ES2082973T3 - Dispositivo para administracion iontoforetica de farmacos. - Google Patents
Dispositivo para administracion iontoforetica de farmacos.Info
- Publication number
- ES2082973T3 ES2082973T3 ES91907000T ES91907000T ES2082973T3 ES 2082973 T3 ES2082973 T3 ES 2082973T3 ES 91907000 T ES91907000 T ES 91907000T ES 91907000 T ES91907000 T ES 91907000T ES 2082973 T3 ES2082973 T3 ES 2082973T3
- Authority
- ES
- Spain
- Prior art keywords
- electrode element
- active
- active electrode
- layer
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/02—Homopolymers or copolymers of acids; Metal or ammonium salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
- C09J133/24—Homopolymers or copolymers of amides or imides
- C09J133/26—Homopolymers or copolymers of acrylamide or methacrylamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0444—Membrane
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
- C08L2666/04—Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Electrotherapy Devices (AREA)
- Medicinal Preparation (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Two-Way Televisions, Distribution Of Moving Picture Or The Like (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Electrophonic Musical Instruments (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
SE PRESENTA UN DISPOSITIVO IONTOFORETICO QUE TIENE UN ELECTRODO ACTIVO DE DOS CAPAS (20). EL ELEMENTO ACTIVO ESTA COMPUESTO DE UN HIDROGEL DE CONTACTO (21) QUE SE SUPERPONE A LA PIEL Y CAPAS PORTADORAS (22). LA CAPA PORTADORA CONTIENE UN AGENTE ACTIVO DISPERSO O DISUELTO. EL ELECTRODO ACTIVO MANTIENE AL AGENTE ACTIVO EN FORMA ESTABLE Y PERMITE UN TRANSPORTE EFICIENTE DEL AGENTE ACTIVO HASTA EL RECEPTOR. TAMBIEN SE PRESENTA UN DISPOSITIVO IONTOFORETICO QUE TIENE UN ELECTRODO ACTIVO DE CAPA SIMPLE. LA CAPA SIMPLE ES UN HIDROGEL MANUFACTURADO O SUBSTANCIALMENTE SECO Y CAPAZ DE SER HIDRATADO ANTES DE SU USO. EL HIDROGEL DE CONTACTO CON LA PIEL DEL ELECTRODO ACTIVO DE DOS CAPAS ES PREFERIBLEMENTE ADHESIVO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50284190A | 1990-03-30 | 1990-03-30 | |
US67531391A | 1991-03-26 | 1991-03-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2082973T3 true ES2082973T3 (es) | 1996-04-01 |
Family
ID=27054298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91907000T Expired - Lifetime ES2082973T3 (es) | 1990-03-30 | 1991-03-26 | Dispositivo para administracion iontoforetica de farmacos. |
Country Status (12)
Country | Link |
---|---|
US (2) | US5423739A (es) |
EP (1) | EP0521988B1 (es) |
AT (1) | ATE131392T1 (es) |
AU (1) | AU657681B2 (es) |
CA (1) | CA2079315C (es) |
DE (1) | DE69115471T2 (es) |
DK (1) | DK0521988T3 (es) |
ES (1) | ES2082973T3 (es) |
FI (1) | FI924382A (es) |
IE (1) | IE74127B1 (es) |
NO (1) | NO923770L (es) |
PT (1) | PT97217B (es) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2082973T3 (es) * | 1990-03-30 | 1996-04-01 | Alza Corp | Dispositivo para administracion iontoforetica de farmacos. |
WO1995028144A1 (en) * | 1994-04-13 | 1995-10-26 | Ciba-Geigy Ag | Temporally controlled drug delivery systems |
CA2154928C (en) * | 1994-08-19 | 2000-01-04 | Katherine Louise Mayer | Body fitting compound sanitary napkin |
JPH08155041A (ja) * | 1994-12-05 | 1996-06-18 | Advance Co Ltd | イオントフォレシス用新規高能率電極システム |
US5990179A (en) * | 1995-04-28 | 1999-11-23 | Alza Corporation | Composition and method of enhancing electrotransport agent delivery |
