ES2102364T3 - Membranas receptoras y control del paso a su traves por medio de ionoforos. - Google Patents
Membranas receptoras y control del paso a su traves por medio de ionoforos.Info
- Publication number
- ES2102364T3 ES2102364T3 ES90902588T ES90902588T ES2102364T3 ES 2102364 T3 ES2102364 T3 ES 2102364T3 ES 90902588 T ES90902588 T ES 90902588T ES 90902588 T ES90902588 T ES 90902588T ES 2102364 T3 ES2102364 T3 ES 2102364T3
- Authority
- ES
- Spain
- Prior art keywords
- membrane
- ionophoric
- components
- analyte
- molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012528 membrane Substances 0.000 title abstract 8
- 239000002555 ionophore Substances 0.000 title 1
- 230000000236 ionophoric effect Effects 0.000 abstract 4
- 239000012491 analyte Substances 0.000 abstract 3
- ZWCXYZRRTRDGQE-SORVKSEFSA-N gramicidina Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 ZWCXYZRRTRDGQE-SORVKSEFSA-N 0.000 abstract 2
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- 102100035140 Vitronectin Human genes 0.000 abstract 1
- 108010031318 Vitronectin Proteins 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0076—Chemical modification of the substrate
- A61L33/0082—Chemical modification of the substrate by reacting with an organic compound other than heparin
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/12—Composite membranes; Ultra-thin membranes
- B01D69/122—Separate manufacturing of ultra-thin membranes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/14—Dynamic membranes
- B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/5432—Liposomes or microcapsules
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/438—Antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/442—Colorants, dyes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/48—Antimicrobial properties
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/89—Deposition of materials, e.g. coating, cvd, or ald
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/931—Medical device coating
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pathology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Nanotechnology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Surgery (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Dispersion Chemistry (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Composite Materials (AREA)
- Peptides Or Proteins (AREA)
Abstract
LA INVENCION PRESENTA UNA MEMBRANA CUYA CONDUCTIVIDAD DEPENDE DE LA PRESENCIA O AUSENCIA DE UN ANALITO. LA MEMBRANA CONSTA DE UNA RED ESTRECHAMENTE EMPAQUETADA DE MOLECULAS ANFIFILICAS QUE SE AUTOAGRUPAN Y DOS COMPONENTES IONOFORICOS. EN UNO DE LOS COMPONENTES IONOFORICOS HAY UNA MOLECULA RECEPTORA QUE REACCIONA CON EL ANALITO. EL ENLACE DEL ANALITO A LA MOLECULA RECEPTORA ORIGINA UN CAMBIO EN LA RELACION ENTRE LOS COMPONENTES IONOFORICOS DE MODO QUE EL FLUJO DE IONES A TRAVES DE LA MEMBRANA BIEN SE EVITA O SE PERMITE. LOS COMPONENTES IONOFORICOS SE SELECCIONAN PREFERIBLEMENTE DEL GRUPO QUE CONSISTE EN ANFOTERICINA B, MONOMEROS DE GRAMICIDINA A Y COMBINACIONES DE LOS MISMOS, SIENDO PARTICULARMENTE PREFERIDOS LOS MONOMEROS DE GRAMIDICINA A. LA INVENCION TAMBIEN PRESENTA UNA MEMBRANA QUE TIENE RECEPTORES DIRIGIDOS CONTRA LA REGION FC DE ANTICUERPOS. ESTOS RECEPTORES SE DERIVAN PREFERIBLEMENTE DE ANTICUERPOS POLICLONALES. ESTAS MEMBRANAS PROPORCIONAN UNA SUPERFICIE "GENERICA" QUE ENLAZARA ANTICUERPOS DE UNA MANERA TAL QUE LAS REGIONES ENLAZADORAS DE ANTIGENOS DEL ANTICUERPO NO ESTEN OCULTAS. LA INVENCION PRESENTA ADEMAS UN DISPOSITIVO ADAPTADO PARA SER IMPLANTADO EN EL CUERPO DE UN