ES2112151B1 - NEW HOMOQUIRAL COMPOUNDS FOR THE PREPARATION OF KETOCONAZOLE, THERONAZOLE AND RELATED ANTIFUNGICS, PROCEDURE FOR THEIR MANUFACTURE AND USE OF THEM. - Google Patents
NEW HOMOQUIRAL COMPOUNDS FOR THE PREPARATION OF KETOCONAZOLE, THERONAZOLE AND RELATED ANTIFUNGICS, PROCEDURE FOR THEIR MANUFACTURE AND USE OF THEM.Info
- Publication number
- ES2112151B1 ES2112151B1 ES9500553A ES9500553A ES2112151B1 ES 2112151 B1 ES2112151 B1 ES 2112151B1 ES 9500553 A ES9500553 A ES 9500553A ES 9500553 A ES9500553 A ES 9500553A ES 2112151 B1 ES2112151 B1 ES 2112151B1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- homoquiral
- preparation
- new
- theronazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
Abstract
NUEVOS COMPUESTOS HOMOQUIRALES PARA LA PREPARACION DE KETOCONAZOL, TERCONAZOL Y ANTIFUNGICOS RELACIONADOS, PROCEDIMIENTO PARA SU FABRICACION Y UTILIZACION DE LOS MISMOS. LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS HOMOQUIRALES QUE SON INTERMEDIOS EN LA PREPARACION DE DIVERSOS ANTIFUNGICOS AZOLICOS DE FORMULA V EN FORMA ENANTIOMERICAMENTE PURA, DONDE AR ES UN GRUPO FENILO O FENILO SUSTITUIDO, DE MODO QUE EL GRUPO FENILO SUSTITUIDO PUEDE CONTENER DE UNO A TRES SUSTITUYENTES, CADA UNO DE LOS CUALES INDEPENDIENTEMENTE PUEDE SER FLUOR, CLORO, BROMO, (C1-C4)-ALQUILO O (C1-C4)-ALQUILOXI; Y ES UNA AGRUPACION CH O UN ATOMO DE NITROGENO; Z ES UN GRUPO COCH3, CH(CH3)2 O DE IGUAL MODO LA PRESENTE INVENCION SE REFIERE A LOS PROPIOS COMPUESTOS (+)- TERCONAZOL Y (-)-TERCONAZOL. DICHOS COMPUESTOS PRESENTAN ACTIVIDAD ANTIFUNGICA Y ANTIBACTERIANA, PUDIENDO SER UTILIZADOS EN TERAPIA HUMANA Y EN VETERINARIA.NEW HOMOQUIRAL COMPOUNDS FOR THE PREPARATION OF KETOCONAZOLE, THERONAZOLE AND RELATED ANTIFUNGICS, PROCEDURE FOR THEIR MANUFACTURE AND USE OF THEM. THE PRESENT INVENTION REFERS TO NEW HOMOQUIRAL COMPOUNDS WHICH ARE INTERMEDIATE IN THE PREPARATION OF VARIOUS FORMULA V ANOLYOLIC ANTIFUNGALS, WHERE AR IS A FENILE, FENILE, AND SOUTHERN FUILLE GROUP. SUBSTITUTES, EACH OF WHICH MAY INDEPENDENTLY BE FLUORINE, CHLORINE, BROMINE, (C1-C4) -ALKYL OR (C1-C4) -ALKYLOXY; AND IT IS A GROUPING CH OR AN ATOM OF NITROGEN; Z IS A GROUP COCH3, CH (CH3) 2 OR IN THE SAME WAY THE PRESENT INVENTION REFERS TO THE OWN COMPOUNDS (+) - TERCONAZOL AND (-) - TERCONAZOL. SUCH COMPOUNDS PRESENT ANTIFUNGAL AND ANTIBACTERIAL ACTIVITY, MAY BE USED IN HUMAN AND VETERINARY THERAPY.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9500553A ES2112151B1 (en) | 1995-03-17 | 1995-03-17 | NEW HOMOQUIRAL COMPOUNDS FOR THE PREPARATION OF KETOCONAZOLE, THERONAZOLE AND RELATED ANTIFUNGICS, PROCEDURE FOR THEIR MANUFACTURE AND USE OF THEM. |
PCT/EP1996/000972 WO1996029325A1 (en) | 1995-03-17 | 1996-03-07 | Homochiral compounds for the preparation of ketoconazole, terconazole and related antifungal drugs |
