ES2127692A1 - Formulation of enrofloxacin in liposomes and preparation thereof - Google Patents

Formulation of enrofloxacin in liposomes and preparation thereof

Info

Publication number
ES2127692A1
ES2127692A1 ES09602400A ES9602400A ES2127692A1 ES 2127692 A1 ES2127692 A1 ES 2127692A1 ES 09602400 A ES09602400 A ES 09602400A ES 9602400 A ES9602400 A ES 9602400A ES 2127692 A1 ES2127692 A1 ES 2127692A1
Authority
ES
Spain
Prior art keywords
enrofloxacin
formulation
liposomes
preparation
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09602400A
Other languages
Spanish (es)
Other versions
ES2127692B1 (en
Inventor
Xamani Manuel Sabes
Roura Pilar Rubert
I Coromina Josep Ferres
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Hipra SA
Original Assignee
Laboratorios Hipra SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Hipra SA filed Critical Laboratorios Hipra SA
Priority to ES9602400A priority Critical patent/ES2127692B1/en
Publication of ES2127692A1 publication Critical patent/ES2127692A1/en
Application granted granted Critical
Publication of ES2127692B1 publication Critical patent/ES2127692B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

The formulation contains 40-75% of enrofloxacin, of which up to 55% is encapsulated inside the liposomes, with the remainder being in the external liquid phase. The formulation also contains a phospholipids concentration of 40 g/l relative to the final product, and can in addition include a fat-soluble antioxidant. The enrofloxacin liposomes are prepared by adding a solution of enrofloxacin and a polysaccharide in acetate buffer to a solution of phospholipids, at 70 degree C, followed by homogenization by microfluidization and final de-aeration. The enrofloxacin formulation can be used in veterinary medicine as an antibiotic against a large number of microorganisms and mycoplasmas.
ES9602400A 1996-11-14 1996-11-14 FORMULATION OF ENROFLOXACIN IN LIPOSOMES AND ITS PREPARATION. Expired - Lifetime ES2127692B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9602400A ES2127692B1 (en) 1996-11-14 1996-11-14 FORMULATION OF ENROFLOXACIN IN LIPOSOMES AND ITS PREPARATION.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9602400A ES2127692B1 (en) 1996-11-14 1996-11-14 FORMULATION OF ENROFLOXACIN IN LIPOSOMES AND ITS PREPARATION.

Publications (2)

Publication Number Publication Date
ES2127692A1 true ES2127692A1 (en) 1999-04-16
ES2127692B1 ES2127692B1 (en) 2000-04-01

Family

ID=8296676

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9602400A Expired - Lifetime ES2127692B1 (en) 1996-11-14 1996-11-14 FORMULATION OF ENROFLOXACIN IN LIPOSOMES AND ITS PREPARATION.

Country Status (1)

Country Link
ES (1) ES2127692B1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension
WO1991009616A1 (en) * 1989-12-22 1991-07-11 Yale University Quinolone antibiotics encapsulated in lipid vesicles
CA2174803A1 (en) * 1996-04-23 1997-10-24 Jonathan P. Wong Use of Liposome Encapsulated Ciprofloxacin as an Immunotherapeutic Drug

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension
WO1991009616A1 (en) * 1989-12-22 1991-07-11 Yale University Quinolone antibiotics encapsulated in lipid vesicles
CA2174803A1 (en) * 1996-04-23 1997-10-24 Jonathan P. Wong Use of Liposome Encapsulated Ciprofloxacin as an Immunotherapeutic Drug

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BASE DE DATOS WPI en EPOQUE & CA 2174803 A1 (CANADA MIN. NAT. DEFENCE) 24.10.1997 *
M.T. MONTERO et al. Encapsulation of a quinolone in liposomes. Location and effect on lipid bilayers. J. MICROENCAPSULATION, 1994, Vol. 11, no 4, paginas 423-430. *

Also Published As

Publication number Publication date
ES2127692B1 (en) 2000-04-01

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