IE960375A1 (en) * | 1995-06-05 | 1996-12-11 | Alza Corp | Device for transdermal electrotransport delivery of fentanyl¹and sufentanil |
US6881208B1 (en) * | 1995-06-05 | 2005-04-19 | Joseph B. Phipps | Method and device for transdermal electrotransport delivery of fentanyl and sufentanil |
US5788666A (en) * | 1995-06-15 | 1998-08-04 | Empi, Inc. | Iontophoresis electrode |
US5840056A (en) * | 1995-06-15 | 1998-11-24 | Empi, Inc. | Iontophoresis electrode |
US5989409A (en) * | 1995-09-11 | 1999-11-23 | Cygnus, Inc. | Method for glucose sensing |
WO1997048443A1 (en) * | 1996-06-19 | 1997-12-24 | Becton Dickinson And Company | Iontophoretic delivery of cell adhesion inhibitors |
US5941843A (en) * | 1996-07-12 | 1999-08-24 | Empi, Inc. | Iontophoresis electrode |
US5871461A (en) * | 1996-07-12 | 1999-02-16 | Empi, Inc. | Method of making an iontophoresis electrode |
US5857993A (en) * | 1996-07-12 | 1999-01-12 | Empi, Inc. | Process of making an iontophoresis electrode |
US5797867A (en) * | 1996-09-27 | 1998-08-25 | Becton Dickinson And Company | Iontophoretic drug delivery system, including method for activating same for attachment to patient |
US6246904B1 (en) * | 1996-12-17 | 2001-06-12 | Alza Corporation | Electrotransport drug delivery reservoirs containing inert fillers |
CA2271167C (en) | 1996-12-20 | 2007-01-09 | Alza Corporation | Device and method for enhancing transdermal agent flux |
US6139718A (en) * | 1997-03-25 | 2000-10-31 | Cygnus, Inc. | Electrode with improved signal to noise ratio |
US6119036A (en) | 1997-03-26 | 2000-09-12 | The Board Of Regents Of The University Of Oklahoma | Iontophoretic transdermal delivery device |
US6375990B1 (en) | 1997-10-09 | 2002-04-23 | Emory University | Method and devices for transdermal delivery of lithium |
US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
KR100561892B1 (ko) * | 1997-12-11 | 2006-03-16 | 알자 코포레이션 | 경피성 작용제 유동률을 증진시키기 위한 장치 |
US6050988A (en) * | 1997-12-11 | 2000-04-18 | Alza Corporation | Device for enhancing transdermal agent flux |
EP1911488A3 (en) | 1997-12-11 | 2008-12-03 | Alza Corporation | Device for enhancing transdermal agent flux |
CN1206004C (zh) | 1997-12-11 | 2005-06-15 | 阿尔扎有限公司 | 增强透皮物剂流量的装置 |
US6163720A (en) * | 1997-12-18 | 2000-12-19 | Alza Corporation | Layered rate controlling membranes for use in an electrotransport device |
US6096726A (en) | 1998-03-11 | 2000-08-01 | Surface Solutions Laboratories Incorporated | Multicomponent complex for use with substrate |
US6117296A (en) * | 1998-07-21 | 2000-09-12 | Thomson; Timothy | Electrically controlled contractile polymer composite |
US20050147690A1 (en) * | 1998-09-25 | 2005-07-07 | Masters David B. | Biocompatible protein particles, particle devices and methods thereof |
US7662409B2 (en) * | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
IL144728A0 (en) | 1999-02-10 | 2002-06-30 | Gmp Drug Delivery Inc | Iontophoresis, electroporation and combination patches for local drug delivery |
WO2001041863A1 (en) | 1999-12-10 | 2001-06-14 | Alza Corporation | Device and method for enhancing microprotrusion skin piercing |
AU2001241483A1 (en) | 2000-02-18 | 2001-08-27 | University Of Utah Research Foundation | Methods for extracting substances using alternating current |
US6512950B2 (en) | 2000-02-18 | 2003-01-28 | University Of Utah Research Foundation | Methods for delivering agents using alternating current |
WO2001076553A2 (en) * | 2000-04-06 | 2001-10-18 | Sontra Medical, Inc. | Method and device for enhanced transdermal drug delivery |
