ES2076894B1 - Derivados de 2-(4-(4-azolilbutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos. - Google Patents
Derivados de 2-(4-(4-azolilbutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos.Info
- Publication number
- ES2076894B1 ES2076894B1 ES09400191A ES9400191A ES2076894B1 ES 2076894 B1 ES2076894 B1 ES 2076894B1 ES 09400191 A ES09400191 A ES 09400191A ES 9400191 A ES9400191 A ES 9400191A ES 2076894 B1 ES2076894 B1 ES 2076894B1
- Authority
- ES
- Spain
- Prior art keywords
- azolylbutyl
- preparation
- application
- derivatives
- piperacinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS DE 2-[4-(4-AZOLILBUTIL)-1-PIPERACINIL]-5-HIDROXIPIRIMIDINA, SU PREPARACION Y SU APLICACION COMO MEDICAMENTOS. DERIVADOS DE 2-[4-(4-AZOLILBUTIL)-1-PIPERACINIL]-5-HIDROXIPIRIMIDINA, CARACTERIZADOS POR EL HECHO DE QUE RESPONDEN A LA FORMULA GENERAL I, EN LA QUE X2 REPRESENTA UN ATOMO DE NITROGENO O UN GRUPO C-R2, X4 REPRESENTA UN ATOMO DE NITROGENO O UN GRUPO C-R4, X5 REPRESENTA UN ATOMO DE NITROGENO O UN GRUPO C-R5, SU PROCEDIMIENTO DE PREPARACION, SU APLICACION COMO MEDICAMENTO, ASI COMO LAS COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDAN. PRESENTAN UNA ACTIVIDAD BIOLOGICA SOBRE EL SISTEMA NERVIOSO CENTRAL, EN PARTICULAR ANSIOLITICA Y TRANQUILIZANTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9301293A FR2701260B1 (fr) | 1993-02-05 | 1993-02-05 | Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2076894A1 ES2076894A1 (es) | 1995-11-01 |
ES2076894B1 true ES2076894B1 (es) | 1996-10-16 |
Family
ID=9443776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09400191A Expired - Fee Related ES2076894B1 (es) | 1993-02-05 | 1994-02-03 | Derivados de 2-(4-(4-azolilbutil)-1-piperacinil)-5-hidroxipirimidina, su preparacion y su aplicacion como medicamentos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5444059A (es) |
EP (1) | EP0610140B1 (es) |
JP (1) | JPH06234762A (es) |
KR (1) | KR940019705A (es) |
AT (1) | ATE188693T1 (es) |
AU (1) | AU684479B2 (es) |
BR (1) | BR1100847A (es) |
CA (1) | CA2115016A1 (es) |
DE (1) | DE69422532D1 (es) |
ES (1) | ES2076894B1 (es) |
FR (1) | FR2701260B1 (es) |
HU (1) | HU218211B (es) |
NO (1) | NO305082B1 (es) |
RU (1) | RU2118318C1 (es) |
ZA (1) | ZA94775B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
US5633377A (en) * | 1990-12-28 | 1997-05-27 | Neurogen Corporation | 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands |
US5773616A (en) * | 1995-02-15 | 1998-06-30 | Neurogen Corporation | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands |
US6011052A (en) * | 1996-04-30 | 2000-01-04 | Warner-Lambert Company | Pyrazolone derivatives as MCP-1 antagonists |
US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
DE19951960C2 (de) * | 1999-10-28 | 2002-06-27 | Gruenenthal Gmbh | Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate |
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
KR100465649B1 (ko) * | 2002-09-17 | 2005-01-13 | 한국포리올 주식회사 | 일체형 연마 패드 및 그 제조 방법 |
ATE532772T1 (de) * | 2003-07-30 | 2011-11-15 | Xenon Pharmaceuticals Inc | Piperazinderivate und deren verwendung als therapeutische mittel |
