ES2109005T3 - Procedimiento de sintesis de acidos nucleicos sobre soporte solido y compuestos utiles en particular como soporte solido en dicho procedimiento. - Google Patents

Procedimiento de sintesis de acidos nucleicos sobre soporte solido y compuestos utiles en particular como soporte solido en dicho procedimiento.

Info

Publication number
ES2109005T3
ES2109005T3 ES94921699T ES94921699T ES2109005T3 ES 2109005 T3 ES2109005 T3 ES 2109005T3 ES 94921699 T ES94921699 T ES 94921699T ES 94921699 T ES94921699 T ES 94921699T ES 2109005 T3 ES2109005 T3 ES 2109005T3
Authority
ES
Spain
Prior art keywords
solid support
procedure
nucleic acid
acid synthesis
epoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94921699T
Other languages
English (en)
Inventor
Ludmilla Baranova
Francois Chatelain
Viktor Kumarev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Biodevelopment SAS
Original Assignee
Genset SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genset SA filed Critical Genset SA
Application granted granted Critical
Publication of ES2109005T3 publication Critical patent/ES2109005T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO DE SINTESIS DE ACIDOS NUCLEICOS EN FASE SOLIDA, CARACTERIZADO EN QUE SE UTILIZA COMO SOPORTE SOLIDO UN POLIMERO MINERAL U ORGANICO CONECTADO POR UN RADICAL HIDROCARBONO DIVALENTE A UN GRUPO EPOXIDO O UN GRUPO DEL TIPO GLICOL, CONSISTIENDO ESTE ULTIMO EN DOS CARBONOS SATURADOS ADYACENTES SOBRE LOS QUE SE ENCUENTRAN SUSTITUIDOS UN GRUPO OH Y UN GRUPO NUCLEOFILO. LA PRESENTE INVENCION SE REFIERE TAMBIEN A COMPUESTOS QUE COMPRENDEN UN GRUPO EPOXIDO O UN GRUPO DEL TIPO GLICOL TAL COMO SE DEFINE ARRIBA UTIL PARTICULARMENTE COMO SOPORTE SOLIDO EN UN PROCESO DE SINTESIS DE ACIDOS NUCLEICOS SOBRE SOPORTE SOLIDO.
ES94921699T 1993-07-09 1994-07-07 Procedimiento de sintesis de acidos nucleicos sobre soporte solido y compuestos utiles en particular como soporte solido en dicho procedimiento. Expired - Lifetime ES2109005T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9308498A FR2707296B1 (fr) 1993-07-09 1993-07-09 Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé.

Publications (1)

Publication Number Publication Date
ES2109005T3 true ES2109005T3 (es) 1998-01-01

Family

ID=9449129

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94921699T Expired - Lifetime ES2109005T3 (es) 1993-07-09 1994-07-07 Procedimiento de sintesis de acidos nucleicos sobre soporte solido y compuestos utiles en particular como soporte solido en dicho procedimiento.

Country Status (14)

Country Link
EP (1) EP0707592B1 (es)
JP (1) JPH08512306A (es)
KR (1) KR960703937A (es)
AT (1) ATE157668T1 (es)
AU (1) AU696421B2 (es)
CA (1) CA2166765A1 (es)
DE (1) DE69405396T2 (es)
DK (1) DK0707592T3 (es)
ES (1) ES2109005T3 (es)
FR (1) FR2707296B1 (es)
GR (1) GR3025420T3 (es)
HK (1) HK1002731A1 (es)
TW (1) TW397839B (es)
WO (1) WO1995001987A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714061B1 (fr) * 1993-12-16 1996-03-08 Genset Sa Procédé de préparation de polynucléotides sur support solide et appareil permettant sa mise en Óoeuvre.
US5869696A (en) * 1996-04-22 1999-02-09 Beckman Instruments, Inc. Universal solid supports and methods for their use
US6590092B1 (en) 1998-05-19 2003-07-08 Nam Q. Ngo Process for preparing a “universal support” and the reagents used for generating such support
DE69814097T2 (de) * 1998-12-02 2004-04-08 Council Of Scientific And Industrial Research Universale Polymere Träger zur Synthese von Oligonukleotiden
WO2000047771A2 (en) 1999-02-12 2000-08-17 Genset Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism
AU2942100A (en) * 1999-03-11 2000-09-28 Kuraray Co., Ltd. Vitamin d derivatives and process for the preparation thereof
EP1132739B1 (en) * 2000-05-16 2001-09-26 BioChip Technologies GmbH Linker system for activating surfaces for bioconjugation and methods for their use
US7211654B2 (en) 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
EP1925672A1 (en) 2001-06-22 2008-05-28 Syngeta Participations AG Abiotic stress responsive polynucleotides and polypeptides
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
ES2337989T3 (es) 2001-12-18 2010-05-03 Endocube Sas Nuevas proteinas asociadas a la muerte de la familia thap y rutas par4 relacionadas implicadas en el control de la apoptosis.
AU2003214558A1 (en) 2002-03-13 2003-09-22 Bayer Cropscience Sa Mutagenesis of aspergillus fungi and identification of genes essential for growth
FR2900415B1 (fr) 2006-04-28 2010-08-13 Agronomique Inst Nat Rech Systeme genetique pour le controle du developpement du type floral d'une plante dicotyledone, et mise en oeuvre dans les procedes de detection et de selection
FR2954349A1 (fr) 2009-12-22 2011-06-24 Agronomique Inst Nat Rech Sulfatase modifiant selectivement les glycosaminoglycanes
EP4050109A1 (en) 2010-08-18 2022-08-31 Fred Hutchinson Cancer Center Agents for use in treating facioscapulohumeral dystrophy (fshd)
US10781175B2 (en) 2016-07-15 2020-09-22 Am Chemicals Llc Solid supports and phosphoramidite building blocks for oligonucleotide conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155950B1 (en) * 1983-09-02 1990-01-17 Molecular Biosystems, Inc. Oligonucleotide polymeric support system
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
WO1991000868A1 (en) * 1989-07-07 1991-01-24 National Research Development Corporation Immobilised polynucleotides
EP0504321B1 (en) * 1989-12-04 1997-05-07 Microprobe Corporation Enhanced capture of target nucleic acid by the use of oligonucleotides covalently attached to polymers
DK0592434T3 (da) * 1990-10-26 1999-06-21 Genta Inc Forbedret fremgangsmåde til syntese af oligomerer
EP0554407A1 (en) * 1990-10-26 1993-08-11 Genta Incorporated Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers

Also Published As

Publication number Publication date
ATE157668T1 (de) 1997-09-15
EP0707592B1 (fr) 1997-09-03
JPH08512306A (ja) 1996-12-24
GR3025420T3 (en) 1998-02-27
KR960703937A (ko) 1996-08-31
CA2166765A1 (fr) 1995-01-19
WO1995001987A1 (fr) 1995-01-19
TW397839B (en) 2000-07-11
FR2707296B1 (fr) 1995-09-29
FR2707296A1 (fr) 1995-01-13
EP0707592A1 (fr) 1996-04-24
DK0707592T3 (da) 1998-03-30
DE69405396D1 (de) 1997-10-09
AU7230994A (en) 1995-02-06
AU696421B2 (en) 1998-09-10
HK1002731A1 (en) 1998-09-11
DE69405396T2 (de) 1998-03-26

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