ES2105923B1 - Composiciones para el tratamiento de una infeccion y una enfermedad causadas por el virus de la hepatitis b (hbv). - Google Patents
Composiciones para el tratamiento de una infeccion y una enfermedad causadas por el virus de la hepatitis b (hbv).Info
- Publication number
- ES2105923B1 ES2105923B1 ES09300698A ES9300698A ES2105923B1 ES 2105923 B1 ES2105923 B1 ES 2105923B1 ES 09300698 A ES09300698 A ES 09300698A ES 9300698 A ES9300698 A ES 9300698A ES 2105923 B1 ES2105923 B1 ES 2105923B1
- Authority
- ES
- Spain
- Prior art keywords
- fiau
- metabolite
- compositions
- hbv
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
COMPOSICIONES PARA EL TRATAMIENTO DE UNA INFECCION Y UNA ENFERMEDAD CAUSADAS POR EL VIRUS DE LA HEPATITIS B (HBV). COMPRENDEN 1-(2 -DESOXI-2-FLUORO-BE-D-ARABINOFURANOSIL)-5-YODOURACILO (FIAU) DE FORMULA FORMULA UN PROFARMACO DE FIAU O UN METABOLITO DE FIAU, EN CANTIDAD SUFICIENTE PARA PROPORCIONAR UNA DOSIS BAJA, PERO ANTIVIRICAMENTE EFICAZ DE FIAU, SU PROFARMACO O METABOLITO, COMPRENDIDA EN EL INTERVALO DE 0,05 A 1 MG/KG-DIA, Y UN VEHICULO FARMACEUTICAMENTE ACEPTABLE. ESTAS COMPOSICIONES SE PREPARAN MEZCLANDO EL VEHICULO CON EL COMPUESTO FIAU, SU PROFARMACO O METABOLITO PARA PROPORCIONAR DICHA DOSIS BAJA, ASI COMO UNA CONCENTRACION MAXIMA DE FIAU, SU PROFARMACO O METABOLITO EN PLASMA COMPRENDIDA EN EL INTERVALO DE 0,1 A 1, MIG/ML O UNA CANTIDAD DE 0,25, 0,5, 1, 5 O 10 MG DE FIAU, SU PROFARMACO O METABOLITO EN LA COMPOSICION OBTENIDA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86389092A | 1992-04-06 | 1992-04-06 | |
US95292792A | 1992-09-25 | 1992-09-25 | |
US07/959,004 US5432165A (en) | 1992-04-06 | 1992-10-09 | Methods for the treatment of infection caused by Hepatitis B virus (HBV) |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2105923A1 ES2105923A1 (es) | 1997-10-16 |
ES2105923B1 true ES2105923B1 (es) | 1998-07-01 |
Family
ID=27420427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09300698A Expired - Lifetime ES2105923B1 (es) | 1992-04-06 | 1993-04-05 | Composiciones para el tratamiento de una infeccion y una enfermedad causadas por el virus de la hepatitis b (hbv). |
Country Status (26)
Country | Link |
---|---|
US (1) | US5432165A (es) |
EP (1) | EP0565412A1 (es) |
JP (1) | JPH069403A (es) |
CN (1) | CN1081879A (es) |
AP (1) | AP372A (es) |
AU (1) | AU662804B2 (es) |
BE (1) | BE1009181A5 (es) |
BR (1) | BR9306207A (es) |
CA (1) | CA2092356A1 (es) |
EE (1) | EE9400068A (es) |
ES (1) | ES2105923B1 (es) |
FR (1) | FR2689398B1 (es) |
GR (1) | GR930100111A (es) |
IL (1) | IL105169A0 (es) |
IT (1) | IT1264332B1 (es) |
LV (1) | LV10191B (es) |
MD (1) | MD940152A (es) |
MX (1) | MX9301922A (es) |
NO (1) | NO931246L (es) |
NZ (1) | NZ247188A (es) |
OA (1) | OA10102A (es) |
PH (1) | PH31116A (es) |
PT (1) | PT101238A (es) |
SI (1) | SI9300144A (es) |
WO (1) | WO1993019762A1 (es) |
YU (1) | YU23993A (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5827727A (en) * | 1990-02-01 | 1998-10-27 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
US6200952B1 (en) * | 1993-06-02 | 2001-03-13 | Sciclone Pharmaceuticals, Inc. | Combination therapy method for treating chronic hepatitis B |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
WO1996010649A1 (en) * | 1994-09-30 | 1996-04-11 | Southwest Foundation For Biomedical Research | Isolated human hepatitis b virus polymerase and uses thereof |
US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
US6296882B1 (en) * | 2000-06-12 | 2001-10-02 | Manuel Viamonte, Jr. | Non-toxic mucosal disinfectant containing isopropyl alcohol, sesame oil, and lemon oil |
