ES2127692A1 - Formulation of enrofloxacin in liposomes and preparation thereof - Google Patents
Formulation of enrofloxacin in liposomes and preparation thereofInfo
- Publication number
- ES2127692A1 ES2127692A1 ES09602400A ES9602400A ES2127692A1 ES 2127692 A1 ES2127692 A1 ES 2127692A1 ES 09602400 A ES09602400 A ES 09602400A ES 9602400 A ES9602400 A ES 9602400A ES 2127692 A1 ES2127692 A1 ES 2127692A1
- Authority
- ES
- Spain
- Prior art keywords
- enrofloxacin
- formulation
- liposomes
- preparation
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The formulation contains 40-75% of enrofloxacin, of which up to 55% is encapsulated inside the liposomes, with the remainder being in the external liquid phase. The formulation also contains a phospholipids concentration of 40 g/l relative to the final product, and can in addition include a fat-soluble antioxidant. The enrofloxacin liposomes are prepared by adding a solution of enrofloxacin and a polysaccharide in acetate buffer to a solution of phospholipids, at 70 degree C, followed by homogenization by microfluidization and final de-aeration. The enrofloxacin formulation can be used in veterinary medicine as an antibiotic against a large number of microorganisms and mycoplasmas.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9602400A ES2127692B1 (en) | 1996-11-14 | 1996-11-14 | FORMULATION OF ENROFLOXACIN IN LIPOSOMES AND ITS PREPARATION. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9602400A ES2127692B1 (en) | 1996-11-14 | 1996-11-14 | FORMULATION OF ENROFLOXACIN IN LIPOSOMES AND ITS PREPARATION. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2127692A1 true ES2127692A1 (en) | 1999-04-16 |
ES2127692B1 ES2127692B1 (en) | 2000-04-01 |
Family
ID=8296676
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9602400A Expired - Lifetime ES2127692B1 (en) | 1996-11-14 | 1996-11-14 | FORMULATION OF ENROFLOXACIN IN LIPOSOMES AND ITS PREPARATION. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2127692B1 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4923699A (en) * | 1988-06-03 | 1990-05-08 | Kaufman Herbert E | Eye treatment suspension |
WO1991009616A1 (en) * | 1989-12-22 | 1991-07-11 | Yale University | Quinolone antibiotics encapsulated in lipid vesicles |
CA2174803A1 (en) * | 1996-04-23 | 1997-10-24 | Jonathan P. Wong | Use of Liposome Encapsulated Ciprofloxacin as an Immunotherapeutic Drug |
-
1996
- 1996-11-14 ES ES9602400A patent/ES2127692B1/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4923699A (en) * | 1988-06-03 | 1990-05-08 | Kaufman Herbert E | Eye treatment suspension |
WO1991009616A1 (en) * | 1989-12-22 | 1991-07-11 | Yale University | Quinolone antibiotics encapsulated in lipid vesicles |
CA2174803A1 (en) * | 1996-04-23 | 1997-10-24 | Jonathan P. Wong | Use of Liposome Encapsulated Ciprofloxacin as an Immunotherapeutic Drug |
Non-Patent Citations (2)
Title |
---|
BASE DE DATOS WPI en EPOQUE & CA 2174803 A1 (CANADA MIN. NAT. DEFENCE) 24.10.1997 * |
M.T. MONTERO et al. Encapsulation of a quinolone in liposomes. Location and effect on lipid bilayers. J. MICROENCAPSULATION, 1994, Vol. 11, no 4, paginas 423-430. * |
Also Published As
Publication number | Publication date |
---|---|
ES2127692B1 (en) | 2000-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990416 Kind code of ref document: A1 Effective date: 19990416 |