ES2096203T3 - Nuevos derivados de fisostigmina, su uso y formulaciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de fisostigmina, su uso y formulaciones farmaceuticas que los contienen.

Info

Publication number
ES2096203T3
ES2096203T3 ES93301955T ES93301955T ES2096203T3 ES 2096203 T3 ES2096203 T3 ES 2096203T3 ES 93301955 T ES93301955 T ES 93301955T ES 93301955 T ES93301955 T ES 93301955T ES 2096203 T3 ES2096203 T3 ES 2096203T3
Authority
ES
Spain
Prior art keywords
physostigmine
contain
pharmaceutical formulations
new salts
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93301955T
Other languages
English (en)
Inventor
Ezio Bombardelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Application granted granted Critical
Publication of ES2096203T3 publication Critical patent/ES2096203T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE EL USO TERAPEUTICO DE NUEVAS SALES DE LA FISOSTIGMINA EN EL TRATAMIENTO DE LOS SINDROMES RELACIONADOS CON LOS CAMBIOS EN EL METABOLISMO CEREBRAL. LAS NUEVAS SALES DE FISOSTIGMINA QUE SE BASAN EN EL ACIDO FOSFATIDICO, SON ALTAMENTE LIPOFILICAS Y EXHIBEN UNA EXCELENTE BIOCAPACIDAD CUANDO SE ADMINISTRAN ORALMENTE, DE FORMA TRANSCUTANEA O TRANSEPIDERMALMENTE. LAS NUEVAS SALES SON PARTICULARMENTE VALIOSAS CUANDO SE INCORPORAN EN GELES O FORMAS FARMACEUTICAS ADECUADAS PARA EL TRATAMIENTO SENIL Y LA ENFERMEDAD DE ALZHEIMER.
ES93301955T 1992-03-16 1993-03-15 Nuevos derivados de fisostigmina, su uso y formulaciones farmaceuticas que los contienen. Expired - Lifetime ES2096203T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929205670A GB9205670D0 (en) 1992-03-16 1992-03-16 New derivatives of physostigmine,their use and pharmaceutical formulations containing them

Publications (1)

Publication Number Publication Date
ES2096203T3 true ES2096203T3 (es) 1997-03-01

Family

ID=10712207

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93301955T Expired - Lifetime ES2096203T3 (es) 1992-03-16 1993-03-15 Nuevos derivados de fisostigmina, su uso y formulaciones farmaceuticas que los contienen.

Country Status (13)

Country Link
US (1) US5314906A (es)
EP (1) EP0561597B1 (es)
JP (1) JPH0640914A (es)
KR (1) KR100251395B1 (es)
AT (1) ATE147076T1 (es)
CA (1) CA2091550A1 (es)
DE (1) DE69306990T2 (es)
DK (1) DK0561597T3 (es)
ES (1) ES2096203T3 (es)
GB (1) GB9205670D0 (es)
GR (1) GR3022205T3 (es)
HK (1) HK61897A (es)
SG (1) SG67287A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861431A (en) * 1995-06-07 1999-01-19 Iotek, Inc. Incontinence treatment
US5709878A (en) * 1996-08-02 1998-01-20 Rosenbaum; Jerry Transdermal delivery of dehydroepiandrosterone
IL121322A (en) * 1997-07-16 2002-07-25 Modus Biolog Membranes Ltd Modular pharmacological preparation of the immune system based on fats and its preparation
WO1999007355A1 (fr) * 1997-08-12 1999-02-18 Takeda Chemical Industries, Ltd. Preparation contenant de l'idebenone pour administration par voie percutanee
US5869090A (en) * 1998-01-20 1999-02-09 Rosenbaum; Jerry Transdermal delivery of dehydroepiandrosterone
DE10025644A1 (de) * 2000-05-24 2001-12-06 Lohmann Therapie Syst Lts Schmales bandförmiges transdermales therapeutisches System zur Applikation von Wirkstoffen direkt über dem arteriellen oder venösen Gefäßsystem
CA2458068A1 (en) * 2001-08-20 2003-02-27 Tatton Technologies, Llc. Methods and compositions for treating apoptosis associated disorders
KR100758089B1 (ko) * 2005-08-04 2007-09-11 아이알 마이크로시스템 에스.에이. 기체 검출 방법 및 기체 검출 장치

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1109003B (it) * 1977-09-20 1985-12-16 Univ Firenze Derivati dell 1 2 3 8 3 a 8 a esai dropirrolo 23 b indolo
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
IT1225462B (it) * 1987-04-03 1990-11-14 Mediolanum Farmaceutici Srl Sali organici di derivati della fisostigmina
EP0350672A1 (en) * 1988-06-28 1990-01-17 MAGIS FARMACEUTICI S.p.A. Salts of diacyl-glycero-(di)-phosphates of L-(acyl) carnitine and of L-acyl-carnitine esters
IT1238684B (it) * 1990-02-09 1993-09-01 Indena Spa Derivati del bilobalide,loro usi e formulazioni che li contegono
EP0513703A3 (en) * 1991-05-13 1993-01-13 Magis Farmaceutici S.P.A. Carbamate esters of eseroline having anticholinesterase activity, a process for their preparation and relative pharmaceutical compositions containing them as the active principle

Also Published As

Publication number Publication date
ATE147076T1 (de) 1997-01-15
DE69306990T2 (de) 1997-06-12
KR100251395B1 (ko) 2000-05-01
EP0561597A1 (en) 1993-09-22
EP0561597B1 (en) 1997-01-02
CA2091550A1 (en) 1993-09-17
KR930019212A (ko) 1993-10-18
JPH0640914A (ja) 1994-02-15
DE69306990D1 (de) 1997-02-13
US5314906A (en) 1994-05-24
HK61897A (en) 1997-05-16
SG67287A1 (en) 1999-09-21
GR3022205T3 (en) 1997-04-30
DK0561597T3 (da) 1997-01-20
GB9205670D0 (en) 1992-04-29

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