ES2091095T3 - Nuevo procedimiento de preparacion de esteroides 16alfa-metilados. - Google Patents
Nuevo procedimiento de preparacion de esteroides 16alfa-metilados.Info
- Publication number
- ES2091095T3 ES2091095T3 ES94400114T ES94400114T ES2091095T3 ES 2091095 T3 ES2091095 T3 ES 2091095T3 ES 94400114 T ES94400114 T ES 94400114T ES 94400114 T ES94400114 T ES 94400114T ES 2091095 T3 ES2091095 T3 ES 2091095T3
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- hydrogen
- beta
- optionally
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCEDIMIENTO NUEVO DE PREPARACION DE COMPUESTOS DE FORMULA (I), EN LA QUE LOS CICLOS A Y B REPRESENTAN 3 CETO * 4 6 IDA EN 3, O 3 ES HIDROGENO O UN RESIDUO ETER O ESTER, R1 Y R2 FORMAN UN EPOXIDO EN BETA, UN SEGUNDO ENLACE, O R1 ES HIDROGENO, CETONA, O HIDROXI EN ALFA O BETA, EVENTUALMENTE EN FORMA ETERIFICADA O ESTERIFICADA, Y R2 ES HIDROGENO, O R1 ES HIDROGENO Y R2 ES ALFA-HIDROXI, O R1 ES BETA-HIDROXI EVENTUALMENTE ESTERIFICADO O ESTERIFICADO Y R2 ES UN FLUOR O UN BROMO EN ALFA, R3 ES HIDROGENO, FLUOR O METILO EN ALFA O BETA, SEGUN LO CUAL SE TRATA UN DERIVADO * 16(17) POR UN AGENTE DE METILACION, DESPUES HIDROLIZA EL ENOLATO 16ALFA TOS (I) SON ANTIINFLAMATORIOS CONOCIDOS O PRECURSORES POSIBLES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9300519A FR2700548B1 (fr) | 1993-01-20 | 1993-01-20 | Nouveau procédé de préparation de stéroïdes 16 alpha-méthylés. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2091095T3 true ES2091095T3 (es) | 1996-10-16 |
Family
ID=9443202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94400114T Expired - Lifetime ES2091095T3 (es) | 1993-01-20 | 1994-01-19 | Nuevo procedimiento de preparacion de esteroides 16alfa-metilados. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5508452A (es) |
EP (1) | EP0608178B1 (es) |
JP (1) | JP3535555B2 (es) |
KR (1) | KR100284824B1 (es) |
CN (1) | CN1040647C (es) |
AT (1) | ATE140924T1 (es) |
AU (1) | AU667147B2 (es) |
CA (1) | CA2113776C (es) |
DE (1) | DE69400340T2 (es) |
DK (1) | DK0608178T3 (es) |
ES (1) | ES2091095T3 (es) |
FR (1) | FR2700548B1 (es) |
GR (1) | GR3020751T3 (es) |
HU (1) | HU221320B1 (es) |
RU (1) | RU2127278C1 (es) |
UA (1) | UA44887C2 (es) |
ZA (1) | ZA94405B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6040468A (en) * | 1996-10-25 | 2000-03-21 | Alcon Laboratories, Inc. | Method of preparing 16α, 17α-dialkylated steroids |
US6841665B2 (en) | 2000-02-18 | 2005-01-11 | The University Of Hong Kong | Method for synthesizing 5β, 6β-epoxides of steroids by a highly β-selective epoxidation of ΔΔ5-unsaturated steroids catalyzed by ketones |
HUE046243T2 (hu) | 2008-05-28 | 2020-02-28 | Reveragen Biopharma Inc | Nem-hormonális NF-KB szteroid modulátorok betegség kezelésére |
EP2556083A4 (en) | 2010-04-05 | 2013-12-04 | Validus Biopharma Inc | NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT |
WO2017004205A1 (en) | 2015-06-29 | 2017-01-05 | Reveragen Biopharma, Inc. | NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE |
US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
CN115322242B (zh) * | 2022-09-14 | 2023-09-12 | 山东赛托生物科技股份有限公司 | 一种高品质甾体药物中间体的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE28369E (en) * | 1957-02-27 | 1975-03-18 | Atcc-zxs | |
US3080393A (en) * | 1960-02-04 | 1963-03-05 | Syntex Corp | Process for preparing 16alpha-methyl-17alpha-hydroxy-20-keto-pregnanes from the corresponding 16-dehydro-20-keto pregnanes |
JPS504657B1 (es) * | 1968-07-30 | 1975-02-22 | ||
US4022769A (en) * | 1974-05-13 | 1977-05-10 | Richardson-Merrell Inc. | Androst-4-en-19-ones |
NL7607283A (nl) * | 1975-07-23 | 1977-01-25 | Merck & Co Inc | Werkwijze voor het bereiden van nieuwe pregnaansteroiden. |
US4990612A (en) * | 1984-06-11 | 1991-02-05 | The Upjohn Company | 16α-methylation process |
US4704455A (en) * | 1984-06-11 | 1987-11-03 | The Upjohn Company | 16α-methylatedΔ17(20)-corticoids |
JPS611699A (ja) * | 1984-06-11 | 1986-01-07 | ジ アツプジヨン カンパニー | 16α‐メチル化法 |
HU203768B (en) * | 1986-06-04 | 1991-09-30 | Upjohn Co | New metilating process for producing 16-alpha-methyl-steroides |
