ES2093108T3 - Complejos de oxido nitrico y de poliamidas. - Google Patents

Complejos de oxido nitrico y de poliamidas.

Info

Publication number
ES2093108T3
ES2093108T3 ES91917752T ES91917752T ES2093108T3 ES 2093108 T3 ES2093108 T3 ES 2093108T3 ES 91917752 T ES91917752 T ES 91917752T ES 91917752 T ES91917752 T ES 91917752T ES 2093108 T3 ES2093108 T3 ES 2093108T3
Authority
ES
Spain
Prior art keywords
nitric oxide
complexes
polyamides
disclosed
endothelium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91917752T
Other languages
English (en)
Inventor
Larry Kay Keefer
Joseph Anthony Hrabie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Commerce
Original Assignee
US Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Commerce filed Critical US Department of Commerce
Application granted granted Critical
Publication of ES2093108T3 publication Critical patent/ES2093108T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/04—N-nitroso compounds
    • C07C243/06—N-nitroso-amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B21/00—Nitrogen; Compounds thereof
    • C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
    • C01B21/24—Nitric oxide (NO)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PRESENTAN NUEVOS COMPLEJOS DE OXIDO NITRICO Y POLIAMINAS QUE SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS CARDIOVASCULARES, INCLUIDA LA HIPERTENSION. LOS COMPUESTOS PRESENTADOS LIBERAN OXIDO NITRICO (FACTOR RELAJANTE DERIVADO DEL ENDOTELIO) BAJO CONDICIONES FISIOLOGICAS DE MANERA SOSTENIDA Y CONTROLABLE Y POSEEN AMPLIOS MECANISMOS DE ACCION.
ES91917752T 1990-09-20 1991-09-20 Complejos de oxido nitrico y de poliamidas. Expired - Lifetime ES2093108T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/585,793 US5155137A (en) 1990-09-20 1990-09-20 Complexes of nitric oxide with polyamines

Publications (1)

Publication Number Publication Date
ES2093108T3 true ES2093108T3 (es) 1996-12-16

Family

ID=24342988

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91917752T Expired - Lifetime ES2093108T3 (es) 1990-09-20 1991-09-20 Complejos de oxido nitrico y de poliamidas.

Country Status (9)

Country Link
US (2) US5155137A (es)
EP (1) EP0549704B1 (es)
JP (1) JP2537445B2 (es)
AT (1) ATE140446T1 (es)
AU (1) AU649739B2 (es)
CA (1) CA2091994C (es)
DE (1) DE69120955T2 (es)
ES (1) ES2093108T3 (es)
WO (1) WO1992005149A1 (es)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
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DE69120955D1 (de) 1996-08-22
US5155137A (en) 1992-10-13
DE69120955T2 (de) 1996-11-21
EP0549704A4 (en) 1994-04-27
CA2091994C (en) 2000-01-25
ATE140446T1 (de) 1996-08-15
EP0549704B1 (en) 1996-07-17
EP0549704A1 (en) 1993-07-07
JPH06501686A (ja) 1994-02-24
AU649739B2 (en) 1994-06-02
JP2537445B2 (ja) 1996-09-25
US5250550A (en) 1993-10-05
AU8712391A (en) 1992-04-15
CA2091994A1 (en) 1992-03-21
WO1992005149A1 (en) 1992-04-02

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