ES2075849T3 - Derivados heterociclicos. - Google Patents

Derivados heterociclicos.

Info

Publication number
ES2075849T3
ES2075849T3 ES89302486T ES89302486T ES2075849T3 ES 2075849 T3 ES2075849 T3 ES 2075849T3 ES 89302486 T ES89302486 T ES 89302486T ES 89302486 T ES89302486 T ES 89302486T ES 2075849 T3 ES2075849 T3 ES 2075849T3
Authority
ES
Spain
Prior art keywords
group
hydrogen
alkyl
hetero
het
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89302486T
Other languages
English (en)
Inventor
Vittorio Vecchietti
Giuseppe Giardina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
Smithkline Beecham Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888806210A external-priority patent/GB8806210D0/en
Priority claimed from GB888823562A external-priority patent/GB8823562D0/en
Application filed by Smithkline Beecham Farmaceutici SpA filed Critical Smithkline Beecham Farmaceutici SpA
Application granted granted Critical
Publication of ES2075849T3 publication Critical patent/ES2075849T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/42—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having etherified hydroxy groups and at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UN COMPUESTO O UN SOLVATO O SAL DE ESTO, DE FORMULA(I), DONDE RCO - ES UN GRUPO ACILO CONTENIENDO UN GRUPO AROMATICO HETEROCICLICO O AROMATICO CARBOXILICO NO SUSTITUIDO O SUSTITUIDO; R1 Y R2 SON INDEPENDIENTEMENTE H, C1 - C6 ALQUILO, C2 - C6 ALQUENILO, C3 - C6 CICLOALQUILO O C4 - C12 CICLOALQUILALQUILO O JUNTOS FORMAN UN POLIMETILENO LINEAL O RAMIFICADO C3 - 8 O UN GRUPO ALQUENILENO C1 6, OPCIONALMENTE SUSTITUIDO CON UN HETEROATOMO; R3 ES H, C1 - 6 ALQUILO O FENILO O R3 JUNTO CON R1 FORMA UN GRUPO - (CH2)3 - O (CH2)4, R4 ES C1 - 6 ALQUILO O FENILO R5 ES H O JUNTO CON R4 FORMA UN GRUPO - (CH2)N - EN EL QUE N ES 1, 2 O 3 Y HET ES UN GRUPO HETEROCICLICO DE ANILLO UNICO O FUSIONADO OPCIONALMENTE SUSTITUIDO, CONTENIENDO DE 5 A 12 ATOMOS DE ANILLO Y COMPRENDIENDO HASTA 4 HETEROATOMOS EN EL ANILLO SELECCIONADO DE O, N Y S CON LA CONDICION DE QUE CUANDO, SUMULTANEAMENTE, R1 Y R2 JUNTOS SON BUTILENO LINEAL, R3 ES H, R4 ES METILO, R5 ES H Y R ES 3,4 - DICLOROFENILO, HET NO ES PIRIDILO, ES UTIL PARA EL TRATAMIENTO DEL DOLOR.
ES89302486T 1988-03-16 1989-03-14 Derivados heterociclicos. Expired - Lifetime ES2075849T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888806210A GB8806210D0 (en) 1988-03-16 1988-03-16 Novel compounds
GB888823562A GB8823562D0 (en) 1988-10-07 1988-10-07 Novel compounds

Publications (1)

Publication Number Publication Date
ES2075849T3 true ES2075849T3 (es) 1995-10-16

Family

ID=26293641

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89302486T Expired - Lifetime ES2075849T3 (es) 1988-03-16 1989-03-14 Derivados heterociclicos.

