ES2100397T3 - Espiro(5.5)undecanos 3,9-disubstituidos activos sobre el sistema cardiovascular, proceso para su preparacion y composicion farmaceutica que contiene los mismos. - Google Patents
Espiro(5.5)undecanos 3,9-disubstituidos activos sobre el sistema cardiovascular, proceso para su preparacion y composicion farmaceutica que contiene los mismos.Info
- Publication number
- ES2100397T3 ES2100397T3 ES93110193T ES93110193T ES2100397T3 ES 2100397 T3 ES2100397 T3 ES 2100397T3 ES 93110193 T ES93110193 T ES 93110193T ES 93110193 T ES93110193 T ES 93110193T ES 2100397 T3 ES2100397 T3 ES 2100397T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- opt
- substd
- undecans
- espiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/28—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/36—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/50—Spiro compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
Abstract
3,9-SPIRO[5.5] UNDECANOS DISUSTITUIDOS DE FORMULA (I): EN LA QUE R REPRESENTA HIDROGENO O UN GRUPO ALKILO C2-C6 O ALKENILO C2-C6 SUSTITUIDO O INSUSTITUIDO, N ES UN NUMERO ENTERO DE 0 A 4 E Y ES OXIGENO O AZUFRE; Y EL SIMBOLO--CE SENCILLO O DOBLE SI (I) CUANDO -REPRESENTA UN GRUPO C-H O C-OR1 DONDE R1 ES H O CH3, Y B REPRESENTA UN A CADENA ALKILO INFERIO C2-C6 SUSTITUIDO O AKENILO C2-C6; (II) CUANDO -DE CARBONO C Y B REPRESENTA: A = GRUPO N-NR2-C(=Z)NHR3, DONDE R2 Y R3 SON HIDROGENO, ALKILO INFERIOR C1-C6, BENCILO O FENILO, O R2 Y R3, TOMADOS JUNTOS CON LOS ATOMOS DE NITROGENO, FORMAN UN ANILLO DE 5 O 5 MIEMBROS, Y Z ES OXIGENO, AZUFRE O NR9, DONDE R9 ES H,ALKILO INFERIOR C1-C4, CN O TOMADO JUNTO CON R2 O R3 FORMA UN ANILLO DE 5 O 6 MIEMBROS MONOHETEROCICLICO SUSTITUIDO; Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPUESTOS PUEDEN SER USADOS PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE TRASTORNOS CARDIOVASCULARES, HIPERTENSION Y/O FALLO CARDIACO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4222459A DE4222459C2 (de) | 1992-07-08 | 1992-07-08 | 3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2100397T3 true ES2100397T3 (es) | 1997-06-16 |
Family
ID=6462775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93110193T Expired - Lifetime ES2100397T3 (es) | 1992-07-08 | 1993-06-25 | Espiro(5.5)undecanos 3,9-disubstituidos activos sobre el sistema cardiovascular, proceso para su preparacion y composicion farmaceutica que contiene los mismos. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5444082A (es) |
EP (1) | EP0578080B1 (es) |
JP (1) | JPH06239785A (es) |
AT (1) | ATE152107T1 (es) |
DE (2) | DE4222459C2 (es) |
DK (1) | DK0578080T3 (es) |
ES (1) | ES2100397T3 (es) |
GR (1) | GR3023595T3 (es) |
HK (1) | HK1005869A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2870538B1 (fr) * | 2004-05-19 | 2006-07-14 | Servier Lab | Nouveaux derives de pyrrolidines et de thiazolidines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
SG11202004019SA (en) | 2017-11-17 | 2020-05-28 | Cellix Bio Private Ltd | Compositions and methods for the treatment of eye disorders |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3256277A (en) * | 1966-06-14 | Azaspiro alkanes | ||
BE788490A (fr) * | 1971-09-08 | 1973-01-02 | Geschickter Fund Med Res | Azaspiranes substitues par du silicium ou du germanium, leur preparation et compositions pharmaceutiques les contenant |
US4098823A (en) * | 1976-02-11 | 1978-07-04 | Miles Laboratories, Inc. | Monospiroalkyl derivatives of prostaglandins |
US4737503A (en) * | 1986-10-08 | 1988-04-12 | Vipont Laboratories, Inc. | Method for inhibiting the release of histamine |
US4963557A (en) * | 1987-09-28 | 1990-10-16 | Smithkline Beecham Corporation | Immunomodulatory azaspiranes |
US5234922A (en) * | 1992-09-28 | 1993-08-10 | University Of Iowa Research Foundation | Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea |
-
1992