US4772755A (en) * | 1987-03-19 | 1988-09-20 | Mcneilab, Inc. | 1,2-1,4 addition reaction sequence leading to disubstituted acelylenes |
FR2643638B1 (fr) * | 1989-02-24 | 1991-06-14 | Roussel Uclaf | Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
FR2692266B1 (fr) * | 1992-06-11 | 1994-08-05 | Roussel Uclaf | Nouveau procede de preparation de sterouides 16 alpha-methyles. |
-
1993
- 1993-01-20 FR FR9300519A patent/FR2700548B1/fr not_active Expired - Fee Related
-
1994
- 1994-01-12 US US08/180,454 patent/US5508452A/en not_active Expired - Lifetime
- 1994-01-19 UA UA94005065A patent/UA44887C2/uk unknown
- 1994-01-19 DK DK94400114.8T patent/DK0608178T3/da active
- 1994-01-19 EP EP94400114A patent/EP0608178B1/fr not_active Expired - Lifetime
- 1994-01-19 JP JP01776294A patent/JP3535555B2/ja not_active Expired - Lifetime
- 1994-01-19 ES ES94400114T patent/ES2091095T3/es not_active Expired - Lifetime
- 1994-01-19 AT AT94400114T patent/ATE140924T1/de active
- 1994-01-19 DE DE69400340T patent/DE69400340T2/de not_active Expired - Lifetime
- 1994-01-19 KR KR1019940000937A patent/KR100284824B1/ko not_active IP Right Cessation
- 1994-01-19 RU RU94001576A patent/RU2127278C1/ru active
- 1994-01-19 CN CN94101077A patent/CN1040647C/zh not_active Expired - Lifetime
- 1994-01-19 HU HU9400156A patent/HU221320B1/hu unknown
- 1994-01-19 AU AU53847/94A patent/AU667147B2/en not_active Expired
- 1994-01-19 CA CA002113776A patent/CA2113776C/fr not_active Expired - Lifetime
- 1994-01-20 ZA ZA94405A patent/ZA94405B/xx unknown
-
1996
- 1996-08-08 GR GR960400219T patent/GR3020751T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH06293791A (ja) | 1994-10-21 |
CN1103643A (zh) | 1995-06-14 |
AU667147B2 (en) | 1996-03-07 |
EP0608178A1 (fr) | 1994-07-27 |
HU221320B1 (en) | 2002-09-28 |
HU9400156D0 (en) | 1994-05-30 |
ATE140924T1 (de) | 1996-08-15 |
GR3020751T3 (en) | 1996-11-30 |
ZA94405B (en) | 1995-01-20 |
DE69400340T2 (de) | 1997-01-23 |
UA44887C2 (uk) | 2002-03-15 |
FR2700548A1 (fr) | 1994-07-22 |
DE69400340D1 (de) | 1996-09-05 |
CA2113776C (fr) | 2004-10-05 |
US5508452A (en) | 1996-04-16 |
CA2113776A1 (fr) | 1994-07-21 |
KR940018396A (ko) | 1994-08-16 |
JP3535555B2 (ja) | 2004-06-07 |
CN1040647C (zh) | 1998-11-11 |
FR2700548B1 (fr) | 1995-03-03 |
AU5384794A (en) | 1994-07-28 |
RU2127278C1 (ru) | 1999-03-10 |
EP0608178B1 (fr) | 1996-07-31 |
DK0608178T3 (da) | 1996-10-07 |
HUT66233A (en) | 1994-10-28 |
KR100284824B1 (ko) | 2001-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2086201T3 (es) | Nuevo procedimiento de preparacion de esteroides 16-alfa-metilados. | |
MX9303139A (es) | Procedimiento para la preparacion de derivados esteroides 11-ceto. | |
ES2091095T3 (es) | Nuevo procedimiento de preparacion de esteroides 16alfa-metilados. | |
DK0610138T3 (da) | Fremgangsmåde til fremstilling af 6 alpha,9 alpha-difluorsteroider samt mellemprodukter dertil | |
RU94003400A (ru) | Метод получения 6-альфа, 9-альфа дифторированных стероидов и новые полученные производные | |
FR2700339B1 (fr) | Nouveaux dérivés 17,20-époxydes du pregnane, leur préparation, leur application à la préparation de dérivés cortisoniques et intermédiaires. | |
HUT61569A (en) | Process for producing 16-methyl- or methylenepregna-1,4-diene-3,20-dione derivatives | |
RU94001576A (ru) | Метод получения 16-альфаметилированных стероидов | |
ATE8638T1 (de) | Verfahren zur herstellung von 17-alpha-hydroxy17beta-hydroxyacetyl-steroiden und die erhaltenen entsprechenden zwischenprodukte. | |
KR930010054A (ko) | 프레그난의 20-옥소-17알파, 21-디히드록실화 유도체의 신규 제조방법 및 중간체 | |
AU8428782A (en) | 11-alpha-amino-androstane | |
ATE38235T1 (de) | Verfahren zur herstellung von 17alpha-bromethinyl- und 17alpha-jodethinyl-17beta-hydroxysteroiden und neue 17alpha-bromethinyl- und 17alphajodethinyl-17beta-hydroxysteroide. | |
ATE377605T1 (de) | 6-oxygenierte steroid-estrogene mit aromatischen a- und b-ringen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 608178 Country of ref document: ES |
|
FG2A | Definitive protection |
Ref document number: 608178 Country of ref document: ES |