ES2124321T3 - Produccion de pdgf-ab heterodimero con la ayuda de un sistema de vector bicistronico en celulas de mamiferos. - Google Patents

Produccion de pdgf-ab heterodimero con la ayuda de un sistema de vector bicistronico en celulas de mamiferos.

Info

Publication number
ES2124321T3
ES2124321T3 ES93919177T ES93919177T ES2124321T3 ES 2124321 T3 ES2124321 T3 ES 2124321T3 ES 93919177 T ES93919177 T ES 93919177T ES 93919177 T ES93919177 T ES 93919177T ES 2124321 T3 ES2124321 T3 ES 2124321T3
Authority
ES
Spain
Prior art keywords
mammalian cells
vector system
heterodimero
pdgf
aid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93919177T
Other languages
English (en)
Inventor
Wolfram Eichner
Volker Achterberg
Albrecht Dorschner
Wolfgang Meyer-Ingold
Heiko Mielke
Wilhelm Dirks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Beiersdorf AG
Original Assignee
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmholtz Zentrum fuer Infektionsforschung HZI GmbH, Beiersdorf AG filed Critical Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Application granted granted Critical
Publication of ES2124321T3 publication Critical patent/ES2124321T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A LA ELABORACION RECOMBINANTE DE PDGFAB EN CELULAS DE MAMIFEROS POR MEDIO DE UN SISTEMA DE VECTOR BICISTRONICO EN DONDE SE LOCALIZA UNA SECUENCIA IRES ENTRE EL PRIMER Y SEGUNDO CISTRON Y DONDE EL GEN DE CODIFICACION DE CADENA B SE LOCALIZA EN EL PRIMER CISTRON. LA UNIDAD DE EXPRESION DESCRITA PERMITE LA EXPRESION EQUIMOLAR DE CADENAS POLIPEPTIDAS A Y B.
ES93919177T 1992-08-27 1993-08-26 Produccion de pdgf-ab heterodimero con la ayuda de un sistema de vector bicistronico en celulas de mamiferos. Expired - Lifetime ES2124321T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4228457A DE4228457A1 (de) 1992-08-27 1992-08-27 Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen

Publications (1)

Publication Number Publication Date
ES2124321T3 true ES2124321T3 (es) 1999-02-01

Family

ID=6466527

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93919177T Expired - Lifetime ES2124321T3 (es) 1992-08-27 1993-08-26 Produccion de pdgf-ab heterodimero con la ayuda de un sistema de vector bicistronico en celulas de mamiferos.

Country Status (8)

Country Link
US (2) US5665567A (es)
EP (1) EP0658199B1 (es)
JP (1) JP3515111B2 (es)
AU (1) AU4953893A (es)
DE (2) DE4228457A1 (es)
DK (1) DK0658199T3 (es)
ES (1) ES2124321T3 (es)
WO (1) WO1994005786A1 (es)

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DK0658199T3 (da) 1999-06-28
DE4228457A1 (de) 1994-04-28
EP0658199B1 (de) 1998-10-21
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AU4953893A (en) 1994-03-29
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