ES2110401T3 - Antibioticos pentapeptidicos derivados de dalbaheptidos. - Google Patents
Antibioticos pentapeptidicos derivados de dalbaheptidos.Info
- Publication number
- ES2110401T3 ES2110401T3 ES90113139T ES90113139T ES2110401T3 ES 2110401 T3 ES2110401 T3 ES 2110401T3 ES 90113139 T ES90113139 T ES 90113139T ES 90113139 T ES90113139 T ES 90113139T ES 2110401 T3 ES2110401 T3 ES 2110401T3
- Authority
- ES
- Spain
- Prior art keywords
- antibiotics
- group
- dalbaheptides
- aminoacid
- pentapeptidic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
ANTIBIOTICOS PENTAPEPTIDOS DE FORMULA FIG EN LA QUE W, Z, X1, X2 Y T REPRESENTAN LAS PORCIONES RELATIVAS DE UN ANTIBIOTICO DEL GRUPO DALBAHEPTIDO (ANTIBIOTICOS GLICOPEPTIDOS), Y REPRESENTA UN GRUPO CARBOXIACIDO, UN DERIVADO FUNCIONAL DE DICHO GRUPO CARBOXIACIDO O U GRUPO HIDROMETIL. EL INVENTO INCLUYE LAS SALES DE LOS ANTIBIOTICOS PENTAPEPTIDOS NATES REPRESENTADOS CON LOS ACIDOS O BASES ASI COMO SUS SALES INTERNAS. LOS COMPUESTOS SE OBTIENEN MEDIANTE LA REACCION DE REDUCCION DEL ENLACE PEPTIDO ENTRE EL SEGUNDO Y TERCER AMINOACIDO DE LA CADENA DE 7 AMINOACIDOS DE DALBAHEPTIDOS (ANTIBIOTICOS GLICOPEPTIDOS). EL INVENTO TAMBIEN SE REFIERE AL PROCESO DE REACCION DE REDUCCION QUE IMPLICA EL USO DE UN BOROHIDRIDO METAL ALCALI COMO REAGENTE. EL COMPUESTO MUESTRA UNA ACTIVIDAD ANTIBACTERIANA CONTRA LOS ESTAFILOCOCOS Y LOS ESTREPTOCOCOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP89113132 | 1989-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2110401T3 true ES2110401T3 (es) | 1998-02-16 |
Family
ID=8201636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90113139T Expired - Lifetime ES2110401T3 (es) | 1989-07-18 | 1990-07-10 | Antibioticos pentapeptidicos derivados de dalbaheptidos. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5602229A (es) |
EP (1) | EP0409045B1 (es) |
JP (1) | JP2769028B2 (es) |
KR (1) | KR0145554B1 (es) |
AT (1) | ATE160360T1 (es) |
CA (1) | CA2021379C (es) |
DE (1) | DE69031721T2 (es) |
DK (1) | DK0409045T3 (es) |
ES (1) | ES2110401T3 (es) |
GR (1) | GR3025653T3 (es) |
IE (1) | IE902598A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992010516A1 (en) * | 1990-12-05 | 1992-06-25 | Gruppo Lepetit S.P.A. | 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antibiotics, and a process for preparing them |
ATE121101T1 (de) * | 1990-12-10 | 1995-04-15 | Lepetit Spa | Aus dalbaheptide hergestellte tetrapeptidantibiotika. |
ATE159533T1 (de) * | 1993-05-19 | 1997-11-15 | Biosearch Italia Spa | Syntetische aglukodalbaheptid-antibiotika |
US5684127A (en) * | 1993-06-03 | 1997-11-04 | Gruppo Lepetit Spa | Tetrapeptides deriving from dalbaheptide antibiotics |
CA2250578C (en) | 1996-04-23 | 2003-06-24 | Versicor Inc. | Improved chemical process for preparing amide derivatives of antibiotic a 40926 |
US5952310A (en) * | 1997-05-20 | 1999-09-14 | Eli Lilly And Company | Glycopeptide hexapeptides |
US5919771A (en) * | 1997-05-20 | 1999-07-06 | Eli Lilly And Company | Urea and thiourea derivatives of glycopeptides |
US6710168B1 (en) | 1999-05-19 | 2004-03-23 | The Trustees Of The University Of Princeton | Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same |
WO2000004044A1 (en) * | 1998-07-14 | 2000-01-27 | Princeton University | Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same |
WO2001081373A2 (en) * | 2000-04-25 | 2001-11-01 | Merck & Co., Inc. | Glycopeptide antibacterial compounds and methods of using same |
US6713448B2 (en) | 2001-04-25 | 2004-03-30 | Wyeth Holdings Corporation | Substantially pure glycopeptide antibiotics AC-98-1; AC-98-2; AC-98-3; AC-98-4 and AC-98-5 |
ATE489962T1 (de) * | 2001-04-25 | 2010-12-15 | Wyeth Corp | Im wesentlichen reine glycopeptid-antibiotika ac- 98-1; ac-98-2; ac-98-3; ac-98-4 und ac-98-5 |
US20040241173A1 (en) * | 2002-02-14 | 2004-12-02 | William Marsh Rice University | Fullerene (C60) vancomycin conjugates as improved antibiotics |
WO2005010039A1 (en) * | 2003-07-31 | 2005-02-03 | Pfizer Products Inc. | Bsep polypeptide variants and uses thereof |