WO2011030139A1 (en) | 2009-09-11 | 2011-03-17 | Astrazeneca Ab | 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4423049A (en) * | 1981-12-28 | 1983-12-27 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
US5187276A (en) * | 1983-06-18 | 1993-02-16 | Troponwerke Gmbh & Co. Kg. | 2-pyrimidinyl-1-piperazine derivatives |
FR2642759B1 (fr) * | 1989-02-09 | 1991-05-17 | Laboratorios Esteve Sa | Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante |
FR2654621B1 (fr) * | 1989-11-22 | 1994-09-23 | Esteve Labor Dr | Inhibition du syndrome d'abstinence. |
FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
FR2665161B1 (fr) * | 1990-07-26 | 1992-11-27 | Esteve Labor Dr | Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments. |
ZA918221B (en) * | 1990-10-23 | 1992-06-24 | Akzo Nv | 4-(4-or 6-(trifluoromethyl-2-pyridinyl))-1-piperazinyl-alkyl substituted lactams |
FR2671972B1 (fr) * | 1991-01-25 | 1995-03-03 | Esteve Labor Dr | Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives. |
FR2673628B1 (fr) * | 1991-03-07 | 1993-07-09 | Esteve Labor Dr | Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles. |
FR2705098B1 (fr) * | 1993-05-10 | 1995-08-04 | Esteve Labor Dr | Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) . |
-
1993
- 1993-02-05 FR FR9301293A patent/FR2701260B1/fr not_active Expired - Fee Related
-
1994
- 1994-01-26 NO NO940274A patent/NO305082B1/no unknown
- 1994-02-03 KR KR1019940001980A patent/KR940019705A/ko not_active IP Right Cessation
- 1994-02-03 ES ES09400191A patent/ES2076894B1/es not_active Expired - Fee Related
- 1994-02-04 CA CA002115016A patent/CA2115016A1/fr not_active Abandoned
- 1994-02-04 DE DE69422532T patent/DE69422532D1/de not_active Expired - Lifetime
- 1994-02-04 HU HU9400321A patent/HU218211B/hu not_active IP Right Cessation
- 1994-02-04 EP EP94400238A patent/EP0610140B1/fr not_active Expired - Lifetime
- 1994-02-04 AU AU54889/94A patent/AU684479B2/en not_active Ceased
- 1994-02-04 ZA ZA94775A patent/ZA94775B/xx unknown
- 1994-02-04 US US08/192,142 patent/US5444059A/en not_active Expired - Fee Related
- 1994-02-04 JP JP6012842A patent/JPH06234762A/ja active Pending
- 1994-02-04 AT AT94400238T patent/ATE188693T1/de active
- 1994-02-04 RU RU94003397A patent/RU2118318C1/ru active
-
1997
- 1997-05-12 BR BR1100847-4A patent/BR1100847A/pt active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ES2076894A1 (es) | 1995-11-01 |
JPH06234762A (ja) | 1994-08-23 |
KR940019705A (ko) | 1994-09-14 |
FR2701260A1 (fr) | 1994-08-12 |
AU684479B2 (en) | 1997-12-18 |
CA2115016A1 (fr) | 1994-08-06 |
EP0610140A1 (fr) | 1994-08-10 |
ATE188693T1 (de) | 2000-01-15 |
DE69422532D1 (de) | 2000-02-17 |
NO940274L (no) | 1994-08-08 |
AU5488994A (en) | 1994-08-11 |
NO940274D0 (no) | 1994-01-26 |
HU218211B (hu) | 2000-06-28 |
EP0610140B1 (fr) | 2000-01-12 |
BR1100847A (pt) | 1999-12-07 |
ZA94775B (en) | 1994-09-29 |
US5444059A (en) | 1995-08-22 |
FR2701260B1 (fr) | 1995-05-05 |
HU9400321D0 (en) | 1994-05-30 |
HUT70196A (en) | 1995-09-28 |
NO305082B1 (no) | 1999-03-29 |
RU2118318C1 (ru) | 1998-08-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19940203 Kind code of ref document: B1 Effective date: 19940203 |
|
FD1A | Patent lapsed |
Effective date: 20020401 |