- 1992-07-08 DE DE4222459A patent/DE4222459C2/de not_active Expired - Fee Related
-
1993
- 1993-06-25 AT AT93110193T patent/ATE152107T1/de not_active IP Right Cessation
- 1993-06-25 ES ES93110193T patent/ES2100397T3/es not_active Expired - Lifetime
- 1993-06-25 EP EP93110193A patent/EP0578080B1/en not_active Expired - Lifetime
- 1993-06-25 DE DE59306238T patent/DE59306238D1/de not_active Expired - Fee Related
- 1993-06-25 DK DK93110193.5T patent/DK0578080T3/da active
- 1993-06-28 US US08/082,372 patent/US5444082A/en not_active Expired - Fee Related
- 1993-07-08 JP JP5168890A patent/JPH06239785A/ja active Pending
-
1997
- 1997-05-30 GR GR970401238T patent/GR3023595T3/el unknown
-
1998
- 1998-06-05 HK HK98104926A patent/HK1005869A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0578080B1 (en) | 1997-04-23 |
DE4222459A1 (de) | 1994-01-13 |
DK0578080T3 (da) | 1997-07-21 |
GR3023595T3 (en) | 1997-08-29 |
DE59306238D1 (de) | 1997-05-28 |
EP0578080A3 (es) | 1994-04-13 |
US5444082A (en) | 1995-08-22 |
JPH06239785A (ja) | 1994-08-30 |
HK1005869A1 (en) | 1999-01-29 |
EP0578080A2 (en) | 1994-01-12 |
ATE152107T1 (de) | 1997-05-15 |
DE4222459C2 (de) | 1995-09-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE204269T1 (de) | Substituierte biphenyl- oder phenylpyridinderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen | |
MX9303441A (es) | Procedimiento para la preparacion de acido clavulanico. | |
MX9206847A (es) | Derivados de indolpirrolcarbazol, proceso para su preparacion y medicamento que los contiene | |
ES2096685T3 (es) | Composicion que contiene colorantes del tipo rodacianina para el tratamiento del cancer. | |
DE58901510D1 (de) | 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel. | |
ATE9464T1 (de) | Neue carbonsaeureamide, ihre herstellung und ihre verwendung als arzneimittel. | |
DE3177205D1 (de) | Industrielle verbindungen anwendbar als zwischenprodukte in der herstellung von in stellung 2 substituierten 4-hydroxy 3-quinolincarboxamid-derivaten und die herstellung von diesen zwischenprodukten. | |
ES2100397T3 (es) | Espiro(5.5)undecanos 3,9-disubstituidos activos sobre el sistema cardiovascular, proceso para su preparacion y composicion farmaceutica que contiene los mismos. | |
PT96788A (pt) | Processo de preparacao de compostos de ureia substituida e de composicoes farmaceuticas | |
ES2031894T3 (es) | Procedimiento para preparar derivados de 4(3h)-oxo-5,6,7,8-tetrahidropirido-(2,3-d)-pirimidina. | |
ES2056811T3 (es) | Derivados de cinolina, procedimiento para su preparacion y composiciones herbicidas que los contienen. | |
ES8604861A1 (es) | Procedimiento para la preparacion de derivados de fenilace- tonitrilo | |
ES365335A1 (es) | Procedimiento para preparar amimocetonas aromaticas. | |
ES8503652A1 (es) | Un procedimiento para la preparacion de un compuesto. | |
IL89682A0 (en) | 5,7-dihydropyrrolo(3,2-f)-benzoxazol-6-ones,processes for the preparation thereof and pharmaceutical compositions containing them | |
GB1348258A (en) | 9-oxo-6.9-dihydro-4h-dioxino-4,5-g-quinolyl-8-carboxylic acids and their isomers, 10-oxo-7,10-dihydro-1h-dioxino-5,4-f-quinolyl- 9-carboxylic acids | |
FR2374905A2 (fr) | Derives de naphtyridine | |
FR2358146A1 (fr) | Derives de la tetrahydro-1,2,3,3a indolo(3,2,1-de) (1,5)naphtyridine | |
NZ184816A (en) | Substituted 2,3-alkylene-bis-(oxy)-benzamides and pharmaceutical compositions intermediate acids | |
FR2383182A2 (fr) | Nouveaux derives de naphtyridine | |
ES428535A1 (es) | Un procedimiento para la preparacion de cicloserina n-sus- tituida. | |
FR2368955A2 (fr) | Derives de la tetrahydro-1,2,3,3a indolo (3,2,1-de) (1,5) naphtyridine | |
GB1353513A (en) | Streptozotocin derivatives | |
BR8306505A (pt) | Compostos,processo para preparacao dos mesmos,medicamento e uso de tais compostos | |
GB1109470A (en) | New oxazolinones |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 578080 Country of ref document: ES |