ES2101655A1 - Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy)propylamine - Google Patents
Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy)propylamineInfo
- Publication number
- ES2101655A1 ES2101655A1 ES09501530A ES9501530A ES2101655A1 ES 2101655 A1 ES2101655 A1 ES 2101655A1 ES 09501530 A ES09501530 A ES 09501530A ES 9501530 A ES9501530 A ES 9501530A ES 2101655 A1 ES2101655 A1 ES 2101655A1
- Authority
- ES
- Spain
- Prior art keywords
- trifluoromethylphenoxy
- phenyl
- converting
- reaction
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy)propylamine Consists of the following stages: Reacting benzaldehyde with allylmagnesium bromide to obtain 1-phenyl-3-buten-1- ol, converting this into 4-phenol-4-(p- trifluoromethylphenoxy) butene by reaction with 4- trifluoromethylphenol in the presence of triphenyl phosphine and diethyl azodicarboxylate, converting the product obtained into 3-phenyl-3-(p- trifluoromethylphenoxy) propanal by reaction with osmium tetroxide and sodium periodate, converting the product obtained into title product I by reaction with methylamine under conditions for the formation of the corresponding imine, and subsequent in situ reduction of the imine formed using sodium cyanoborohydride. Finally product I is converted into its hydrochloride by the addition of hydrogen chloride. The invention is of use in the advantageous industrial preparation of I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501530A ES2101655B1 (en) | 1995-07-28 | 1995-07-28 | N-METHYL-3-PHENYL-3- (P-TRIFLUOROMETILFE NOXI) PROPYLAMINE PREPARATION PROCEDURE. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501530A ES2101655B1 (en) | 1995-07-28 | 1995-07-28 | N-METHYL-3-PHENYL-3- (P-TRIFLUOROMETILFE NOXI) PROPYLAMINE PREPARATION PROCEDURE. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2101655A1 true ES2101655A1 (en) | 1997-07-01 |
ES2101655B1 ES2101655B1 (en) | 1998-01-16 |
Family
ID=8291207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9501530A Expired - Fee Related ES2101655B1 (en) | 1995-07-28 | 1995-07-28 | N-METHYL-3-PHENYL-3- (P-TRIFLUOROMETILFE NOXI) PROPYLAMINE PREPARATION PROCEDURE. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2101655B1 (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES433720A1 (en) * | 1974-01-10 | 1976-12-01 | Lilly Co Eli | Arloxyphenylpropylamines |
ES8707175A1 (en) * | 1986-06-13 | 1987-07-16 | Inke Sa | N-Methyl tri:fluoro:methyl-phenoxy phenyl-propylamine prepn. |
EP0369685A2 (en) * | 1988-11-14 | 1990-05-23 | Eli Lilly And Company | Fluoxetine analog |
EP0380924A1 (en) * | 1989-01-10 | 1990-08-08 | Grato Magnone | Process for the preparation of fluoxetine hydrochloride |
EP0391070A1 (en) * | 1989-03-03 | 1990-10-10 | Orion-Yhtymä Oy Fermion | Process for the preparation of N-methyl-3-(p-trifluoro-methylphenoxy)-3-phenyl-propylamine and their salts |
WO1994000416A1 (en) * | 1992-06-26 | 1994-01-06 | Richter Gedeon Vegyészeti Gyár Rt. | Preparation of n-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine and acid addition salts thereof |
-
1995
- 1995-07-28 ES ES9501530A patent/ES2101655B1/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES433720A1 (en) * | 1974-01-10 | 1976-12-01 | Lilly Co Eli | Arloxyphenylpropylamines |
ES8707175A1 (en) * | 1986-06-13 | 1987-07-16 | Inke Sa | N-Methyl tri:fluoro:methyl-phenoxy phenyl-propylamine prepn. |
EP0369685A2 (en) * | 1988-11-14 | 1990-05-23 | Eli Lilly And Company | Fluoxetine analog |
EP0380924A1 (en) * | 1989-01-10 | 1990-08-08 | Grato Magnone | Process for the preparation of fluoxetine hydrochloride |
EP0391070A1 (en) * | 1989-03-03 | 1990-10-10 | Orion-Yhtymä Oy Fermion | Process for the preparation of N-methyl-3-(p-trifluoro-methylphenoxy)-3-phenyl-propylamine and their salts |
WO1994000416A1 (en) * | 1992-06-26 | 1994-01-06 | Richter Gedeon Vegyészeti Gyár Rt. | Preparation of n-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine and acid addition salts thereof |
Also Published As
Publication number | Publication date |
---|---|
ES2101655B1 (en) | 1998-01-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL148194A0 (en) | A method of producing a compressed product | |
MY116238A (en) | Method of producing chlorine dioxide | |
AU2003218978A1 (en) | Method for activating double metallocyanide-compounds | |
NO20001640D0 (en) | Process for preparing a chloramine solution | |
TW324004B (en) | Method of producing difluoromethane | |
ES2101655A1 (en) | Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy)propylamine | |
DK0737210T3 (en) | Process for the preparation of cationic starch | |
ES2103680A1 (en) | Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy) propylamine | |
ES1031305U (en) | Built-in dispenser pack. (Machine-translation by Google Translate, not legally binding) | |
HUP9801720A2 (en) | Novel method for making palatinitol | |
IE44046L (en) | Cyclopropanes | |
AU2542400A (en) | Method for producing l-ascorbic acid | |
MX9702198A (en) | Processes for the preparation of (e)-2-fluoromethylene-4-(4-. | |
AU4502097A (en) | Process for the production of cyanocinnamamides | |
AU2002226308A1 (en) | Method for producing dnda | |
AU4709997A (en) | Preparation of chemically reactive polysaccharides | |
IL131513A0 (en) | Method for producing 1,3-di-substituted 2-nitroguanidines | |
PL318113A1 (en) | Method of obtaining cyclic lactams | |
EP0215623A3 (en) | Production of novel heteropolysaccharides | |
GB9823980D0 (en) | A process for making n-butyl ethers of glycols | |
AU566279B2 (en) | Hydrogen peroxide production by the anthraquinone process | |
ES2103681A1 (en) | Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy)propylamine | |
DE3375477D1 (en) | Production of formaldehyde | |
AU2002227970A1 (en) | Method for producing cis-2-tert-butylcyclohexanol | |
NO991189L (en) | Process for the preparation of N-phosphonomethylglycine and its salts |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19970701 Kind code of ref document: A1 Effective date: 19970701 |
|
FD1A | Patent lapsed |
Effective date: 20060729 |