MAMIFERO, QUE SE CARACTERIZA PORQUE ESTA RECUBIERTO DE UNA MEMBRANA QUE TIENE UNA RED ESTRECHAMENTE EMPAQUETADA DE MOLECULAS ANFIFILICAS QUE SE AUTOAGRUPAN Y MOLECULAS RECEPTORAS, SIENDO LAS MOLECULAS RECEPTORAS TALES QUE EL AGRUPAMIENTO DE LAS CELULAS ESPECIFICAS A LA MEMBRANA ES AUMENTADO O EVITADO. SE PREFIERE, DE UNA MANERA MUY PARTICULAR, QUE LAS MOLECULAS RECEPTORAS SEAN DIRIGIDAS CONTRA LIBRONECTINA, VITRONECTINA, CELULAS ENDOTELIALES O CELULAS EPITELIALES. SE PREFIERE AUN MAS QUE LA MEMBRANA QUE RECUBRE EL DISPOSITIVO TENGA VARIOS CANALES DE IONES COMO POR EJEMPLO GRAMICIDINA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPJ244189 | 1989-01-27 | ||
AUPJ247089 | 1989-01-30 | ||
AUPJ246989 | 1989-01-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2102364T3 true ES2102364T3 (es) | 1997-08-01 |
Family
ID=27157477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90902588T Expired - Lifetime ES2102364T3 (es) | 1989-01-27 | 1990-01-29 | Membranas receptoras y control del paso a su traves por medio de ionoforos. |
Country Status (8)
Country | Link |
---|---|
US (2) | US5443955A (es) |
EP (2) | EP0770874A3 (es) |
JP (2) | JP2927942B2 (es) |
AT (1) | ATE153673T1 (es) |
CA (1) | CA2045640C (es) |
DE (1) | DE69030811T2 (es) |
ES (1) | ES2102364T3 (es) |
WO (1) | WO1990008783A1 (es) |
Families Citing this family (133)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0382736B1 (en) * | 1987-07-27 | 1994-11-02 | Commonwealth Scientific And Industrial Research Organisation | Receptor membranes |
US5328847A (en) * | 1990-02-20 | 1994-07-12 | Case George D | Thin membrane sensor with biochemical switch |
FR2688065B1 (fr) * | 1992-02-28 | 1994-12-23 | Thomson Csf | Capteur moleculaire. |
US5674698A (en) * | 1992-09-14 | 1997-10-07 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
EP1106998A3 (en) * | 1992-10-01 | 2001-07-18 | Australian Membrane And Biotechnology Research Institute | Improved sensor membranes |
GB9300479D0 (en) * | 1993-01-07 | 1993-03-03 | Pasternak Charles A | Currents in narrow pores |
CA2161084C (en) * | 1993-04-21 | 2005-01-25 | Bruce Andrew Cornell | Surface amplifier |
AUPM950094A0 (en) * | 1994-11-16 | 1994-12-08 | Australian Membrane And Biotechnology Research Institute | Detection device and method |
US5798030A (en) * | 1995-05-17 | 1998-08-25 | Australian Membrane And Biotechnology Research Institute | Biosensor membranes |
US5879878A (en) * | 1995-06-20 | 1999-03-09 | Australian Membrane And Biotechnology Research Institute | Method of producing a first layer electrode membrane for a biosensor |
AUPN366995A0 (en) * | 1995-06-20 | 1995-07-13 | Australian Membrane And Biotechnology Research Institute | Self-assembly of bilayer membrane sensors |
AUPN366895A0 (en) * | 1995-06-20 | 1995-07-13 | Australian Membrane And Biotechnology Research Institute | Detection of small analytes |
AUPN980796A0 (en) * | 1996-05-13 | 1996-06-06 | Australian Membrane And Biotechnology Research Institute | Improved reservoir components |
JP2000513811A (ja) * | 1996-05-22 | 2000-10-17 | オーストラリアン メンブレイン アンド バイオテクノロジィ リサーチ インスティチュート | 核酸センサー |
US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
US8172897B2 (en) | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
US6046008A (en) * | 1997-04-24 | 2000-04-04 | Ia, Inc. | Immunologically based strip test utilizing ionophore membranes |
US6171232B1 (en) * | 1997-06-26 | 2001-01-09 | Cordis Corporation | Method for targeting in vivo nitric oxide release |
CA2298540A1 (en) | 1997-08-20 | 1999-02-25 | David J. Julius | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