Country Status (14)

Country Link
US (1) US4999359A (es)
EP (1) EP0333427B1 (es)
JP (1) JPH02101062A (es)
KR (1) KR890014478A (es)
AT (1) ATE126802T1 (es)
AU (1) AU616488B2 (es)
CA (1) CA1336909C (es)
DE (1) DE68923891T2 (es)
DK (1) DK124089A (es)
ES (1) ES2075849T3 (es)
GR (1) GR3017213T3 (es)
IE (1) IE67334B1 (es)
NZ (1) NZ228331A (es)
PT (1) PT90001B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8824400D0 (en) * 1988-10-18 1988-11-23 Glaxo Group Ltd Chemical compounds
GB8827479D0 (en) * 1988-11-24 1988-12-29 Zambeletti Spa L Novel compounds
DE3935371A1 (de) * 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen
GB8926560D0 (en) * 1989-11-24 1990-01-17 Zambeletti Spa L Pharmaceuticals
ATE148463T1 (de) * 1989-11-24 1997-02-15 Smithkline Beecham Spa N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel
EP0594611A1 (en) * 1990-04-28 1994-05-04 Dr. Lo. Zambeletti S.p.A. Novel 1-(2h-1-oxo-3,4-dihydronaphtyl-6)-acetyl-piperidines, process for their preparation and therapeutic use
GB9104839D0 (en) * 1991-03-07 1991-04-17 Zambeletti Spa L Novel compounds
WO1992018115A1 (en) * 1991-04-18 1992-10-29 Dr Lo Zambeletti S.P.A. Use of heterocyclic compounds for the treatment of inflammatory pain
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
JP2003526594A (ja) * 1997-07-14 2003-09-09 アドラー コーポレーション カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
AU2001216218A1 (en) 2000-05-25 2001-12-11 Sepracor, Inc. Heterocyclic analgesic compounds and method of use thereof
US6476046B1 (en) 2000-12-04 2002-11-05 Sepracor, Inc. Diazabicyclo[4.3.0]nonanes, and methods of use thereof
CL2007002097A1 (es) 2006-07-20 2008-01-18 Smithkline Beecham Corp Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras.
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
PE20120003A1 (es) 2009-01-30 2012-02-12 Glaxosmithkline Llc Hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil)etil}-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino
AU2010325925B2 (en) 2009-12-04 2016-02-25 Pgi Drug Discovery Llc. Multicyclic compounds and methods of use thereof
JP2019523279A (ja) 2016-07-29 2019-08-22 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 化合物および組成物ならびにそれらの使用
MA45857A (fr) 2016-07-29 2021-05-19 Sunovion Pharmaceuticals Inc Composés et compositions, et utilisations associées
JP7177053B2 (ja) * 2016-12-02 2022-11-22 フラウンホファー ゲセルシャフト ツール フェールデルンク ダー アンゲヴァンテン フォルシュンク エー．ファオ． 歯周炎の治療に使用するための細菌グルタミニルシクラーゼ及びその阻害剤
AU2018220509B2 (en) 2017-02-16 2022-04-28 Sunovion Pharmaceuticials Inc. Methods of treating schizophrenia
CA3070993A1 (en) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. Isochroman compounds and uses thereof
KR20200122345A (ko) 2018-02-16 2020-10-27 선오비온 파마슈티컬스 인코포레이티드 염, 결정 형태 및 이들의 제조 방법
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
CA3180115A1 (en) 2020-04-14 2021-10-21 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
GB8618188D0 (en) * 1986-07-25 1986-09-03 Ici Plc Diamine compounds
DE3766335D1 (de) * 1986-09-17 1991-01-03 Zambeletti Spa L N-1-acylierte-(1-(phenyl- oder benzyl-))-1,2-aethylendiamine.
DE3935371A1 (de) * 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen

Also Published As

Publication number Publication date
CA1336909C (en) 1995-09-05
NZ228331A (en) 1991-10-25
US4999359A (en) 1991-03-12
KR890014478A (ko) 1989-10-23
DE68923891D1 (de) 1995-09-28
JPH02101062A (ja) 1990-04-12
PT90001A (pt) 1989-11-10
PT90001B (pt) 1994-06-30
AU616488B2 (en) 1991-10-31
IE890816L (en) 1989-09-16
AU3131589A (en) 1989-09-21
EP0333427A1 (en) 1989-09-20
DK124089A (da) 1989-09-17
EP0333427B1 (en) 1995-08-23
DE68923891T2 (de) 1996-02-22
ATE126802T1 (de) 1995-09-15
GR3017213T3 (en) 1995-11-30
IE67334B1 (en) 1996-03-20
DK124089D0 (da) 1989-03-14

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