ES2102312A1 - Procedimiento para la cristalizacion del iopamidol. - Google Patents
Procedimiento para la cristalizacion del iopamidol.Info
- Publication number
- ES2102312A1 ES2102312A1 ES09401679A ES9401679A ES2102312A1 ES 2102312 A1 ES2102312 A1 ES 2102312A1 ES 09401679 A ES09401679 A ES 09401679A ES 9401679 A ES9401679 A ES 9401679A ES 2102312 A1 ES2102312 A1 ES 2102312A1
- Authority
- ES
- Spain
- Prior art keywords
- iopamidol
- crystallization
- pharmacopoeia
- butanol
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA CRISTALIZACION DEL IOPAMIDOL UTILIZANDO BUTANOL COMO DISOLVENTE. EL IOPAMIDOL SE OBTIENE CON GRAN RENDIMIENTO A PARTIR DE SOLUCIONES ACUOSAS DEL MISMO Y TIENE CARACTERISTICAS QUE ESTAN DE ACUERDO CON LAS REQUERIDAS POR LA FARMACOPEA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI931720A IT1257001B (it) | 1993-07-30 | 1993-07-30 | Processo per la cristalizzazione dello iopamidolo |
IT000760 IT1269339B (it) | 1994-04-20 | 1994-04-20 | Processo per la cristallizzazione dello iopamidolo |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2102312A1 true ES2102312A1 (es) | 1997-07-16 |
ES2102312B1 ES2102312B1 (es) | 1998-04-01 |
Family
ID=26331032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09401679A Expired - Fee Related ES2102312B1 (es) | 1993-07-30 | 1994-07-29 | Procedimiento para la cristalizacion del iopamidol |
Country Status (29)
Country | Link |
---|---|
US (3) | US5571941A (es) |
JP (1) | JP3299045B2 (es) |
KR (1) | KR100355211B1 (es) |
CN (1) | CN1035940C (es) |
AT (1) | AT404832B (es) |
AU (1) | AU690138B2 (es) |
BE (1) | BE1008403A4 (es) |
CA (1) | CA2128942C (es) |
CH (1) | CH686783A5 (es) |
CZ (1) | CZ289300B6 (es) |
DE (1) | DE4426818A1 (es) |
DK (1) | DK172074B1 (es) |
ES (1) | ES2102312B1 (es) |
FI (1) | FI960400A (es) |
FR (1) | FR2708601B1 (es) |
GB (1) | GB2280436B (es) |
GR (1) | GR940100366A (es) |
HU (1) | HU217023B (es) |
IE (1) | IE80675B1 (es) |
IL (1) | IL110391A (es) |
NL (1) | NL194272C (es) |
NO (1) | NO304226B1 (es) |
NZ (1) | NZ271632A (es) |
PT (1) | PT101554B (es) |
RU (1) | RU2135462C1 (es) |
SE (1) | SE9402595L (es) |
SI (1) | SI9420046B (es) |
WO (1) | WO1995004031A1 (es) |
ZA (1) | ZA945472B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL110391A (en) | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the formation of infamidol |
US6310243B1 (en) * | 1994-09-23 | 2001-10-30 | Nycomed Imaging As | Iodinated x-ray contrast media |
PT101720A (pt) * | 1995-06-08 | 1997-01-31 | Hovione Sociedade Quimica S A | Processo para a purificacao e cristalizacao de iopamidol |
EP0842141A1 (en) * | 1995-07-04 | 1998-05-20 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylen-glycol |
CZ288645B6 (cs) * | 1995-09-08 | 2001-08-15 | Bracco International B. V. | Způsob krystalizace Iopamidolu |
PT101919B (pt) * | 1996-09-30 | 2000-01-31 | Hovione Sociedade Quimica Sa | Um processo para a purificacao de tohexol |
ES2141691T3 (es) * | 1997-02-11 | 2003-05-16 | Bracco Int Bv | Procedimiento para la cristalizacion de (s)-n,n'-bis(2-hidroxi-1-(hidroximetil)etil)-5-((2-hidroxi-1-oxopropil)amino)-2,4,6-triyodo-1,3-bencenodicarboxamida en un alcohol (c5-c6) lineal o ramificado o sus mezclas. |
GB9720969D0 (en) | 1997-10-02 | 1997-12-03 | Nycomed Imaging As | Process |
KR20000031642A (ko) * | 1998-11-09 | 2000-06-05 | 강재헌 | 이오파미돌의 결정화 방법 |
US6265610B1 (en) | 1999-01-12 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Contrast media for angiography |
US6803485B2 (en) | 1999-02-26 | 2004-10-12 | Bracco Imaging S.P.A. | Process for the preparation of iopamidol |
IT1319671B1 (it) | 2000-12-01 | 2003-10-23 | Bracco Spa | Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino) |
DE102005059191B4 (de) * | 2005-12-05 | 2008-02-07 | Bayer Schering Pharma Ag | Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen |
KR100976097B1 (ko) * | 2008-12-05 | 2010-08-16 | 주식회사 대웅제약 | 이오프로마이드의 z 이성체를 선택적으로 결정화하는 방법 |
AU2010232556A1 (en) * | 2009-04-02 | 2011-11-03 | Allergan, Inc. | Prostaglandin E receptor antagonists |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
DE102012104679A1 (de) | 2011-05-30 | 2012-12-06 | Westfälische Wilhelms-Universität Münster | Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli |
JP6342421B2 (ja) | 2012-12-19 | 2018-06-13 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | X線造影剤の精製 |
KR102128423B1 (ko) * | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1472050A (en) * | 1974-12-13 | 1977-04-27 | Savac Ag | Non-ionic x-ray contrast agents |
US4352788A (en) * | 1979-08-09 | 1982-10-05 | Bracco Industria Chimica S.P.A. | Derivatives of 2,4,6-triiodo-isophthalic acid, processes for their synthesis and X-ray contrasting materials containing these |
WO1988009328A1 (en) * | 1987-05-22 | 1988-12-01 | Bracco Industria Chimica S.P.A. | Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives |
US5204086A (en) * | 1982-10-01 | 1993-04-20 | Nycomed Imaging As | X-ray contrast agent |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
DE3150916A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" |
IT1248741B (it) * | 1991-02-26 | 1995-01-26 | Bracco Spa | Processo di concentrazione e di purificazione di composti organici |
IL110391A (en) | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the formation of infamidol |
-
1994
- 1994-07-20 IL IL11039194A patent/IL110391A/en not_active IP Right Cessation
- 1994-07-22 RU RU96105070A patent/RU2135462C1/ru active
- 1994-07-22 GR GR940100366A patent/GR940100366A/el unknown
- 1994-07-22 NZ NZ271632A patent/NZ271632A/en not_active IP Right Cessation
- 1994-07-22 AU AU75321/94A patent/AU690138B2/en not_active Expired
- 1994-07-22 WO PCT/EP1994/002415 patent/WO1995004031A1/en active Application Filing
- 1994-07-22 SI SI9420046A patent/SI9420046B/sl unknown
- 1994-07-22 KR KR1019960700580A patent/KR100355211B1/ko not_active IP Right Cessation
- 1994-07-22 CN CN94192930A patent/CN1035940C/zh not_active Expired - Lifetime
- 1994-07-22 HU HU9600191A patent/HU217023B/hu unknown
- 1994-07-25 GB GB9414912A patent/GB2280436B/en not_active Expired - Lifetime
- 1994-07-25 ZA ZA945472A patent/ZA945472B/xx unknown
- 1994-07-26 NL NL9401229A patent/NL194272C/nl not_active IP Right Cessation
- 1994-07-26 PT PT101554A patent/PT101554B/pt not_active IP Right Cessation
- 1994-07-26 FR FR9409238A patent/FR2708601B1/fr not_active Expired - Lifetime
- 1994-07-26 CH CH02354/94A patent/CH686783A5/it not_active IP Right Cessation
- 1994-07-27 CA CA002128942A patent/CA2128942C/en not_active Expired - Lifetime
- 1994-07-28 DE DE4426818A patent/DE4426818A1/de not_active Ceased
- 1994-07-29 US US08/281,985 patent/US5571941A/en not_active Ceased
- 1994-07-29 CZ CZ19941831A patent/CZ289300B6/cs not_active IP Right Cessation
- 1994-07-29 ES ES09401679A patent/ES2102312B1/es not_active Expired - Fee Related
- 1994-07-29 BE BE9400717A patent/BE1008403A4/fr not_active IP Right Cessation
- 1994-07-29 JP JP17811594A patent/JP3299045B2/ja not_active Expired - Lifetime
- 1994-07-29 SE SE9402595A patent/SE9402595L/xx not_active Application Discontinuation
- 1994-07-29 AT AT0150594A patent/AT404832B/de not_active IP Right Cessation
- 1994-07-29 IE IE940609A patent/IE80675B1/en not_active IP Right Cessation
- 1994-07-29 DK DK089294A patent/DK172074B1/da not_active IP Right Cessation
-
1996
- 1996-01-29 FI FI960400A patent/FI960400A/fi not_active Application Discontinuation
- 1996-01-29 NO NO960376A patent/NO304226B1/no not_active IP Right Cessation
-
1997
- 1997-02-07 US US08/797,610 patent/USRE36433E/en not_active Expired - Lifetime
-
1998
- 1998-08-25 US US09/139,894 patent/US6506938B1/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1472050A (en) * | 1974-12-13 | 1977-04-27 | Savac Ag | Non-ionic x-ray contrast agents |
US4352788A (en) * | 1979-08-09 | 1982-10-05 | Bracco Industria Chimica S.P.A. | Derivatives of 2,4,6-triiodo-isophthalic acid, processes for their synthesis and X-ray contrasting materials containing these |
US5204086A (en) * | 1982-10-01 | 1993-04-20 | Nycomed Imaging As | X-ray contrast agent |
WO1988009328A1 (en) * | 1987-05-22 | 1988-12-01 | Bracco Industria Chimica S.P.A. | Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19970716 Kind code of ref document: A1 Effective date: 19970716 |
|
PC2A | Transfer of patent | ||
FD2A | Announcement of lapse in spain |
Effective date: 20141120 |