ES2101342T3 - TETRAZOLE DERIVATIVES SUBSTITUTED WITH PHOSPHONE. - Google Patents
TETRAZOLE DERIVATIVES SUBSTITUTED WITH PHOSPHONE.Info
- Publication number
- ES2101342T3 ES2101342T3 ES93920310T ES93920310T ES2101342T3 ES 2101342 T3 ES2101342 T3 ES 2101342T3 ES 93920310 T ES93920310 T ES 93920310T ES 93920310 T ES93920310 T ES 93920310T ES 2101342 T3 ES2101342 T3 ES 2101342T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- carboxyl
- formula
- aryl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/14—Use of materials for tobacco smoke filters of organic materials as additive
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/16—Use of materials for tobacco smoke filters of inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F2/00—Monocomponent artificial filaments or the like of cellulose or cellulose derivatives; Manufacture thereof
- D01F2/24—Monocomponent artificial filaments or the like of cellulose or cellulose derivatives; Manufacture thereof from cellulose derivatives
- D01F2/28—Monocomponent artificial filaments or the like of cellulose or cellulose derivatives; Manufacture thereof from cellulose derivatives from organic cellulose esters or ethers, e.g. cellulose acetate
Abstract
The present invention relates to the N-phosphonomethyl substituted tetrazole derivatives of formula (I) and tautomers thereof wherein R0 represents (i) a group of formula (Ia) or (ii) a group of formula -X-COR3 (Ib); R and R' represent independently hydrogen, carbocyclic aryl, 6-tetrahydronaphthyl, 5-indanyl, (alpha)-(trichloromethyl, carboxyl, esterified carboxyl or amidated carboxyl) substituted-(lower alkyl or aryl-lower alkyl), acyloxymethyl optionally monosubstituted on methyl carbon by lower alkyl, by C5-C7-cycloalkyl, by aryl or by aryl-lower alkyl; R1 represents phenyl, or phenyl substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl; or R1 represents thienyl or furanyl optionally substituted by lower alkyl; or R1 represents hydrogen, if R0 represents a group of formula (Ia); R2 and R4 represent hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen or trifluoromethyl; n is 0, 1 or 2; COR3 carboxyl or carboxyl derivatized in form of a pharmaceutically acceptable ester; X represents a direct bond, C1-4-alkylene or C2-4-alkenylene; and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; methods for preparation of said compounds and for the preparation of intermediates; and methods of treating disorders in mammals which are responsive to the inhibition of neutral endopeptidases by administration of said compounds to mammals in need of such treatment.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/940,118 US5273990A (en) | 1992-09-03 | 1992-09-03 | Phosphono substituted tetrazole derivatives |
US07/959,000 US5250522A (en) | 1992-10-09 | 1992-10-09 | Phosphono/biaryl substituted amino acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2101342T3 true ES2101342T3 (en) | 1997-07-01 |
Family
ID=27130130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93920310T Expired - Lifetime ES2101342T3 (en) | 1992-09-03 | 1993-08-24 | TETRAZOLE DERIVATIVES SUBSTITUTED WITH PHOSPHONE. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0660840B1 (en) |
JP (1) | JP3130938B2 (en) |
KR (1) | KR950702996A (en) |
AT (1) | ATE152727T1 (en) |
AU (1) | AU5089693A (en) |
CA (1) | CA2142348A1 (en) |
DE (1) | DE69310524T2 (en) |
DK (1) | DK0660840T3 (en) |
ES (1) | ES2101342T3 (en) |
FI (1) | FI950925A (en) |
GR (1) | GR3024314T3 (en) |
HU (1) | HUT72615A (en) |
IL (1) | IL106810A0 (en) |
NO (1) | NO950827L (en) |
NZ (1) | NZ255878A (en) |
WO (1) | WO1994005677A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583123A (en) * | 1994-12-22 | 1996-12-10 | Ciba-Geigy Corporation | Certain tetrazole derivatives |
US5550119A (en) * | 1995-03-02 | 1996-08-27 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives as ECE inhibitors |
US8673974B2 (en) * | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD141930A1 (en) * | 1979-02-20 | 1980-05-28 | Kurt Issleib | PROCESS FOR THE PREPARATION OF N-PHOSPHONOMETHYLAMINOSAURES AND THEIR ESTERS |
US5155100A (en) * | 1991-05-01 | 1992-10-13 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipeptide derivatives |
-
1992
- 1992-10-16 JP JP05507272A patent/JP3130938B2/en not_active Expired - Lifetime
-
1993
- 1993-08-24 ES ES93920310T patent/ES2101342T3/en not_active Expired - Lifetime
- 1993-08-24 EP EP93920310A patent/EP0660840B1/en not_active Expired - Lifetime
- 1993-08-24 NZ NZ255878A patent/NZ255878A/en unknown
- 1993-08-24 AU AU50896/93A patent/AU5089693A/en not_active Abandoned
- 1993-08-24 WO PCT/US1993/007965 patent/WO1994005677A1/en active IP Right Grant
- 1993-08-24 KR KR1019950700824A patent/KR950702996A/en not_active Application Discontinuation
- 1993-08-24 HU HU9500648A patent/HUT72615A/en unknown
- 1993-08-24 AT AT93920310T patent/ATE152727T1/en not_active IP Right Cessation
- 1993-08-24 DK DK93920310.5T patent/DK0660840T3/en active
- 1993-08-24 DE DE69310524T patent/DE69310524T2/en not_active Expired - Fee Related
- 1993-08-24 CA CA002142348A patent/CA2142348A1/en not_active Abandoned
- 1993-08-26 IL IL106810A patent/IL106810A0/en unknown
-
1995
- 1995-03-01 FI FI950925A patent/FI950925A/en not_active Application Discontinuation
- 1995-03-02 NO NO950827A patent/NO950827L/en unknown
-
1997
- 1997-07-30 GR GR970401963T patent/GR3024314T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR950702996A (en) | 1995-08-23 |
EP0660840A1 (en) | 1995-07-05 |
FI950925A0 (en) | 1995-03-01 |
ATE152727T1 (en) | 1997-05-15 |
IL106810A0 (en) | 1993-12-08 |
NO950827L (en) | 1995-06-09 |
AU5089693A (en) | 1994-03-29 |
WO1994005677A1 (en) | 1994-03-17 |
JP3130938B2 (en) | 2001-01-31 |
JPH08501098A (en) | 1996-02-06 |
NZ255878A (en) | 1996-12-20 |
CA2142348A1 (en) | 1994-03-17 |
FI950925A (en) | 1995-03-01 |
HUT72615A (en) | 1996-05-28 |
DK0660840T3 (en) | 1997-07-14 |
DE69310524T2 (en) | 1997-12-04 |
EP0660840B1 (en) | 1997-05-07 |
GR3024314T3 (en) | 1997-10-31 |
DE69310524D1 (en) | 1997-06-12 |
NO950827D0 (en) | 1995-03-02 |
HU9500648D0 (en) | 1995-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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