ES2111493B1 - DERIVATIVES OF 1- (2- (SUBSTITUTED VINYL)) -5H-2,3-BENZO-DIAZEPINE, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND CORRESPONDING UTILIZATIONS. - Google Patents

DERIVATIVES OF 1- (2- (SUBSTITUTED VINYL)) -5H-2,3-BENZO-DIAZEPINE, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND CORRESPONDING UTILIZATIONS.

Info

Publication number
ES2111493B1
ES2111493B1 ES9600304A ES9600304A ES2111493B1 ES 2111493 B1 ES2111493 B1 ES 2111493B1 ES 9600304 A ES9600304 A ES 9600304A ES 9600304 A ES9600304 A ES 9600304A ES 2111493 B1 ES2111493 B1 ES 2111493B1
Authority
ES
Spain
Prior art keywords
alcoxi
group
derivatives
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9600304A
Other languages
Spanish (es)
Other versions
ES2111493A1 (en
Inventor
Pal Vago
Jozsef Reiter
Istvan Gyertvan
Istvan Gacsalyi
Andras Bilkei-Gorzo
Andras Egyed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to ES9600304A priority Critical patent/ES2111493B1/en
Publication of ES2111493A1 publication Critical patent/ES2111493A1/en
Application granted granted Critical
Publication of ES2111493B1 publication Critical patent/ES2111493B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVADOS DE 1-[2-(VINILO SUBSTITUIDO)]-5H-2,3-BENZODIAZEPINA, PROCEDIMIENTO DE PREPARACION DE LOS MISMOS, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y UTILIZACIONES CORRESPONDIENTES. LOS COMPUESTOS DE ACUERDO CON LA INVENCION CORRESPONDEN A LA FORMULA GENERAL (I), DONDE A Y B JUNTOS FORMAN UN GRUPO =C=N- O =CH-NH-; R1 REPRESENTA FENILO QUE OPCIONALMENTE LLEVA 2 O 3 GRUPOS HIDROXI O DE 1 A 3 SUBSTITUYENTES IDENTICOS O DIFERENTES SELECCIONADOS ENTRE EL GRUPO CONSISTENTE EN HALOGENO, TRIFLUOROMETILO, NITRO, CIANO, AMINO, ALQUILO (C1-3)AMINO, DI(ALQUILO C1-3)AMINO, (ALCANOILO C1-4)AMINO, ALQUILO C1-4, ALCOXI C1-4, CARBOXI, (ALCOXI C1-4)CARBONILO, (ALCOXI C1-4)CARBONILOXI Y METILENDIOXI; NAFTILO QUE OPCIONALMENTE LLEVA UN SUBSTITUYENTE SELECCIONADO ENTRE EL GRUPO CONSISTENTE EN HIDROXI, ALCOXI C1-4, Y ACILOXI C1-4; FURILO, TIENILO O INDOLILO; R2 REPRESENTA HIDROGENO O ALQUILO C1-4; Y R3 Y R4 SON, INDEPENDIENTEMENTE ENTRE SI, ALCOXI C1-4 UNIDO A LAS POSICIONES 7 Y 8 DEL ANILLO DE BENZODIAZEPINA, O R3 Y R4 JUNTOS FORMAN UN GRUPO 7,8- U 8,9-METILENDIOXI, Y POSEEN ACTIVIDADES VALIOSAS SOBRE EL SISTEMA NERVIOSO CENTRAL.DERIVATIVES OF 1- [2- (SUBSTITUTED VINYL)] - 5H-2,3-BENZODIAZEPINE, PROCEDURE FOR THE PREPARATION OF THE SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND CORRESPONDING USES. THE COMPOUNDS ACCORDING TO THE INVENTION CORRESPOND TO THE GENERAL FORMULA (I), WHERE TO AND B TOGETHER FORM A GROUP = C = N- O = CH-NH-; R1 REPRESENTS PHENYL, WHICH OPTIONALLY CARRIES 2 OR 3 HYDROXY GROUPS OR 1 TO 3 IDENTICAL SUBSTITUTES OR DIFFERENT SELECTED BETWEEN THE GROUP CONSISTING OF HALOGEN, TRIFLUOROMETILE, NITRO, CIAN, ALKYL (1-3) ) AMINO, (ALCANOYL C1-4) AMINO, ALKYL C1-4, ALCOXI C1-4, CARBOXI, (ALCOXI C1-4) CARBONYL, (ALCOXI C1-4) CARBONYLLOXI AND METHYLENDIOXI; NAFTILO THAT OPTIONALLY CARRIES A SELECTED SUBSTITUTE AMONG THE GROUP CONSISTING OF HIDROXI, ALCOXI C1-4, AND ACILOXI C1-4; FURILO, TIENILO OR INDOLILO; R2 REPRESENTS HYDROGEN OR ALKYL C1-4; AND R3 AND R4 ARE, INDEPENDENTLY BETWEEN EACH OTHER, ALCOXI C1-4 ATTACHED TO POSITIONS 7 AND 8 OF THE RING OF BENZODIAZEPINE, OR R3 AND R4 TOGETHER FORM A GROUP 7,8- U 8,9-METHYLENDIOXI, AND HAVE VALUABLE ACTIVITIES ON THE CENTRAL NERVOUS SYSTEM.

ES9600304A 1996-02-08 1996-02-08 DERIVATIVES OF 1- (2- (SUBSTITUTED VINYL)) -5H-2,3-BENZO-DIAZEPINE, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND CORRESPONDING UTILIZATIONS. Expired - Fee Related ES2111493B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9600304A ES2111493B1 (en) 1996-02-08 1996-02-08 DERIVATIVES OF 1- (2- (SUBSTITUTED VINYL)) -5H-2,3-BENZO-DIAZEPINE, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND CORRESPONDING UTILIZATIONS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9600304A ES2111493B1 (en) 1996-02-08 1996-02-08 DERIVATIVES OF 1- (2- (SUBSTITUTED VINYL)) -5H-2,3-BENZO-DIAZEPINE, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND CORRESPONDING UTILIZATIONS.

Publications (2)

Publication Number Publication Date
ES2111493A1 ES2111493A1 (en) 1998-03-01
ES2111493B1 true ES2111493B1 (en) 1999-08-01

Family

ID=8293740

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9600304A Expired - Fee Related ES2111493B1 (en) 1996-02-08 1996-02-08 DERIVATIVES OF 1- (2- (SUBSTITUTED VINYL)) -5H-2,3-BENZO-DIAZEPINE, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND CORRESPONDING UTILIZATIONS.

Country Status (1)

Country Link
ES (1) ES2111493B1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE761315A (en) * 1970-01-12 1971-07-07 S M B Anciens Etablissements J
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ES2111493A1 (en) 1998-03-01

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