ES2095266T3 - DERIVATIVES OF BENZIMIDAZOLE, ITS PRODUCTION AND USE. - Google Patents
DERIVATIVES OF BENZIMIDAZOLE, ITS PRODUCTION AND USE.Info
- Publication number
- ES2095266T3 ES2095266T3 ES91106330T ES91106330T ES2095266T3 ES 2095266 T3 ES2095266 T3 ES 2095266T3 ES 91106330 T ES91106330 T ES 91106330T ES 91106330 T ES91106330 T ES 91106330T ES 2095266 T3 ES2095266 T3 ES 2095266T3
- Authority
- ES
- Spain
- Prior art keywords
- benzimidazole
- anion
- substd
- opt
- tetrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Benzimidazole derivs. of formula (I) and their salts are new. In (I) A = a benzene ring opt. substd. in addn. to R1; R1 = H or opt. substd. hydrocarbon gp.; R2 = a gp. capable of forming an anion or convertible into an anion; X = a direct bond or a spacer 1-2 atoms long between the phenylene and phenyl gp.; R' = carboxyl, its esters or amides, or a gp. capable of forming an anion or convertible to an anion; Y = -O-, -S(O)m- or -N(R4)-, (where m = 0, 1 or 2 and R4 = H or opt. substd. alkyl); and n = 1 or 2. 33 cpds. are specifically claimed including ethyl-2-ethoxy-1-((2'- (1H-tetrazol-5-yl)biphenyl-4-yl)methyl) benzimidazole-7-carboxylate. Also claimed is a stable crystal of 1-(cyclohexyloxycarbonyloxy) ethyl-2-ethoxy-1-((2'-(1H tetrazol-5-yl) -biphenyl-4-yl)-methyl)benzimidazole -7-carboxylate.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11314890 | 1990-04-27 | ||
JP14194290 | 1990-05-30 | ||
JP20866290 | 1990-08-06 | ||
JP26457990 | 1990-10-01 | ||
JP41367990 | 1990-12-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2095266T3 true ES2095266T3 (en) | 1997-02-16 |
Family
ID=27526589
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95118796T Expired - Lifetime ES2181742T3 (en) | 1990-04-27 | 1991-04-19 | DERIVATIVES OF BENZOIMIDAZOL, ITS PRODUCTION AND USE AS ANTAGONISTS OF ANGIOTENSIN II. |
ES91106330T Expired - Lifetime ES2095266T3 (en) | 1990-04-27 | 1991-04-19 | DERIVATIVES OF BENZIMIDAZOLE, ITS PRODUCTION AND USE. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95118796T Expired - Lifetime ES2181742T3 (en) | 1990-04-27 | 1991-04-19 | DERIVATIVES OF BENZOIMIDAZOL, ITS PRODUCTION AND USE AS ANTAGONISTS OF ANGIOTENSIN II. |
Country Status (22)
Country | Link |
---|---|
US (4) | US5196444A (en) |
EP (2) | EP0459136B1 (en) |
JP (2) | JP2514282B2 (en) |
KR (1) | KR100200541B1 (en) |
CN (2) | CN1048486C (en) |
AT (2) | ATE227709T1 (en) |
CA (2) | CA2040955C (en) |
CY (1) | CY2150B1 (en) |
DE (3) | DE19875004I2 (en) |
DK (2) | DK0720982T3 (en) |
ES (2) | ES2181742T3 (en) |
FI (2) | FI108434B (en) |
GR (1) | GR3022172T3 (en) |
HK (1) | HK1000803A1 (en) |
HU (2) | HU213266B (en) |
IE (1) | IE911317A1 (en) |
LU (1) | LU90224I2 (en) |
LV (1) | LV10258B (en) |
NL (1) | NL970044I2 (en) |
NO (3) | NO300923B1 (en) |
NZ (1) | NZ237949A (en) |
PT (1) | PT97451B (en) |
Families Citing this family (226)
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1996
- 1996-05-23 CN CN96107765A patent/CN1058966C/en not_active Expired - Lifetime
- 1996-12-30 GR GR960403557T patent/GR3022172T3/en unknown
-
1997
- 1997-01-16 NO NO970195A patent/NO302752B1/en not_active IP Right Cessation
- 1997-12-13 HK HK97102420A patent/HK1000803A1/en not_active IP Right Cessation
- 1997-12-19 NL NL970044C patent/NL970044I2/en unknown
-
1998
- 1998-03-11 LU LU90224C patent/LU90224I2/en unknown
- 1998-06-17 NO NO1998018C patent/NO1998018I1/en unknown
- 1998-10-21 CY CY9800044A patent/CY2150B1/en unknown
- 1998-12-21 FI FI982761A patent/FI114983B/en active IP Right Grant
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