US7137975B2 (en) * | 2001-02-13 | 2006-11-21 | Aciont, Inc. | Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent |
US7572288B2 (en) * | 2001-07-20 | 2009-08-11 | Microvention, Inc. | Aneurysm treatment device and method of use |
DE10141254C1 (de) * | 2001-08-23 | 2003-04-03 | Susann Edel | Iontophorese-Kaltkontaktelektrodensystem zur gleichzeitigen Anwendung der Kühlung und der Iontophorese |
CA2483778A1 (en) * | 2002-04-29 | 2003-11-13 | Gel-Del Technologies, Inc. | Biomatrix structural containment and fixation systems and methods of use thereof |
US20040015145A1 (en) * | 2002-07-16 | 2004-01-22 | The Procter & Gamble Company | Absorbent article having a graphic visible through body contacting surface |
EP1556061B1 (en) * | 2002-10-04 | 2007-04-18 | Photokinetix Inc | Photokinetic delivery of biologically active substances using pulsed incoherent light |
WO2004057057A1 (en) * | 2002-12-23 | 2004-07-08 | Council Of Scientific And Industrial Research | Process for manufacture of proton conductive polymer gel useful as backfill for sacrificial and impressed current anode systems |
US8465537B2 (en) * | 2003-06-17 | 2013-06-18 | Gel-Del Technologies, Inc. | Encapsulated or coated stent systems |
CA2537315C (en) | 2003-08-26 | 2015-12-08 | Gel-Del Technologies, Inc. | Protein biomaterials and biocoacervates and methods of making and using thereof |
US8529939B2 (en) * | 2003-12-08 | 2013-09-10 | Gel-Del Technologies, Inc. | Mucoadhesive drug delivery devices and methods of making and using thereof |
WO2006055729A1 (en) * | 2004-11-16 | 2006-05-26 | Transcutaneous Technologies Inc. | Iontophoretic device and method for administering immune response-enhancing agents and compositions |
JP2006296511A (ja) * | 2005-04-15 | 2006-11-02 | Transcutaneous Technologies Inc | 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ |
US8295922B2 (en) | 2005-08-08 | 2012-10-23 | Tti Ellebeau, Inc. | Iontophoresis device |
US8386030B2 (en) * | 2005-08-08 | 2013-02-26 | Tti Ellebeau, Inc. | Iontophoresis device |
US20070088332A1 (en) * | 2005-08-22 | 2007-04-19 | Transcutaneous Technologies Inc. | Iontophoresis device |
US20090254018A1 (en) * | 2005-08-24 | 2009-10-08 | Mizuo Nakayama | Electrode assembly for freezing-type iontophoresis device |
JPWO2007026672A1 (ja) * | 2005-08-29 | 2009-03-05 | Tti・エルビュー株式会社 | イオントフォレーシス用汎用性電解液組成物 |
US7890164B2 (en) | 2005-09-15 | 2011-02-15 | Tti Ellebeau, Inc. | Iontophoresis device |
US20070083147A1 (en) * | 2005-09-30 | 2007-04-12 | Transcutaneous Technologies Inc. | Iontophoresis apparatus and method to deliver antibiotics to biological interfaces |
JP2009509659A (ja) * | 2005-09-30 | 2009-03-12 | Tti・エルビュー株式会社 | 生体界面への活性物質の送達のイオントフォレーシス装置及び方法 |
EP1931417A2 (en) * | 2005-09-30 | 2008-06-18 | Transcutaneous Technologies Inc. | Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles |
US20070078374A1 (en) * | 2005-09-30 | 2007-04-05 | Transcutaneous Technologies Inc. | Iontophoretic delivery of vesicle-encapsulated active agents |
KR20080066712A (ko) * | 2005-09-30 | 2008-07-16 | 티티아이 엘뷰 가부시키가이샤 | 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법 |
US7574256B2 (en) * | 2005-09-30 | 2009-08-11 | Tti Ellebeau, Inc. | Iontophoretic device and method of delivery of active agents to biological interface |
WO2007041322A2 (en) * | 2005-09-30 | 2007-04-12 | Tti Ellebeau, Inc. | Iontophoretic delivery of active agents conjugated to nanoparticles |
