ES2084756T3 - Nuevos derivados de piridilo, medicamentos que contienen estos compuestos y procedimiento para su preparacion. - Google Patents

Nuevos derivados de piridilo, medicamentos que contienen estos compuestos y procedimiento para su preparacion.

Info

Publication number
ES2084756T3
ES2084756T3 ES91119889T ES91119889T ES2084756T3 ES 2084756 T3 ES2084756 T3 ES 2084756T3 ES 91119889 T ES91119889 T ES 91119889T ES 91119889 T ES91119889 T ES 91119889T ES 2084756 T3 ES2084756 T3 ES 2084756T3
Authority
ES
Spain
Prior art keywords
thromboxane
derivatives
compounds
addition
piridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91119889T
Other languages
English (en)
Inventor
Rainer Dr Dipl-Chem Soyka
Wolfgang Arzt Prof Dr D Eisert
Thomas Dr Arzt Und Dipl Muller
Johannes Dr Dipl- Weisenberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Application granted granted Critical
Publication of ES2084756T3 publication Critical patent/ES2084756T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Hydrogenated Pyridines (AREA)
  • Paper (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA NUEVA INVENCION TRATA DE LOS NUEVOS DERIVADOS DE PIRIDIL DE LA FORMULA GENERAL DONDE R SUB 1 A R SUB 6, A, X Y N SE DEFINEN EN LA PATENTE 1, CUYOS ENANTIOMERES, CUYOS ISOMEROS DE CIS Y TRANS Y JUNTO CON R SUB 4 Y R SUB 5, REPRESENTAN UN ENLACE CARBONO-CARBONO, ASI COMO SUS SALES ADITIVAS, CONCRETAMENTE PARA LA UTILIZACION FARMACEUTICA, CUYAS SALES ADITIVAS, QUE SON TOLERADAS BIOLOGICAMENTE, REPRESENTAN BASES ORGANICAS O INORGANICAS EN CASO DE QUE R SUB 6 REPRESENTA UN GRUPO DE HIDROXI, EL CUAL TIENE MUY BUENAS PROPIEDADES FARMACOLOGICAS, CONCRETAMENTE ES MUY EFICAZ CONTRA LA TROMBOSIS, MEDIANTE TROMBOXAN. ADEMAS, LOS NUEVOS COMPUESTOS REPRESENTAN SIMULTANEAMENTE NUEVOS ANTAGONISTAS DE TROMBOXAN (TRA) INHIBIDORES DE LA SINTESIS DEL TROMBOXAN (TSH). ADEMAS, SON EFICACES EN LA PRODUCCION PGE SUB 2.
ES91119889T 1990-11-22 1991-11-21 Nuevos derivados de piridilo, medicamentos que contienen estos compuestos y procedimiento para su preparacion. Expired - Lifetime ES2084756T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4037112A DE4037112A1 (de) 1990-11-22 1990-11-22 Neue pyridylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES2084756T3 true ES2084756T3 (es) 1996-05-16

Family

ID=6418696

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91119889T Expired - Lifetime ES2084756T3 (es) 1990-11-22 1991-11-21 Nuevos derivados de piridilo, medicamentos que contienen estos compuestos y procedimiento para su preparacion.

Country Status (19)

Country Link
EP (1) EP0487095B1 (es)
JP (1) JPH04275273A (es)
KR (1) KR920009799A (es)
AT (1) ATE134619T1 (es)
AU (1) AU640063B2 (es)
CA (1) CA2055950A1 (es)
DE (2) DE4037112A1 (es)
DK (1) DK0487095T3 (es)
ES (1) ES2084756T3 (es)
FI (1) FI915484A (es)
GR (1) GR3019783T3 (es)
HU (1) HU213676B (es)
IE (1) IE74248B1 (es)
IL (1) IL100097A (es)
NO (1) NO175634C (es)
NZ (1) NZ240677A (es)
PT (1) PT99571B (es)
RU (1) RU2028292C1 (es)
ZA (1) ZA919205B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4216364A1 (de) * 1991-12-14 1993-11-25 Thomae Gmbh Dr K Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
TWI290549B (en) * 2000-06-02 2007-12-01 Astrazeneca Ab Process for the preparation of cyclopropyl carboxylic acid ester and derivatives
DE10225635C1 (de) * 2002-06-07 2003-12-24 Aventis Pharma Gmbh N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
FI20055498A0 (fi) * 2005-09-16 2005-09-16 Biotie Therapies Corp Sulfonamidijohdannaisia
EP2928860A1 (en) * 2012-12-10 2015-10-14 H. Lundbeck A/S New positive allosteric modulators of nicotinic acetylcholine receptor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518602A (en) * 1982-10-07 1985-05-21 Takeda Chemical Industries, Ltd. Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase
GB8708233D0 (en) * 1987-04-07 1987-05-13 Smith Kline French Lab Pharmaceutically active compounds
DE3932403A1 (de) * 1989-05-12 1991-04-11 Thomae Gmbh Dr K Neue arylsulfonamide, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
IE74248B1 (en) 1997-07-16
KR920009799A (ko) 1992-06-25
PT99571B (pt) 1999-04-30
GR3019783T3 (en) 1996-07-31
HU213676B (en) 1997-09-29
RU2028292C1 (ru) 1995-02-09
EP0487095A1 (de) 1992-05-27
NO175634C (no) 1994-11-09
HU913644D0 (en) 1992-02-28
IL100097A0 (en) 1992-08-18
HUT60472A (en) 1992-09-28
NO914567D0 (no) 1991-11-21
DE4037112A1 (de) 1992-05-27
ZA919205B (en) 1993-05-21
IE914048A1 (en) 1992-06-03
DK0487095T3 (da) 1996-06-24
AU8796491A (en) 1992-05-28
ATE134619T1 (de) 1996-03-15
NO175634B (es) 1994-08-01
NO914567L (no) 1992-05-25
IL100097A (en) 1995-07-31
AU640063B2 (en) 1993-08-12
JPH04275273A (ja) 1992-09-30
NZ240677A (en) 1994-12-22
FI915484A0 (fi) 1991-11-21
FI915484A (fi) 1992-05-23
DE59107462D1 (de) 1996-04-04
PT99571A (pt) 1992-10-30
CA2055950A1 (en) 1992-05-23
EP0487095B1 (de) 1996-02-28

Similar Documents

Publication Publication Date Title
ES2083394T3 (es) Nuevas arilsulfonamidas, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
DE59202241D1 (de) Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung.
ES2084756T3 (es) Nuevos derivados de piridilo, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
ATE445589T1 (de) Neue retinoidderivate und eine pharmazeutische anti-krebs-zusammensetzung, die diese verbindungen enthält
ATE100102T1 (de) Substituierte derivate von 20,21dinoreburnamenin, verfahren zur herstellung und so hergestellte zwischenprodukte, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammenstellungen.
ES2062214T3 (es) Derivados de aminooligohidroxi inhibidores de renina.
SE9203824L (sv) Bensofuranylimidazol-derivat, foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande desamma
FR2655042B1 (fr) Nouvelles benzothiazolinones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ATE195311T1 (de) Phenoxyethylamin-derivate mit hoher affinität fur den 5-ht1a-rezeptor, verfahren zu ihrer herstellung, ihre verwendung als medikamente und sie enthaltende pharmazeutische zusammensetzungen
ES2063008T3 (es) Nuevos (aril o heteroarilmetil)-2,2'-di-1h-imidazoles.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 487095

Country of ref document: ES