US8076303B2 (en) | 2005-12-13 | 2011-12-13 | Spring Bank Pharmaceuticals, Inc. | Nucleotide and oligonucleotide prodrugs |
JP2012526149A (ja) * | 2009-05-08 | 2012-10-25 | サイクローン・ファーマシューティカルズ・インコーポレイテッド | ワクチン増強剤としてのαチモシンペプチド |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE147774C (es) * | ||||
US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
US4594339A (en) * | 1982-04-06 | 1986-06-10 | Sloan-Kettering Institute For Cancer Research | Anti-herpes virus compositions containing 5-substituted 1-2'(deoxy-2-'-substituted-β-d-arabinofuranosyl)pyrimedene nucleosides |
US4666892A (en) * | 1984-03-06 | 1987-05-19 | Sloan-Kettering Memorial Cancer Center | Method and composition for hepatitis treatment with pyrimidine nucleoside compounds |
-
1992
- 1992-10-09 US US07/959,004 patent/US5432165A/en not_active Expired - Fee Related
-
1993
- 1993-03-18 NZ NZ247188A patent/NZ247188A/en unknown
- 1993-03-18 AU AU35302/93A patent/AU662804B2/en not_active Ceased
- 1993-03-19 GR GR930100111A patent/GR930100111A/el unknown
- 1993-03-24 CA CA002092356A patent/CA2092356A1/en not_active Abandoned
- 1993-03-25 SI SI9300144A patent/SI9300144A/sl unknown
- 1993-03-25 PT PT101238A patent/PT101238A/pt not_active Application Discontinuation
- 1993-03-25 IL IL105169A patent/IL105169A0/xx unknown
- 1993-03-31 NO NO93931246A patent/NO931246L/no unknown
- 1993-04-02 MX MX9301922A patent/MX9301922A/es not_active Application Discontinuation
- 1993-04-02 EP EP93400854A patent/EP0565412A1/en not_active Withdrawn
- 1993-04-02 AP APAP/P/1993/000513A patent/AP372A/en active
- 1993-04-05 BE BE9300337A patent/BE1009181A5/fr not_active IP Right Cessation
- 1993-04-05 WO PCT/US1993/003194 patent/WO1993019762A1/en active Search and Examination
- 1993-04-05 FR FR9303979A patent/FR2689398B1/fr not_active Expired - Fee Related
- 1993-04-05 BR BR9306207A patent/BR9306207A/pt not_active Application Discontinuation
- 1993-04-05 ES ES09300698A patent/ES2105923B1/es not_active Expired - Lifetime
- 1993-04-05 IT IT93TO000226A patent/IT1264332B1/it active IP Right Grant
- 1993-04-05 PH PH45997A patent/PH31116A/en unknown
- 1993-04-06 YU YU23993A patent/YU23993A/sh unknown
- 1993-04-06 JP JP5079849A patent/JPH069403A/ja active Pending
- 1993-04-06 LV LVP-93-231A patent/LV10191B/en unknown
- 1993-04-06 CN CN93105728A patent/CN1081879A/zh active Pending
-
1994
- 1994-06-17 MD MD94-0152A patent/MD940152A/ro not_active Application Discontinuation
- 1994-06-29 EE EE9400068A patent/EE9400068A/xx unknown
- 1994-10-05 OA OA60568A patent/OA10102A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO1993019762A1 (en) | 1993-10-14 |
IL105169A0 (en) | 1993-07-08 |
NO931246D0 (no) | 1993-03-31 |
AP372A (en) | 1994-11-24 |
ITTO930226A1 (it) | 1994-10-05 |
MD940152A (ro) | 1995-12-31 |
PH31116A (en) | 1998-02-28 |
CN1081879A (zh) | 1994-02-16 |
EE9400068A (et) | 1995-12-15 |
LV10191B (en) | 1995-04-20 |
EP0565412A1 (en) | 1993-10-13 |
AP9300513A0 (en) | 1993-04-30 |
JPH069403A (ja) | 1994-01-18 |
FR2689398B1 (fr) | 1994-11-18 |
BE1009181A5 (fr) | 1996-12-03 |
NO931246L (no) | 1993-10-07 |
US5432165A (en) | 1995-07-11 |
FR2689398A1 (fr) | 1993-10-08 |
IT1264332B1 (it) | 1996-09-23 |
NZ247188A (en) | 1995-05-26 |
GR930100111A (el) | 1993-12-30 |
ES2105923A1 (es) | 1997-10-16 |
OA10102A (en) | 1996-12-18 |
BR9306207A (pt) | 1998-06-23 |
MX9301922A (es) | 1993-10-01 |
AU662804B2 (en) | 1995-09-14 |
AU3530293A (en) | 1993-10-07 |
LV10191A (lv) | 1994-10-20 |
PT101238A (pt) | 1994-03-31 |
ITTO930226A0 (it) | 1993-04-05 |
SI9300144A (en) | 1994-03-31 |
YU23993A (sh) | 1997-05-28 |
CA2092356A1 (en) | 1993-10-07 |
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