JP2009522011A (ja) * | 2005-12-30 | 2009-06-11 | Tti・エルビュー株式会社 | 活性物質を生体界面に送達するイオントフォレーシスシステム、装置及び方法 |
WO2007123707A1 (en) * | 2006-03-30 | 2007-11-01 | Tti Ellebeau, Inc. | Controlled release membrane and methods of use |
JP2010504798A (ja) * | 2006-09-29 | 2010-02-18 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 経皮ドラッグデリバリーのための電気的に活性化されたゲル配列 |
US20080193514A1 (en) * | 2006-11-02 | 2008-08-14 | Transcu Ltd. | Compostions and methods for iontophoresis delivery of active ingredients through hair follicles |
JP5383497B2 (ja) | 2006-12-01 | 2014-01-08 | Tti・エルビュー株式会社 | 装置、例として経皮送達装置に給電し且つ/又は当該装置を制御するシステム及び装置 |
WO2008087803A1 (ja) * | 2007-01-16 | 2008-07-24 | Hokkaido University | 抗酸化成分を封入したイオントフォレーシス用リポソーム製剤 |
US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
JP2010187707A (ja) * | 2007-06-12 | 2010-09-02 | Hokkaido Univ | インスリンを封入したイオントフォレーシス用リポソーム製剤 |
JP5734650B2 (ja) | 2007-06-25 | 2015-06-17 | マイクロベンション インコーポレイテッド | 自己拡張プロテーゼ |
ES2454974T3 (es) | 2007-06-27 | 2014-04-14 | The General Hospital Corporation | Aparato para la inhibición óptica de la terapia fotodinámica |
US8195287B2 (en) | 2007-12-05 | 2012-06-05 | The Invention Science Fund I, Llc | Method for electrical modulation of neural conduction |
US8170658B2 (en) | 2007-12-05 | 2012-05-01 | The Invention Science Fund I, Llc | System for electrical modulation of neural conduction |
US8165669B2 (en) | 2007-12-05 | 2012-04-24 | The Invention Science Fund I, Llc | System for magnetic modulation of neural conduction |
US8170660B2 (en) | 2007-12-05 | 2012-05-01 | The Invention Science Fund I, Llc | System for thermal modulation of neural activity |
US8180446B2 (en) | 2007-12-05 | 2012-05-15 | The Invention Science Fund I, Llc | Method and system for cyclical neural modulation based on activity state |
US8165668B2 (en) | 2007-12-05 | 2012-04-24 | The Invention Science Fund I, Llc | Method for magnetic modulation of neural conduction |
US8160695B2 (en) | 2007-12-05 | 2012-04-17 | The Invention Science Fund I, Llc | System for chemical modulation of neural activity |
US8233976B2 (en) | 2007-12-05 | 2012-07-31 | The Invention Science Fund I, Llc | System for transdermal chemical modulation of neural activity |
EP2237770A4 (en) * | 2007-12-26 | 2011-11-09 | Gel Del Technologies Inc | BIOCOMPATIBLE PROTEIN PARTICLES, PARTICLE DEVICES AND METHODS THEREOF |
US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
CA2728975C (en) | 2008-06-19 | 2016-06-07 | Lts Lohmann Therapie-Systeme Ag | Composition for transdermal delivery of cationic active agents |
US20100022494A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
US20100022991A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and device for maintaining physiological levels of steroid hormone in a subject |
US20100022497A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing a cardiovascular disease or condition utilizing estrogen receptor modulators based on APOE allelic profile of a mammalian subject |
US20100061976A1 (en) * | 2008-07-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject |
US10016534B2 (en) | 2008-11-17 | 2018-07-10 | Gel-Del Technologies, Inc. | Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof |
SG175341A1 (en) * | 2009-05-08 | 2011-11-28 | Isis Biopolymer Inc | Iontophoretic device with improved counterelectrode |
US20110092881A1 (en) * | 2009-05-08 | 2011-04-21 | Isis Biopolymer Inc. | Iontophoretic device with contact sensor |
NZ599527A (en) | 2009-11-09 | 2014-04-30 | Spotlight Technology Partners Llc | Fragmented hydrogels |