EP1040349B2 (de) | 1997-12-17 | 2012-12-19 | Ecole Polytechnique Federale De Lausanne (Epfl) | Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern |
US7244349B2 (en) * | 1997-12-17 | 2007-07-17 | Molecular Devices Corporation | Multiaperture sample positioning and analysis system |
US20020144905A1 (en) | 1997-12-17 | 2002-10-10 | Christian Schmidt | Sample positioning and analysis system |
SG71881A1 (en) * | 1998-01-08 | 2000-04-18 | Microsense Cardiovascular Sys | Method and device for fixation of a sensor in a bodily lumen |
GB9801120D0 (en) * | 1998-01-21 | 1998-03-18 | Secr Defence | Detection system |
US6221425B1 (en) | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
WO1999052574A1 (en) * | 1998-04-10 | 1999-10-21 | Massachusetts Institute Of Technology | Biopolymers resistant coatings |
WO1999053955A1 (en) * | 1998-04-22 | 1999-10-28 | Desmos, Inc. | Creation of bioactive surfaces through selective adsorption |
GB9812783D0 (en) * | 1998-06-12 | 1998-08-12 | Cenes Ltd | High throuoghput screen |
WO2000011152A1 (en) * | 1998-08-25 | 2000-03-02 | University Of Washington | Streptavidin mutants having secondary functional domains |
US7125578B1 (en) * | 1999-04-23 | 2006-10-24 | Los Alamos National Security, Llc | Photoinduced charge-transfer materials for nonlinear optical applications |
EP1255772A2 (en) * | 2000-02-11 | 2002-11-13 | The Texas A & M University System | Biosensor compositions and methods of use |
US6541071B1 (en) | 2000-03-23 | 2003-04-01 | Corning Incorporated | Method for fabricating supported bilayer-lipid membranes |
US7270730B2 (en) | 2000-08-04 | 2007-09-18 | Essen Instruments, Inc. | High-throughput electrophysiological measurement system |
US7067046B2 (en) * | 2000-08-04 | 2006-06-27 | Essen Instruments, Inc. | System for rapid chemical activation in high-throughput electrophysiological measurements |
EP1269993A1 (en) * | 2001-06-21 | 2003-01-02 | Applied NanoSystems B.V. | Delivery of small hydrophilic molecules packaged into lipid vesicles |
US7285304B1 (en) | 2003-06-25 | 2007-10-23 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
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- 1990-01-29 ES ES90902588T patent/ES2102364T3/es not_active Expired - Lifetime
- 1990-01-29 WO PCT/AU1990/000025 patent/WO1990008783A1/en active IP Right Grant
- 1990-01-29 EP EP96203120A patent/EP0770874A3/en not_active Withdrawn
- 1990-01-29 US US07/721,431 patent/US5443955A/en not_active Expired - Lifetime
- 1990-01-29 JP JP2502496A patent/JP2927942B2/ja not_active Expired - Fee Related
- 1990-01-29 DE DE69030811T patent/DE69030811T2/de not_active Expired - Fee Related
- 1990-01-29 EP EP90902588A patent/EP0455705B1/en not_active Expired - Lifetime
- 1990-01-29 CA CA002045640A patent/CA2045640C/en not_active Expired - Lifetime
- 1990-01-29 AT AT90902588T patent/ATE153673T1/de not_active IP Right Cessation
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1996
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CA2045640A1 (en) | 1990-07-28 |
WO1990008783A1 (en) | 1990-08-09 |
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US5443955A (en) | 1995-08-22 |
EP0455705B1 (en) | 1997-05-28 |
US5840083A (en) | 1998-11-24 |
EP0770874A3 (en) | 1998-01-21 |
CA2045640C (en) | 1999-01-05 |
EP0455705A4 (en) | 1992-09-16 |
JPH11316210A (ja) | 1999-11-16 |
DE69030811T2 (de) | 1997-10-02 |
EP0455705A1 (en) | 1991-11-13 |
DE69030811D1 (de) | 1997-07-03 |
JPH04504714A (ja) | 1992-08-20 |
EP0770874A2 (en) | 1997-05-02 |
JP3293793B2 (ja) | 2002-06-17 |
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