ES2078034T3 - Tecnica de carga para preparar liposomas que contienen farmacos. - Google Patents

Tecnica de carga para preparar liposomas que contienen farmacos.

Info

Publication number
ES2078034T3
ES2078034T3 ES92904373T ES92904373T ES2078034T3 ES 2078034 T3 ES2078034 T3 ES 2078034T3 ES 92904373 T ES92904373 T ES 92904373T ES 92904373 T ES92904373 T ES 92904373T ES 2078034 T3 ES2078034 T3 ES 2078034T3
Authority
ES
Spain
Prior art keywords
membrane permeability
liposomes containing
cationic
anionic
containing drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92904373T
Other languages
English (en)
Inventor
Eric A Forssen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexstar Pharmaceuticals Inc
Original Assignee
Vestar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vestar Inc filed Critical Vestar Inc
Application granted granted Critical
Publication of ES2078034T3 publication Critical patent/ES2078034T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCESO PARA CARGA DE DROGAS CATIONICAS, ANIONICAS O IONIZABLES A TRAVES DE MEMBRANAS LIPIDAS BICAPA EN AUSENCIA DE GRADIENTE DE PH COMPRENDE LA FORMACION DE LIPOSOMAS EN UN MEDIO ACUOSO QUE CONTIENE UNA COMBINACION DE, BIEN LA SAL DE UN ANION CON MEMBRANA DE ALTA PERMEABILIDAD Y UN CATION CON MEMBRANA DE BAJA PERMEABILIDAD SI EL COMPUESTO A SER ATRAPADO ES UNA DROGA ANIONICA O TIENE UN POTENCIAL ANIONICO, O BIEN LA SAL DE UN CATION CON MEMBRANA DE ALTA PERMEABILIDAD Y UN ANION CON MEMBRANA DE BAJA PERMEABILIDAD SI EL COMPUESTO A SER ATRAPADO ES UNA DROGA CATIONICA O TIENE POTENCIAL CATIONICO.
ES92904373T 1991-07-03 1991-07-03 Tecnica de carga para preparar liposomas que contienen farmacos. Expired - Lifetime ES2078034T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1991/004807 WO1993000888A1 (en) 1991-07-03 1991-07-03 Loading technique for preparing drug containing liposomes

Publications (1)

Publication Number Publication Date
ES2078034T3 true ES2078034T3 (es) 1995-12-01

Family

ID=25676859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92904373T Expired - Lifetime ES2078034T3 (es) 1991-07-03 1991-07-03 Tecnica de carga para preparar liposomas que contienen farmacos.

Country Status (10)

Country Link
EP (1) EP0592446B1 (es)
JP (1) JPH06511470A (es)
AT (1) ATE128621T1 (es)
AU (1) AU654835B2 (es)
CA (1) CA2111593A1 (es)
DE (1) DE69113640T2 (es)
DK (1) DK0592446T3 (es)
ES (1) ES2078034T3 (es)
GR (1) GR3017836T3 (es)
WO (1) WO1993000888A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714163A (en) * 1994-06-27 1998-02-03 Nexstar Pharmaceuticals, Inc. Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties
US5800833A (en) * 1995-02-27 1998-09-01 University Of British Columbia Method for loading lipid vesicles
WO1996032930A1 (en) * 1995-04-18 1996-10-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
US5827532A (en) * 1997-01-31 1998-10-27 The Reagents Of The University Of California Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations
CA2304096C (en) 1997-09-18 2003-09-09 Skyepharma Inc. Sustained-release liposomal anesthetic compositions
US6120800A (en) * 1997-09-25 2000-09-19 Nexstar Pharmaceuticals, Inc. Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties
JP4575592B2 (ja) 1997-11-14 2010-11-04 パシラ ファーマシューティカルズ インコーポレーテッド 多小胞リポソームの製造
JP4649841B2 (ja) * 2004-02-18 2011-03-16 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法、およびリポソーム含有製剤
JP4971142B2 (ja) 2004-05-03 2012-07-11 ヘルメス バイオサイエンシズ インコーポレーティッド 薬物送達に有用なリポソーム
US8658203B2 (en) 2004-05-03 2014-02-25 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery to the brain
BRPI0516265A (pt) 2004-10-06 2008-08-26 Bc Cancer Agency composição, uso da mesma, método de aumentar a retenção de um agente terapêutico dentro dos lipossomas, formulação lipossomal, e, uso de um agente terapêutico encapsulado lipossomalmente
US20150004219A1 (en) 2012-02-02 2015-01-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Stable liposomes for drug delivery
EP3115039B1 (de) * 2015-07-09 2021-12-15 beniag GmbH Verfahren zum herstellen einer fusionsmischung zur übertragung eines geladenen moleküls in und/oder durch eine lipidmembran
JP6941606B2 (ja) 2015-10-16 2021-09-29 イプセン バイオファーム リミティド 安定化カンプトテシン医薬組成物
KR102337566B1 (ko) 2017-07-24 2021-12-14 파모사 바이오팜 인코포레이티드 약산성 약물을 포함하는 리포솜 조성물 및 이의 용도
US20220018060A1 (en) * 2018-11-15 2022-01-20 The Regents Of The University Of California Vesicle-coated fibers and methods of making and using
NL2023066B1 (en) * 2019-05-03 2020-11-30 Curesupport Holding B V Stabilized liposomes
US12023394B2 (en) * 2020-05-05 2024-07-02 The Regents Of The University Of California Vesicle-coated fibers made from crosslinked lipids
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
DE69014885T2 (de) * 1989-06-22 1995-04-27 Vestar Inc Einkapselverfahren.

Also Published As

Publication number Publication date
DE69113640D1 (de) 1995-11-09
EP0592446A1 (en) 1994-04-20
ATE128621T1 (de) 1995-10-15
GR3017836T3 (en) 1996-01-31
CA2111593A1 (en) 1993-01-21
AU654835B2 (en) 1994-11-24
WO1993000888A1 (en) 1993-01-21
EP0592446B1 (en) 1995-10-04
DE69113640T2 (de) 1996-03-07
AU9178091A (en) 1993-02-11
JPH06511470A (ja) 1994-12-22
DK0592446T3 (da) 1996-01-29

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