ES2123546T3 - Uso de derivados de 1-(aminoalquil)-3-quinoxalina-2-ona para la preparacion de composiciones neuroprotectoras. - Google Patents
Uso de derivados de 1-(aminoalquil)-3-quinoxalina-2-ona para la preparacion de composiciones neuroprotectoras.Info
- Publication number
- ES2123546T3 ES2123546T3 ES92810863T ES92810863T ES2123546T3 ES 2123546 T3 ES2123546 T3 ES 2123546T3 ES 92810863 T ES92810863 T ES 92810863T ES 92810863 T ES92810863 T ES 92810863T ES 2123546 T3 ES2123546 T3 ES 2123546T3
- Authority
- ES
- Spain
- Prior art keywords
- neuroprotectoral
- preparation
- compositions
- quinoxaline
- aminoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- ORKBYCQJWQBPFG-WOMZHKBXSA-N (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 ORKBYCQJWQBPFG-WOMZHKBXSA-N 0.000 abstract 1
- -1 BUTYL Chemical group 0.000 abstract 1
- 241000999918 Portia Species 0.000 abstract 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical group [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical group C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
USO DE COMPUESTOS DE LA FORMULA DONDE R1 Y R2 SON CADA UNO INDEPENDIENTEMENTE HIDROGENO, METILO, ETILO, PROPILO, BUTILO O R1 Y R2 SON CONJUNTAMENTE CICLOALQUILO; R3 ES METOXI, ETOXI, HIDROXI, HIDROGENO, ALQUILO C1 ALQUIER SAL FARMACEUTICAMENTE ACEPTABLE CONSIGUIENTE, PARA LA PREPARACION DE COMPOSICIONES FARMACEUTICAS NEUROPROTECTORAS, PARA LA PREVENCION O TRATAMIENTO DE NEUROTOXICIDAD POR MEDIACION DE RECEPTOR DE GLUTAMATO O INDUCIDA POR GLUTAMATO Y MOLESTIA FUNCIONALES DEL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91119501 | 1991-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2123546T3 true ES2123546T3 (es) | 1999-01-16 |
Family
ID=8207340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92810863T Expired - Lifetime ES2123546T3 (es) | 1991-11-15 | 1992-11-09 | Uso de derivados de 1-(aminoalquil)-3-quinoxalina-2-ona para la preparacion de composiciones neuroprotectoras. |
Country Status (5)
Country | Link |
---|---|
US (1) | US5563140A (es) |
JP (1) | JPH06239747A (es) |
AT (1) | ATE171374T1 (es) |
DE (1) | DE69227088T2 (es) |
ES (1) | ES2123546T3 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT784973E (pt) * | 1995-10-10 | 2002-06-28 | Pfizer | Derivados de quinoxalina para o tratamento de zumbido nos ouvidos |
WO1999007302A1 (en) * | 1997-08-07 | 1999-02-18 | Natan Bauman | Apparatus and method for an auditory stimulator |
AT408837B (de) * | 1998-06-19 | 2002-03-25 | Phafag Ag | Verwendung von caroverin und/oder caroverin. hydrochlorid zur herstellung von als antioxidantien wirkenden zusammensetzungen und/oder von neuroregenerativen zusammensetzungen |
US20030045541A1 (en) * | 2001-07-23 | 2003-03-06 | Christopher Bruckner | GABA-Receptor modulators with NMDA-Antagonistic activity |
WO2004012705A1 (en) * | 2002-07-31 | 2004-02-12 | Phafag Ag | A pharmaceutical formulation and its use in the treatment of inner ear diseases |
US7751580B2 (en) * | 2002-09-10 | 2010-07-06 | Auditory Licensing Company, Llc | Open ear hearing aid system |
US7421086B2 (en) | 2002-09-10 | 2008-09-02 | Vivatone Hearing Systems, Llc | Hearing aid system |
US20050078843A1 (en) * | 2003-02-05 | 2005-04-14 | Natan Bauman | Hearing aid system |
CA2594963A1 (en) * | 2005-01-24 | 2006-07-27 | Neurosystec Corporation | Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues |
WO2006096518A2 (en) * | 2005-03-04 | 2006-09-14 | Neurosystec Corporation | Improved gacyclidine formulations |
WO2007012064A2 (en) * | 2005-07-20 | 2007-01-25 | Cypress Bioscience, Inc. | Prevention and treatment of hearing disorders |
US8267905B2 (en) | 2006-05-01 | 2012-09-18 | Neurosystec Corporation | Apparatus and method for delivery of therapeutic and other types of agents |
US7803148B2 (en) * | 2006-06-09 | 2010-09-28 | Neurosystec Corporation | Flow-induced delivery from a drug mass |
JP2009544355A (ja) * | 2006-07-20 | 2009-12-17 | ニューロシステック コーポレイション | 眼科薬物送達のためのデバイス、システム、および方法 |
JP2010511595A (ja) * | 2006-07-31 | 2010-04-15 | ニューロシステック コーポレイション | 遊離塩基ガシクリジンナノ粒子 |
US20080065002A1 (en) * | 2006-09-07 | 2008-03-13 | Neurosystec Corporation | Catheter for Localized Drug Delivery and/or Electrical Stimulation |
KR101117129B1 (ko) | 2009-09-14 | 2012-02-24 | 한국화학연구원 | 신규한 퀴녹살린 유도체 및 이를 포함하는 줄기세포의 신경세포로의 분화유도용 조성물 |
EP2522350B1 (de) | 2011-05-12 | 2013-07-31 | Immunopharm AG | Verwendung der Wirkstoffkombination aus einem 1-Diethylaminoethyl-3-Chinoxalin-2-on Derivat und einem Oxysterol zur Durchbrechung von Resistenzen bei der Behandlung von Krebs und zur Erhöhung der Immunleistungsfähigkeit bei Krebs, bakteriellen und viralen Erkrankungen, Autoimmunerkrankungen, erhöhter Stress- und Umweltbelastung |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE228204C (es) * | ||||
EP0032564A1 (de) * | 1979-12-28 | 1981-07-29 | Medichemie Ag | Pharmazeutische Verwendung von Caroverin und/oder Caroverinsalzen sowie Caroverinsalze mit Xanthinderivat-Säureresten und Nicotinsäurerest |
US4975430A (en) * | 1989-06-16 | 1990-12-04 | The State Of Oregon Acting By And Through The State Board Of Education On Behalf Of The Oregon Health Sciences University | CNQX and its analogs as therapeutics for degenerative neural diseases |
US5037848A (en) * | 1989-08-25 | 1991-08-06 | Washington University | Aryl-cycloalkyl-alkanolamines for treatment of epilepsy |
-
1992
- 1992-11-09 AT AT92810863T patent/ATE171374T1/de not_active IP Right Cessation
- 1992-11-09 ES ES92810863T patent/ES2123546T3/es not_active Expired - Lifetime
- 1992-11-09 DE DE69227088T patent/DE69227088T2/de not_active Expired - Fee Related
- 1992-11-16 US US07/975,328 patent/US5563140A/en not_active Expired - Lifetime
- 1992-11-16 JP JP4329024A patent/JPH06239747A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH06239747A (ja) | 1994-08-30 |
ATE171374T1 (de) | 1998-10-15 |
US5563140A (en) | 1996-10-08 |
DE69227088T2 (de) | 1999-06-02 |
DE69227088D1 (de) | 1998-10-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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