AU50039/96A AU5003996A (en) | 1995-03-17 | 1996-03-07 | Homochiral compounds for the preparation of ketoconazole, terconazole and related antifungal drugs |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9500553A ES2112151B1 (en) | 1995-03-17 | 1995-03-17 | NEW HOMOQUIRAL COMPOUNDS FOR THE PREPARATION OF KETOCONAZOLE, THERONAZOLE AND RELATED ANTIFUNGICS, PROCEDURE FOR THEIR MANUFACTURE AND USE OF THEM. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2112151A1 ES2112151A1 (en) | 1998-03-16 |
ES2112151B1 true ES2112151B1 (en) | 1999-09-16 |
Family
ID=8289834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9500553A Expired - Lifetime ES2112151B1 (en) | 1995-03-17 | 1995-03-17 | NEW HOMOQUIRAL COMPOUNDS FOR THE PREPARATION OF KETOCONAZOLE, THERONAZOLE AND RELATED ANTIFUNGICS, PROCEDURE FOR THEIR MANUFACTURE AND USE OF THEM. |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU5003996A (en) |
ES (1) | ES2112151B1 (en) |
WO (1) | WO1996029325A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0938484A1 (en) * | 1996-11-12 | 1999-09-01 | Sepracor, Inc. | 2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole |
AU5251298A (en) * | 1996-11-12 | 1998-06-03 | Sepracor, Inc. | (2r,4s,s,r-) and (2s,4r,s,r-)hydroxyitraconazole |
AU5432698A (en) | 1996-11-12 | 1998-06-03 | Sepracor, Inc. | 2r,4s,s,s- and 2s,4r,s,s-hydroxyitraconazole |
CA2572223C (en) | 2004-06-25 | 2014-08-12 | The Johns Hopkins University | Angiogenesis inhibitors |
ATE474836T1 (en) * | 2007-05-25 | 2010-08-15 | Janssen Pharmaceutica Nv | IMPROVED SYNTHESIS OF (2S-CIS)-2-(BROMOMETHYL)- 2-(4-CHLORPHENYL)-1,3-DIOXOLANE-4-METHANOL-METHANESULFONATE(ESTER) |
EP2325178A4 (en) * | 2008-08-01 | 2011-10-05 | Daiso Co Ltd | Process for production of optically active compound |
EP3858357A1 (en) | 2020-01-28 | 2021-08-04 | Diaccurate | Use of azole compounds to stimulate the immune system and as inhibitors for s-pla2gib |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3039087A1 (en) * | 1980-10-16 | 1982-05-19 | Hoechst Ag, 6000 Frankfurt | 1- (1,3-DIOXOLAN-2-YLMETHYL) -AZOLES, THEIR SALTS, METHOD FOR THE PRODUCTION AND THEIR USE |
DE3166517D1 (en) * | 1980-11-24 | 1984-11-08 | Janssen Pharmaceutica Nv | NOVEL (2-ARYL-4-PHENYLTHIOALKYL-1,3-DIOXOLAN-2-YL-METHYL) AZOLE DERIVATIVES |
PT631578E (en) * | 1992-03-18 | 2001-11-30 | Janssen Pharmaceutica Nv | STEREOISOMERS OF ITRACONAZOLE AND SAPERCONAZOLE |
US5208331A (en) * | 1992-06-18 | 1993-05-04 | Syntex (U.S.A.) Inc. | Process for preparing 1,3-dioxolane derivatives |
US5403937A (en) * | 1993-04-30 | 1995-04-04 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
-
1995
- 1995-03-17 ES ES9500553A patent/ES2112151B1/en not_active Expired - Lifetime
-
1996
- 1996-03-07 AU AU50039/96A patent/AU5003996A/en not_active Abandoned
- 1996-03-07 WO PCT/EP1996/000972 patent/WO1996029325A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
ES2112151A1 (en) | 1998-03-16 |
WO1996029325A1 (en) | 1996-09-26 |
AU5003996A (en) | 1996-10-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19980316 Kind code of ref document: A1 Effective date: 19980316 |
|
FA2A | Application withdrawn |
Effective date: 20001102 |