ES2085833A2 - Derivados de carboximetilidencicloheptimidazol y metodo para prepararlos. - Google Patents
Derivados de carboximetilidencicloheptimidazol y metodo para prepararlos.Info
- Publication number
- ES2085833A2 ES2085833A2 ES09401628A ES9401628A ES2085833A2 ES 2085833 A2 ES2085833 A2 ES 2085833A2 ES 09401628 A ES09401628 A ES 09401628A ES 9401628 A ES9401628 A ES 9401628A ES 2085833 A2 ES2085833 A2 ES 2085833A2
- Authority
- ES
- Spain
- Prior art keywords
- carboxymethylidenecycloheptimidazole
- derivatives
- compounds
- lower alkyl
- manufacturing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IYMYPOSBCZYACX-UHFFFAOYSA-N 2-(1h-cyclohepta[d]imidazol-2-ylidene)acetic acid Chemical class C1=CC=CC=C2NC(=CC(=O)O)N=C21 IYMYPOSBCZYACX-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940124597 therapeutic agent Drugs 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS DE CARBOXIMETILIDENCICLOHEPTIMIDAZOL Y METODO PARA PREPARARLOS. ESTOS DERIVADOS TIENEN LA FORMULA *FIG* (EN LA QUE R1 REPRESENTA UN ALQUILO INFERIOR; R2 REPRESENTA H O UN GRUPO ISOPROPILO; R3 REPRESENTA H, UN ALQUILO INFERIOR O -C(CH3)H-O-COOR4 (R4 ES UN ALQUILO INFERIOR O CICLOHEXILO); Y =CHCOOR3 ES UN GRUPO SUSTITUIDO EN LA POSICION 4 O LA 8; A REPRESENTA ESTOS COMPUESTOS SON UTILES COMO AGENTES ANTI-HIPERTENSIVOS Y ANTI-INSUFICIENCIA CARDIACA CONGESTIVA, Y COMO AGENTES REDUCTORES DE LA PRESION INTRAOCULAR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19015393 | 1993-07-30 |
Publications (3)
Publication Number | Publication Date |
---|---|
ES2085833A2 true ES2085833A2 (es) | 1996-06-01 |
ES2085833R ES2085833R (es) | 1996-06-16 |
ES2085833B1 ES2085833B1 (es) | 1997-03-16 |
Family
ID=16253305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09401628A Expired - Fee Related ES2085833B1 (es) | 1993-07-30 | 1994-07-22 | Derivados de carboximetilidencicloheptimidazol y metodo para prepararlos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5527815A (es) |
KR (1) | KR100303458B1 (es) |
BE (1) | BE1009376A4 (es) |
CH (1) | CH686726A5 (es) |
DE (1) | DE4427056B4 (es) |
ES (1) | ES2085833B1 (es) |
FR (1) | FR2708610B1 (es) |
GB (1) | GB2280438B (es) |
IT (1) | IT1276321B1 (es) |
NL (1) | NL9401247A (es) |
SE (1) | SE505562C2 (es) |
ZA (1) | ZA945190B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU767456B2 (en) | 1998-07-06 | 2003-11-13 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
JP4018816B2 (ja) * | 1998-09-08 | 2007-12-05 | 壽製薬株式会社 | シクロヘプテノン誘導体及びその製造方法並びにそれを利用してシクロヘプトイミダゾール誘導体を製造する方法 |
US7105513B2 (en) * | 2002-08-07 | 2006-09-12 | Sanofi-Avertis Deutschland Gmbh | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0432737A1 (en) * | 1989-12-11 | 1991-06-19 | G.D. Searle & Co. | Cycloheptimidazolone compounds as angiotensin II antagonists for control of hypertension |
EP0459136A1 (en) * | 1990-04-27 | 1991-12-04 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives, their production and use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4551452A (en) * | 1983-12-21 | 1985-11-05 | Pfizer Inc. | Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor |
GB8502258D0 (en) * | 1985-01-30 | 1985-02-27 | Lilly Industries Ltd | Organic compounds |
US4870186A (en) * | 1987-05-22 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
IL95975A (en) * | 1989-10-24 | 1997-06-10 | Takeda Chemical Industries Ltd | N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them |
CA2077897A1 (en) * | 1990-04-13 | 1991-10-14 | Robert G. Franz | Substituted benzimidazoles |
JP2707390B2 (ja) * | 1992-05-22 | 1998-01-28 | 壽製薬株式会社 | シクロヘプトイミダゾ−ル誘導体及びその製造方法並びにこれを含有する薬剤 |
-
1994
- 1994-07-15 ZA ZA945190A patent/ZA945190B/xx unknown
- 1994-07-21 IT IT94MI001541A patent/IT1276321B1/it active IP Right Grant
- 1994-07-22 ES ES09401628A patent/ES2085833B1/es not_active Expired - Fee Related
- 1994-07-26 BE BE9400701A patent/BE1009376A4/fr not_active IP Right Cessation
- 1994-07-26 FR FR9409214A patent/FR2708610B1/fr not_active Expired - Fee Related
- 1994-07-27 CH CH02374/94A patent/CH686726A5/de not_active IP Right Cessation
- 1994-07-27 KR KR1019940018326A patent/KR100303458B1/ko not_active IP Right Cessation
- 1994-07-28 GB GB9415208A patent/GB2280438B/en not_active Expired - Fee Related
- 1994-07-29 SE SE9402596A patent/SE505562C2/sv not_active IP Right Cessation
- 1994-07-29 NL NL9401247A patent/NL9401247A/nl active Search and Examination
- 1994-07-29 US US08/282,591 patent/US5527815A/en not_active Expired - Fee Related
- 1994-07-29 DE DE4427056A patent/DE4427056B4/de not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0432737A1 (en) * | 1989-12-11 | 1991-06-19 | G.D. Searle & Co. | Cycloheptimidazolone compounds as angiotensin II antagonists for control of hypertension |
EP0459136A1 (en) * | 1990-04-27 | 1991-12-04 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives, their production and use |
Non-Patent Citations (1)
Title |
---|
KUBO y col. Nonpeptide Angiotensin II Receptor Antagonists. Synthesis and Biological Activity of Benzimidazoles. J. Med. Chem., Vol. 36, n 12, Junio 93, pßginas 1772-1784 * |
Also Published As
Publication number | Publication date |
---|---|
CH686726A5 (de) | 1996-06-14 |
ITMI941541A0 (it) | 1994-07-21 |
GB9415208D0 (en) | 1994-09-21 |
GB2280438B (en) | 1997-07-30 |
SE9402596L (sv) | 1995-01-31 |
ZA945190B (en) | 1995-02-24 |
GB2280438A (en) | 1995-02-01 |
DE4427056B4 (de) | 2006-08-03 |
US5527815A (en) | 1996-06-18 |
ES2085833R (es) | 1996-06-16 |
SE9402596D0 (sv) | 1994-07-29 |
SE505562C2 (sv) | 1997-09-15 |
FR2708610A1 (fr) | 1995-02-10 |
IT1276321B1 (it) | 1997-10-28 |
FR2708610B1 (fr) | 1995-10-13 |
ITMI941541A1 (it) | 1996-01-21 |
BE1009376A4 (fr) | 1997-03-04 |
ES2085833B1 (es) | 1997-03-16 |
DE4427056A1 (de) | 1995-02-02 |
KR950003286A (ko) | 1995-02-16 |
KR100303458B1 (ko) | 2001-11-22 |
NL9401247A (nl) | 1995-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19940722 Kind code of ref document: R Effective date: 19940722 |
|
FD1A | Patent lapsed |
Effective date: 20060724 |