NZ599524A (en) | 2009-11-09 | 2014-04-30 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
CA2835427A1 (en) | 2011-05-11 | 2012-11-15 | Microvention, Inc. | Device for occluding a lumen |
EP2886153A1 (de) | 2013-12-20 | 2015-06-24 | LTS LOHMANN Therapie-Systeme AG | System für die transdermale Abgabe von Wirkstoff |
EP3181117A1 (en) * | 2015-12-15 | 2017-06-21 | L'oreal | Vitamin c composition and an iontophoresis method for its delivery |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3998215A (en) * | 1968-12-18 | 1976-12-21 | Minnesota Mining And Manufacturing Company | Bio-medical electrode conductive gel pads |
CS159361B1 (es) * | 1970-09-08 | 1975-01-31 | ||
CS164542B1 (es) * | 1973-02-15 | 1975-11-07 | ||
US3991755A (en) * | 1973-07-27 | 1976-11-16 | Medicon, Inc. | Iontophoresis apparatus for applying local anesthetics |
US3929741A (en) * | 1974-07-16 | 1975-12-30 | Datascope Corp | Hydrophilic acrylamido polymers |
US4094822A (en) * | 1974-12-26 | 1978-06-13 | Kater John A R | Bio-event electrode material |
US3994302A (en) * | 1975-08-14 | 1976-11-30 | Medtronic, Inc. | Stimulation electrode of ion-exchange material |
US4051842A (en) * | 1975-09-15 | 1977-10-04 | International Medical Corporation | Electrode and interfacing pad for electrical physiological systems |
US4274420A (en) * | 1975-11-25 | 1981-06-23 | Lectec Corporation | Monitoring and stimulation electrode |
US4066078A (en) * | 1976-02-05 | 1978-01-03 | Johnson & Johnson | Disposable electrode |
DE2626348C3 (de) * | 1976-06-11 | 1980-01-31 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Implantierbare Dosiereinrichtung |
US4141359A (en) * | 1976-08-16 | 1979-02-27 | University Of Utah | Epidermal iontophoresis device |
US4352359A (en) * | 1977-08-19 | 1982-10-05 | Minnesota Mining And Manufacturing Company | Biomedical electrode |
US4273135A (en) * | 1977-08-19 | 1981-06-16 | Minnesota Mining And Manufacturing Company | Biomedical electrode |
CA1153427A (en) * | 1978-12-11 | 1983-09-06 | Patrick T. Cahalan | Tape electrode |
GB2046764B (en) * | 1979-02-08 | 1983-04-20 | Matburn Holdings Ltd | Polymeric sealant compositions |
US4524087A (en) * | 1980-01-23 | 1985-06-18 | Minnesota Mining And Manufacturing Company | Conductive adhesive and biomedical electrode |
US4383529A (en) * | 1980-11-03 | 1983-05-17 | Wescor, Inc. | Iontophoretic electrode device, method and gel insert |
US4820263A (en) * | 1981-03-06 | 1989-04-11 | Medtronic, Inc. | Apparatus and method for iontophoretic drug delivery |
US4768523A (en) * | 1981-04-29 | 1988-09-06 | Lifecore Biomedical, Inc. | Hydrogel adhesive |
JPS5810066A (ja) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
US4419092A (en) * | 1981-11-06 | 1983-12-06 | Motion Control, Inc. | Iontophoretic electrode structure |
US4526176A (en) * | 1981-12-22 | 1985-07-02 | Frantz Medical Development Ltd. | Long-life biomedical application device, particularly electrode, and method of transferring electrical current |
US4693711A (en) * | 1981-12-22 | 1987-09-15 | Bremer Roger E | Long-life biomedical transcutaneous drug application device and method of transcutaneous application of drugs |
US4699146A (en) * | 1982-02-25 | 1987-10-13 | Valleylab, Inc. | Hydrophilic, elastomeric, pressure-sensitive adhesive |
US4557723A (en) * | 1983-08-18 | 1985-12-10 | Drug Delivery Systems Inc. | Applicator for the non-invasive transcutaneous delivery of medicament |
