ES2129349A1 - Procedimiento para preparar granisetron. - Google Patents

Procedimiento para preparar granisetron.

Info

Publication number
ES2129349A1
ES2129349A1 ES09700270A ES9700270A ES2129349A1 ES 2129349 A1 ES2129349 A1 ES 2129349A1 ES 09700270 A ES09700270 A ES 09700270A ES 9700270 A ES9700270 A ES 9700270A ES 2129349 A1 ES2129349 A1 ES 2129349A1
Authority
ES
Spain
Prior art keywords
granisetron
preparation
salt
same
isocyanate group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09700270A
Other languages
English (en)
Other versions
ES2129349B1 (es
Inventor
Laurence C Powling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of ES2129349A1 publication Critical patent/ES2129349A1/es
Application granted granted Critical
Publication of ES2129349B1 publication Critical patent/ES2129349B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para preparar granisetrón haciendo reacciona ácido 1-metilindazol-3-carboxílico o una sal del mismo con un compuesto de la Estructura (3) o una sal del mismo, en la que X representa un grupo de isocianato -NCO, o un grupo que es capaz de generar un grupo de isocianato al calentar, y opcionalmente formar una sal farmacéuticamente aceptable.
ES9700270A 1996-02-13 1997-02-11 Procedimiento para preparar granisetron. Expired - Fee Related ES2129349B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9602862.6A GB9602862D0 (en) 1996-02-13 1996-02-13 Novel process

Publications (2)

Publication Number Publication Date
ES2129349A1 true ES2129349A1 (es) 1999-06-01
ES2129349B1 ES2129349B1 (es) 2000-01-01

Family

ID=10788574

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9700270A Expired - Fee Related ES2129349B1 (es) 1996-02-13 1997-02-11 Procedimiento para preparar granisetron.

Country Status (2)

Country Link
ES (1) ES2129349B1 (es)
GB (1) GB9602862D0 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080606A1 (en) * 2002-03-26 2003-10-02 Laboratorios Vita, S.A. Process for preparing a pharmaceutically active compound (granisetron)
WO2008151677A1 (en) 2007-06-13 2008-12-18 Inke, S.A. Polymorphic form of granisetron base, methods for obtaining it and formulation containing it

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0200444A2 (en) * 1985-04-27 1986-11-05 Beecham Group Plc Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity
EP0214772A1 (en) * 1985-08-16 1987-03-18 Beecham Group Plc Novel compounds
EP0223385A2 (en) * 1985-10-21 1987-05-27 Beecham Group Plc 8-Azabicyclo[3,2,1]octane and 9-azabicyclo[3,3,1]nonane derivatives
WO1995023799A1 (en) * 1994-03-03 1995-09-08 Smithkline Beecham Plc Process for the preparation of an indazole-3-carboxamide derivative

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0200444A2 (en) * 1985-04-27 1986-11-05 Beecham Group Plc Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity
EP0214772A1 (en) * 1985-08-16 1987-03-18 Beecham Group Plc Novel compounds
EP0223385A2 (en) * 1985-10-21 1987-05-27 Beecham Group Plc 8-Azabicyclo[3,2,1]octane and 9-azabicyclo[3,3,1]nonane derivatives
WO1995023799A1 (en) * 1994-03-03 1995-09-08 Smithkline Beecham Plc Process for the preparation of an indazole-3-carboxamide derivative

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080606A1 (en) * 2002-03-26 2003-10-02 Laboratorios Vita, S.A. Process for preparing a pharmaceutically active compound (granisetron)
ES2197001A1 (es) * 2002-03-26 2003-12-16 Vita Lab Procedimiento de obtencion de un compuesto farmacuticamente activo.
US7071209B2 (en) 2002-03-26 2006-07-04 Laboratorios Vita, S.A. Process for preparing a pharmaceutically active compound (granisetron)
WO2008151677A1 (en) 2007-06-13 2008-12-18 Inke, S.A. Polymorphic form of granisetron base, methods for obtaining it and formulation containing it
US8304426B2 (en) 2007-06-13 2012-11-06 Inke, S.A. Polymorphic form of Granisetron base, methods for obtaining it and formulation containing it

Also Published As

Publication number Publication date
GB9602862D0 (en) 1996-04-10
ES2129349B1 (es) 2000-01-01

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