ES2075797A1 - Therapeutically active hydroxamic acid derivatives, process for their preparation, pharmaceutical compositions containing them and use of the said compounds in medicine - Google Patents

Therapeutically active hydroxamic acid derivatives, process for their preparation, pharmaceutical compositions containing them and use of the said compounds in medicine

Info

Publication number
ES2075797A1
ES2075797A1 ES09301818A ES9301818A ES2075797A1 ES 2075797 A1 ES2075797 A1 ES 2075797A1 ES 09301818 A ES09301818 A ES 09301818A ES 9301818 A ES9301818 A ES 9301818A ES 2075797 A1 ES2075797 A1 ES 2075797A1
Authority
ES
Spain
Prior art keywords
compounds
medicine
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301818A
Other languages
Spanish (es)
Other versions
ES2075797B1 (en
Inventor
Jonathon Philip Dickens
Raymond John Crimmin
Raymond Paul Beckett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Bio Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology Ltd filed Critical British Bio Technology Ltd
Priority to ES9301818A priority Critical patent/ES2075797B1/en
Publication of ES2075797A1 publication Critical patent/ES2075797A1/en
Application granted granted Critical
Publication of ES2075797B1 publication Critical patent/ES2075797B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them and use of the said compounds in medicine. This invention relates to therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them and use of the said compounds in medicine, specifically compounds of formula (I) in which: R2 is an R6-A- group where A is a saturated or unsaturated, straight or branched divalent hydrocarbon chain, R3 is an R7-(Bn)- group where n is 0 or 1, B is a saturated or unsaturated, straight or branched divalent hydrocarbon chain, R4 is hydrogen or methyl, R5 is hydrogen, or an alkyl or amino group or R3 and R5 taken together are a divalent hydrocarbon chain. These compounds inhibit the action of metal proteinases and are useful for the treatment or prophylaxis of conditions which give rise to tissue disintegration.
ES9301818A 1993-08-18 1993-08-18 DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE. Expired - Fee Related ES2075797B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301818A ES2075797B1 (en) 1993-08-18 1993-08-18 DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301818A ES2075797B1 (en) 1993-08-18 1993-08-18 DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.

Publications (2)

Publication Number Publication Date
ES2075797A1 true ES2075797A1 (en) 1995-10-01
ES2075797B1 ES2075797B1 (en) 1996-05-16

Family

ID=8282876

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301818A Expired - Fee Related ES2075797B1 (en) 1993-08-18 1993-08-18 DERIVATIVES OF THERAPEUTICALLY ACTIVE HYDROXAMIC ACIDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THE USE OF SUCH COMPOUNDS IN MEDICINE.

Country Status (1)

Country Link
ES (1) ES2075797B1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002716A2 (en) * 1989-08-24 1991-03-07 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
WO1994002447A1 (en) * 1992-07-23 1994-02-03 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as metalloproteinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002716A2 (en) * 1989-08-24 1991-03-07 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
WO1994002447A1 (en) * 1992-07-23 1994-02-03 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as metalloproteinase inhibitors

Also Published As

Publication number Publication date
ES2075797B1 (en) 1996-05-16

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Legal Events

Date Code Title Description
PC2A Transfer of patent

Owner name: BRITISH BIOTECH PHARMACEUTICALS LIMITED

FD1A Patent lapsed

Effective date: 20100528