US4622031A (en) * | 1983-08-18 | 1986-11-11 | Drug Delivery Systems Inc. | Indicator for electrophoretic transcutaneous drug delivery device |
US4708716A (en) * | 1983-08-18 | 1987-11-24 | Drug Delivery Systems Inc. | Transdermal drug applicator |
US4747845A (en) * | 1983-10-17 | 1988-05-31 | Enquay Pharmaceutical Associates | Synthetic resin matrix system for the extended delivery of drugs |
US4601286A (en) * | 1984-04-20 | 1986-07-22 | Kaufman Jack W | Article for the protection of living tissues |
US4747819A (en) * | 1984-10-29 | 1988-05-31 | Medtronic, Inc. | Iontophoretic drug delivery |
US4655767A (en) * | 1984-10-29 | 1987-04-07 | Dow Corning Corporation | Transdermal drug delivery devices with amine-resistant silicone adhesives |
US4744787A (en) * | 1984-10-29 | 1988-05-17 | Medtronic, Inc. | Iontophoresis apparatus and methods of producing same |
CA1267937A (en) * | 1984-10-29 | 1990-04-17 | Joseph Bradley Phipps | Iontophoretic drug delivery |
US4585652A (en) * | 1984-11-19 | 1986-04-29 | Regents Of The University Of Minnesota | Electrochemical controlled release drug delivery system |
US4593053A (en) * | 1984-12-07 | 1986-06-03 | Medtronic, Inc. | Hydrophilic pressure sensitive biomedical adhesive composition |
GB8509978D0 (en) * | 1985-04-18 | 1985-05-30 | Juhasz L | Wound dressings |
US4645502A (en) * | 1985-05-03 | 1987-02-24 | Alza Corporation | Transdermal delivery of highly ionized fat insoluble drugs |
DE3533114A1 (de) * | 1985-09-17 | 1987-03-26 | Berolina Kunststoff | Teilbarer flaschenkasten |
US4722726A (en) * | 1986-02-12 | 1988-02-02 | Key Pharmaceuticals, Inc. | Method and apparatus for iontophoretic drug delivery |
US4915685A (en) * | 1986-03-19 | 1990-04-10 | Petelenz Tomasz J | Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange |
IE60941B1 (en) * | 1986-07-10 | 1994-09-07 | Elan Transdermal Ltd | Transdermal drug delivery device |
US4734090A (en) * | 1986-07-18 | 1988-03-29 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator |
JPS63102768A (ja) * | 1986-10-20 | 1988-05-07 | 山之内製薬株式会社 | イオントフオレ−シス用の新規プラスタ−構造体 |
WO1988003821A1 (en) * | 1986-11-21 | 1988-06-02 | Boston University | Electrode assembly for transdermal drug delivery |
US4786277A (en) * | 1986-11-21 | 1988-11-22 | Trustees Of Boston University | Electrodes, electrode assemblies, methods, and systems for tissue stimulation |
US4731049A (en) * | 1987-01-30 | 1988-03-15 | Ionics, Incorporated | Cell for electrically controlled transdermal drug delivery |
EP0318776A1 (en) * | 1987-12-04 | 1989-06-07 | Robert Tapper | Method and apparatus for minimizing skin injury with electrode use |
US4814168A (en) * | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
IL86076A (en) * | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
US4927408A (en) * | 1988-10-03 | 1990-05-22 | Alza Corporation | Electrotransport transdermal system |
US5057072A (en) * | 1988-10-28 | 1991-10-15 | Medtronic, Inc. | Iontophoresis electrode |
US5084008A (en) * | 1989-12-22 | 1992-01-28 | Medtronic, Inc. | Iontophoresis electrode |
ES2082973T3 (es) * | 1990-03-30 | 1996-04-01 | Alza Corp | Dispositivo para administracion iontoforetica de farmacos. |
US5084006A (en) * | 1990-03-30 | 1992-01-28 | Alza Corporation | Iontopheretic delivery device |
-
1991
- 1991-03-26 ES ES91907000T patent/ES2082973T3/es not_active Expired - Lifetime
- 1991-03-26 AT AT91907000T patent/ATE131392T1/de not_active IP Right Cessation
