ES2117132T3 - Sales de desferrioxamina-b y su uso como queladores de hierro eficaces por via oral. - Google Patents

Sales de desferrioxamina-b y su uso como queladores de hierro eficaces por via oral.

Info

Publication number
ES2117132T3
ES2117132T3 ES93911928T ES93911928T ES2117132T3 ES 2117132 T3 ES2117132 T3 ES 2117132T3 ES 93911928 T ES93911928 T ES 93911928T ES 93911928 T ES93911928 T ES 93911928T ES 2117132 T3 ES2117132 T3 ES 2117132T3
Authority
ES
Spain
Prior art keywords
chelelers
desferrioxamine
salts
effective iron
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93911928T
Other languages
English (en)
Inventor
Nicholas Lowther
Ian Francis Hassan
Ian Timothy William Matthews
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2117132T3 publication Critical patent/ES2117132T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UNA SAL DE LA FORMULA (I) EN DONDE X REPRESENTA UN GRUPO DE LA FORMULA (II), Y REPRESENTA UN GRUPO DE LA FORMULA (III) Y R REPRESENTA EL RESIDUO DE UN ACIDO SULFONICO ALIFATICO O CICLOALIFATICO QUE TIENE AL MENOS TRES ATOMOS DE CARBONO DESPUES DE LA ELIMINACION DEL MISMO DE UN GRUPO - SO3H.
ES93911928T 1992-06-03 1993-05-06 Sales de desferrioxamina-b y su uso como queladores de hierro eficaces por via oral. Expired - Lifetime ES2117132T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929211779A GB9211779D0 (en) 1992-06-03 1992-06-03 Amine salts

Publications (1)

Publication Number Publication Date
ES2117132T3 true ES2117132T3 (es) 1998-08-01

Family

ID=10716488

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93911928T Expired - Lifetime ES2117132T3 (es) 1992-06-03 1993-05-06 Sales de desferrioxamina-b y su uso como queladores de hierro eficaces por via oral.

Country Status (17)

Country Link
US (2) US5739167A (es)
EP (1) EP0643690B1 (es)
JP (1) JPH07507288A (es)
KR (1) KR950701907A (es)
AT (1) ATE166342T1 (es)
AU (1) AU672607B2 (es)
CA (1) CA2135394A1 (es)
DE (1) DE69318711T2 (es)
DK (1) DK0643690T3 (es)
ES (1) ES2117132T3 (es)
FI (1) FI945654A (es)
GB (1) GB9211779D0 (es)
HK (1) HK1009330A1 (es)
NO (1) NO302749B1 (es)
NZ (1) NZ252738A (es)
TW (1) TW230203B (es)
WO (1) WO1993024451A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR009655A1 (es) * 1996-12-10 2000-04-26 Novartis Ag Una composicion parenteralmente inyectable, un metodo para su preparacion, metodos para el tratamiento de enfermedades, una modificacion decristal de 1-decansulfonato de desferrioxamina, su uso, un proceso para la produccion de dicha modificacion de cristal y una preparacion farmaceutica que
US7045531B1 (en) 1997-03-11 2006-05-16 The General Hospital Corporation Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator
GB9727224D0 (en) * 1997-12-23 1998-02-25 Nycomed Imaging As Method
US6638711B1 (en) 1999-04-29 2003-10-28 The General Hospital Corporation Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation
US6323218B1 (en) 1998-03-11 2001-11-27 The General Hospital Corporation Agents for use in the treatment of Alzheimer's disease
GB0117645D0 (en) * 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
US6958161B2 (en) * 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
US8236783B2 (en) * 2006-08-15 2012-08-07 Duke University ROS-sensitive iron chelators and methods of using the same
US9139456B2 (en) 2008-04-16 2015-09-22 The Curators Of The University Of Missouri Chelating compounds and immobilized tethered chelators
US9259670B2 (en) 2008-04-16 2016-02-16 The University Of Kentucky Research Foundation Flow-through filter to remove aluminum from medical solutions
US7932326B2 (en) * 2008-04-16 2011-04-26 The University Of Kentucky Research Foundation Chelating compounds and immobilized tethered chelators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH438351A (de) * 1959-09-25 1967-06-30 Ciba Geigy Verfahren zur Herstellung neuer Wuchsstoffe
FR1898M (fr) * 1961-04-07 1963-07-08 Ciba Geigy Nouvelle substance utilisable en thérapeutique.
US3679660A (en) * 1969-06-09 1972-07-25 Agatha C Magnus Glucosamine-alkylsulfonate and process
US3652411A (en) * 1969-12-04 1972-03-28 Mobil Oil Corp Polyglycol base lubricant
US4419365A (en) * 1981-12-21 1983-12-06 Ciba-Geigy Corporation Method of treating Alzheimer's disease
US4684482A (en) * 1984-01-26 1987-08-04 Oral-D (L.P.) Orally effective ion chelators
IT1173992B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
MX12394A (es) * 1987-07-23 1993-12-01 Ciba Geigy Ag Procedimiento par la obtencion de carbamatos de polietilenglicol.
AU1996192A (en) * 1991-05-13 1992-12-30 Oral-D Substituted orally effective ion chelators related to deferoxamine

Also Published As

Publication number Publication date
US5663201A (en) 1997-09-02
CA2135394A1 (en) 1993-12-09
DE69318711D1 (de) 1998-06-25
NO944617L (no) 1995-01-05
EP0643690B1 (en) 1998-05-20
ATE166342T1 (de) 1998-06-15
GB9211779D0 (en) 1992-07-15
FI945654A0 (fi) 1994-11-30
DE69318711T2 (de) 1998-11-19
WO1993024451A1 (en) 1993-12-09
EP0643690A1 (en) 1995-03-22
TW230203B (es) 1994-09-11
KR950701907A (ko) 1995-05-17
AU672607B2 (en) 1996-10-10
JPH07507288A (ja) 1995-08-10
HK1009330A1 (en) 1999-05-28
NO302749B1 (no) 1998-04-20
AU4270093A (en) 1993-12-30
FI945654A (fi) 1994-11-30
US5739167A (en) 1998-04-14
NO944617D0 (no) 1994-12-01
NZ252738A (en) 1996-08-27
DK0643690T3 (da) 1999-01-25

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