WO2007084507A2 (en) * | 2006-01-13 | 2007-07-26 | The Scripps Research Institute | [ψ[CH2NH]PG4] GLYCOPEPTIDE ANTIBIOTIC ANALOGS |
BR112014016548A8 (pt) | 2012-01-06 | 2017-07-04 | Board Of Regents Of The Univ Of Oklahoma | tensoativos baseados em sulfóxido |
ES2702723T3 (es) | 2012-02-09 | 2019-03-05 | Novus Int Inc | Heteroátomos que contienen dímeros cíclicos |
WO2014011857A1 (en) | 2012-07-12 | 2014-01-16 | Novus International Inc. | Matrix and layer compositions for protection of bioactives |
EP3374428A4 (en) | 2015-11-12 | 2019-06-05 | Novus International Inc. | SULFUR COMPOUNDS AS SOLVENTS |
US11147249B2 (en) | 2016-12-08 | 2021-10-19 | Alector Llc | Siglec transgenic mice and methods of use thereof |
US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
US11470827B2 (en) | 2017-12-12 | 2022-10-18 | Alector Llc | Transgenic mice expressing human TREM proteins and methods of use thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3067099A (en) * | 1955-09-16 | 1962-12-04 | Lilly Co Eli | Vancomycin and method for its preparation |
US2990329A (en) * | 1957-02-11 | 1961-06-27 | Abbott Lab | Preparation of ristocetin a salts |
GB1496386A (en) * | 1975-03-05 | 1977-12-30 | Lepetit Spa | Antibiotics |
US4322343A (en) * | 1980-12-18 | 1982-03-30 | Eli Lilly And Company | Pseudo-aglycone of actaplanin |
US4456593A (en) * | 1982-06-22 | 1984-06-26 | Abbott Laboratories | Ristocetin ψ-aglycone as an antibacterial agent |
US4497802A (en) * | 1983-10-21 | 1985-02-05 | Eli Lilly And Company | N-Acyl glycopeptide derivatives |
US4504467A (en) * | 1983-10-21 | 1985-03-12 | Eli Lilly And Company | Glycopeptide derivatives |
US4563442A (en) * | 1983-10-21 | 1986-01-07 | Eli Lilly And Company | Glycopeptide bioconversion products |
US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
US4639433A (en) * | 1985-08-14 | 1987-01-27 | Eli Lilly And Company | Glycopeptide derivatives |
US4643987A (en) * | 1985-08-14 | 1987-02-17 | Eli Lilly And Company | Modified glycopeptides |
GB8701872D0 (en) * | 1987-01-28 | 1987-03-04 | Lepetit Spa | N15-alkyl & n15,n15-dialkyl derivatives |
GB8711066D0 (en) * | 1987-05-11 | 1987-06-17 | Lepetit Spa | Teicoplanin derivatives |
US5438117A (en) * | 1990-12-20 | 1995-08-01 | Gruppo Lepetit S.P.A. | Hexapeptides deriving from aglucoteicoplanin and a process for preparing them |
-
1990
- 1990-07-10 ES ES90113139T patent/ES2110401T3/es not_active Expired - Lifetime
- 1990-07-10 DE DE69031721T patent/DE69031721T2/de not_active Expired - Fee Related
- 1990-07-10 AT AT90113139T patent/ATE160360T1/de not_active IP Right Cessation
- 1990-07-10 DK DK90113139.1T patent/DK0409045T3/da active
- 1990-07-10 EP EP90113139A patent/EP0409045B1/en not_active Expired - Lifetime
- 1990-07-16 KR KR1019900010753A patent/KR0145554B1/ko not_active IP Right Cessation
- 1990-07-17 IE IE259890A patent/IE902598A1/en not_active IP Right Cessation
- 1990-07-17 CA CA002021379A patent/CA2021379C/en not_active Expired - Fee Related
- 1990-07-17 JP JP2187325A patent/JP2769028B2/ja not_active Expired - Fee Related
-
1995
- 1995-05-15 US US08/440,868 patent/US5602229A/en not_active Expired - Fee Related
- 1995-05-31 US US08/454,807 patent/US5648456A/en not_active Expired - Fee Related
-
1997
- 1997-12-10 GR GR970403306T patent/GR3025653T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE160360T1 (de) | 1997-12-15 |
EP0409045A3 (en) | 1991-10-16 |
DE69031721D1 (de) | 1998-01-02 |
IE902598A1 (en) | 1991-02-27 |
DE69031721T2 (de) | 1998-03-19 |
US5648456A (en) | 1997-07-15 |
US5602229A (en) | 1997-02-11 |
KR910002898A (ko) | 1991-02-26 |
EP0409045A2 (en) | 1991-01-23 |
CA2021379C (en) | 2001-03-06 |
JP2769028B2 (ja) | 1998-06-25 |
KR0145554B1 (ko) | 1998-07-15 |
CA2021379A1 (en) | 1991-01-19 |
JPH0352900A (ja) | 1991-03-07 |
EP0409045B1 (en) | 1997-11-19 |
DK0409045T3 (da) | 1997-12-22 |
GR3025653T3 (en) | 1998-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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