- 1991-03-26 DE DE69115471T patent/DE69115471T2/de not_active Expired - Lifetime
- 1991-03-26 AU AU75652/91A patent/AU657681B2/en not_active Ceased
- 1991-03-26 CA CA002079315A patent/CA2079315C/en not_active Expired - Lifetime
- 1991-03-26 DK DK91907000.3T patent/DK0521988T3/da active
- 1991-03-26 EP EP91907000A patent/EP0521988B1/en not_active Expired - Lifetime
- 1991-03-28 IE IE108291A patent/IE74127B1/en not_active IP Right Cessation
- 1991-04-01 PT PT97217A patent/PT97217B/pt not_active IP Right Cessation
-
1992
- 1992-09-28 NO NO92923770A patent/NO923770L/no unknown
- 1992-09-29 FI FI924382A patent/FI924382A/fi not_active Application Discontinuation
-
1993
- 1993-07-30 US US08/100,071 patent/US5423739A/en not_active Expired - Lifetime
-
1994
- 1994-12-01 US US08/347,694 patent/US5558633A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0521988B1 (en) | 1995-12-13 |
US5558633A (en) | 1996-09-24 |
PT97217A (pt) | 1992-01-31 |
IE74127B1 (en) | 1997-07-02 |
US5423739A (en) | 1995-06-13 |
AU657681B2 (en) | 1995-03-23 |
ATE131392T1 (de) | 1995-12-15 |
FI924382A0 (fi) | 1992-09-29 |
NO923770D0 (no) | 1992-09-28 |
CA2079315C (en) | 2003-04-15 |
NO923770L (no) | 1992-11-30 |
IE911082A1 (en) | 1991-10-09 |
DE69115471D1 (de) | 1996-01-25 |
EP0521988A1 (en) | 1993-01-13 |
AU7565291A (en) | 1991-10-30 |
PT97217B (pt) | 1998-11-30 |
DE69115471T2 (de) | 1996-05-02 |
FI924382A (fi) | 1992-09-29 |
DK0521988T3 (da) | 1996-04-29 |
CA2079315A1 (en) | 1991-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2082973T3 (es) | Dispositivo para administracion iontoforetica de farmacos. | |
ES2151025T3 (es) | Vendajes para heridas. | |
ATE124270T1 (de) | Pharmazeutisch aktive bestandteile enthaltende adhesivpflaster. | |
ATE130774T1 (de) | Galvanisch aktives transdermales therapeutisches system. | |
CA2229185A1 (en) | Plaster structure for iontophoresis | |
MY100066A (en) | Multicompartmentalized dermal and transdermal patches. | |
BR8404119A (pt) | Aplicador para migracao eletroforetica de um medicamento em solucao ou suspensao ionica,atraves da pele,dentro de uma corrente do sangue de um paciente | |
DK662887A (da) | Fladeformigt terapeutisk system, fremgangsmaade til fremstilling deraf og anvendelse deraf | |
DE69330710D1 (de) | Elektrode und gebrauchsfertige Schicht vom Gel zum Verwenden mit einer Elektrode | |
BR0100151A (pt) | Artigo absorvente | |
DE3685895D1 (de) | Dosierungssystem fuer transdermale absorption von arzneimittelwirkstoffen. | |
SE7906942L (sv) | Doseringsformkropp | |
KR890700375A (ko) | 피부에 유효약제를 조절하여 투여하는 유효약제-함유 플래스터 | |
MY111126A (en) | Transdermal therapeutic system comprising the active substance acetylsalicylic acid. | |
DK324687A (da) | Transdermalt farmeceutisk praeparat | |
ES2044842T3 (es) | Matriz de soporte de colageno topico biologicamente activo, usos cosmeticos y farmaceuticos y un procedimiento para su preparacion. | |
GB2076660A (en) | Application unit for epicutaneous testing or treatment | |
NO982621L (no) | Overflate-stabilisert farmas°ytisk bearbeiding for anvendelse pÕ huden | |
GB1490065A (en) | Dressings | |
JPS6334695Y2 (es) | ||
ATE173163T1 (de) | Estradiol-tts mit wasserbindenden zusätzen | |
JPS6217063Y2 (es) | ||
JPS609223Y2 (ja) | 貼薬シ−ト | |
ZA787352B (en) | Pharmacologically active heterocyclic compounds and their use in medicine | |
ES1037774U (es) | Aposito antiseptico aplicable a puntos de insercion de cateteres. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 521988 Country of ref document: ES |