatz für tiere sowie seine verwendung |
US20080299182A1 (en) * | 2007-03-01 | 2008-12-04 | Shuyuan Zhang | Methods and formulations for topical gene therapy |
US20090023138A1 (en) * | 2007-07-17 | 2009-01-22 | Zila Biotechnology, Inc. | Oral cancer markers and their detection |
IT1398643B1 (it) * | 2010-03-04 | 2013-03-08 | Cosmo Technologies Ltd | Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa |
CN102221526A (zh) * | 2011-03-09 | 2011-10-19 | 叶欣 | 用于筛选口腔内膜细胞早期病变的组合试剂及其使用方法 |
PT106082A (pt) * | 2012-01-04 | 2013-07-04 | Fernando Jorge Neves Ferreira | Composição fixadora para citologia, método de fixação de células e suas aplicações |
RU2700680C1 (ru) * | 2019-03-14 | 2019-09-18 | Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) | Способ хирургического лечения меланомы кожи |
IT202100018434A1 (it) * | 2021-07-13 | 2023-01-13 | Diapath S P A | Composizioni coloranti per campioni biologici, citologici, istologici e autoptici. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2571593A (en) * | 1950-10-16 | 1951-10-16 | Abbott Lab | Preparation of stable leuco toluidine blue o solutions |
US3743088A (en) * | 1971-01-18 | 1973-07-03 | R Henkin | Diagnostic device and method of treatment |
US4181128A (en) * | 1975-11-28 | 1980-01-01 | Massachusetts Institute Of Technology | Virus inactivation applicator and the like |
US4321251A (en) * | 1979-12-19 | 1982-03-23 | The United States Of America As Represented By The Department Of Health And Human Services | Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse |
US4977177A (en) * | 1985-04-30 | 1990-12-11 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents |
JP2681053B2 (ja) * | 1989-02-27 | 1997-11-19 | 三井サイテック株式会社 | 紙の製造法 |
US5018531A (en) * | 1989-09-07 | 1991-05-28 | Hartman William B | Skin blemish measuring and recording system and method |
-
1992
- 1992-10-07 DK DK92921881T patent/DK0565668T3/da active
- 1992-10-07 EP EP92921881A patent/EP0565668B1/en not_active Expired - Lifetime
- 1992-10-07 CA CA002097695A patent/CA2097695C/en not_active Expired - Fee Related
- 1992-10-07 ES ES92921881T patent/ES2133143T3/es not_active Expired - Lifetime
- 1992-10-07 JP JP50843093A patent/JP3549880B2/ja not_active Expired - Fee Related
- 1992-10-07 AT AT92921881T patent/ATE181510T1/de not_active IP Right Cessation
- 1992-10-07 WO PCT/US1992/008722 patent/WO1993008847A1/en active IP Right Grant
- 1992-10-07 KR KR1019930701988A patent/KR100242727B1/ko not_active IP Right Cessation
- 1992-10-07 DE DE69229471T patent/DE69229471T2/de not_active Expired - Fee Related
- 1992-10-07 AU AU27788/92A patent/AU661727B2/en not_active Ceased
-
1993
- 1993-06-07 US US08/067,506 patent/US5372801A/en not_active Expired - Lifetime
-
1999
- 1999-09-16 GR GR990402324T patent/GR3031233T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2097695A1 (en) | 1993-05-01 |
DK0565668T3 (da) | 2000-01-31 |
WO1993008847A1 (en) | 1993-05-13 |
EP0565668A1 (en) | 1993-10-20 |
ATE181510T1 (de) | 1999-07-15 |
EP0565668B1 (en) | 1999-06-23 |
DE69229471D1 (de) | 1999-07-29 |
AU661727B2 (en) | 1995-08-03 |
EP0565668A4 (en) | 1994-09-07 |
JP3549880B2 (ja) | 2004-08-04 |
KR100242727B1 (ko) | 2000-03-02 |
KR930703022A (ko) | 1993-11-29 |
DE69229471T2 (de) | 1999-11-25 |
AU2778892A (en) | 1993-06-07 |
JPH06507419A (ja) | 1994-08-25 |
GR3031233T3 (en) | 1999-12-31 |
US5372801A (en) | 1994-12-13 |
CA2097695C (en) | 2000-08-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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