ES2075402T3 - Conjugados quelados con metales paramagneticos para enfoque deliberado. - Google Patents

Conjugados quelados con metales paramagneticos para enfoque deliberado.

Info

Publication number
ES2075402T3
ES2075402T3 ES91810589T ES91810589T ES2075402T3 ES 2075402 T3 ES2075402 T3 ES 2075402T3 ES 91810589 T ES91810589 T ES 91810589T ES 91810589 T ES91810589 T ES 91810589T ES 2075402 T3 ES2075402 T3 ES 2075402T3
Authority
ES
Spain
Prior art keywords
chelated
conjugates
paramagnetic metals
bond
chelatant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91810589T
Other languages
English (en)
Inventor
Paul Palacios
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of ES2075402T3 publication Critical patent/ES2075402T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Measurement Of Force In General (AREA)
  • Aerodynamic Tests, Hydrodynamic Tests, Wind Tunnels, And Water Tanks (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

EN ESTE METODO, SE UNE UNA O MAS MOLECULAS QUELATANTES A UN COMPUESTO INTERMEDIO DE MONOZA TEMPORALMENTE SOBRE UNA FASE SOLIDA MEDIANTE UNA UNION SEPARABLE. POSTERIORMENTE, SE SEPARA DICHA UNION PARA LIBERAR LA MOLECULA DESEADA DEL CONJUGADO, MEDIANTE LO QUE SE GENERA UNA ZONA REACTIVA EN LA ZONA DE LA SEPARACION. EL CONJUGADO PUEDE ACOPLARSE A UN FACTOR ALBERGANTE DE LA PROTEINA USANDO DICHA ZONA REACTIVA; ESTA ULTIMA SERA SIMPLE POR CADA MOLECULA QUELATANTE. DE ESTA MANERA SE EVITAN LOS ENLACES NO DESEADOS DURANTE LA CONJUGACION.
ES91810589T 1991-07-22 1991-07-22 Conjugados quelados con metales paramagneticos para enfoque deliberado. Expired - Lifetime ES2075402T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91810589A EP0529175B1 (en) 1991-07-22 1991-07-22 Conjugates chelated with paramagnetic metals for targetting

Publications (1)

Publication Number Publication Date
ES2075402T3 true ES2075402T3 (es) 1995-10-01

Family

ID=8208865

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91810589T Expired - Lifetime ES2075402T3 (es) 1991-07-22 1991-07-22 Conjugados quelados con metales paramagneticos para enfoque deliberado.

Country Status (16)

Country Link
US (2) US5414114A (es)
EP (1) EP0529175B1 (es)
JP (1) JP3463810B2 (es)
KR (1) KR100191563B1 (es)
AT (1) ATE126066T1 (es)
AU (1) AU664192B2 (es)
CA (1) CA2090033C (es)
DE (2) DE69112053D1 (es)
DK (1) DK0529175T3 (es)
ES (1) ES2075402T3 (es)
FI (1) FI931070A (es)
GR (1) GR3017326T3 (es)
HU (1) HUT63344A (es)
IE (1) IE68854B1 (es)
NO (1) NO305464B1 (es)
WO (1) WO1993001837A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
US6962686B2 (en) 1994-10-12 2005-11-08 California Institute Of Technology Cell-specific gene delivery vehicles
US6232295B1 (en) 1994-10-12 2001-05-15 Jon Faiz Kayyem Cell-specific contrast agent and gene delivery vehicles
US7317070B1 (en) * 2004-03-12 2008-01-08 Sigma-Aldrich Co. Process for the preparation of polyamino acids
US7205385B2 (en) * 2004-11-12 2007-04-17 General Electric Company Polymerization method for the synthesis of polypeptide imaging agents
US8455255B2 (en) * 2006-06-08 2013-06-04 The University Of Tokushima Method for production of novel nano silica particle and use of the nano silica particle
PL2307448T3 (pl) * 2008-08-07 2015-10-30 Sigma Aldrich Co Llc Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040506B1 (en) * 1980-05-21 1986-08-20 Teijin Limited Reactive polymer and process for the preparation thereof
FR2586813B1 (fr) * 1985-08-30 1989-05-12 Inst Nat Sante Rech Med Supports proteiques modifies aptes a immobiliser de facon reversible des anticorps ou des substances immunologiquement actives, et leurs applications au dosage et a la purification d'antigenes ou similaires.
IN165717B (es) * 1986-08-07 1989-12-23 Battelle Memorial Institute
JPH01126555A (ja) * 1987-11-11 1989-05-18 Meidensha Corp 免疫測定用試薬

Also Published As

Publication number Publication date
NO305464B1 (no) 1999-06-07
FI931070A0 (fi) 1993-03-10
DE69112053D1 (de) 1995-09-14
NO930894D0 (no) 1993-03-11
GR3017326T3 (en) 1995-12-31
JPH06502192A (ja) 1994-03-10
AU2274192A (en) 1993-02-23
EP0529175A1 (en) 1993-03-03
DE69112053T2 (de) 1996-05-02
HU9300802D0 (en) 1993-06-28
EP0529175B1 (en) 1995-08-09
AU664192B2 (en) 1995-11-09
IE68854B1 (en) 1996-07-24
ATE126066T1 (de) 1995-08-15
DK0529175T3 (da) 1995-11-06
HUT63344A (en) 1993-08-30
CA2090033C (en) 2000-05-16
US5414114A (en) 1995-05-09
NO930894L (no) 1993-03-11
FI931070A (fi) 1993-03-10
KR100191563B1 (ko) 1999-06-15
KR930701174A (ko) 1993-06-11
WO1993001837A1 (en) 1993-02-04
DE69112053T4 (de) 1996-08-22
US5571940A (en) 1996-11-05
IE922362A1 (en) 1993-01-27
JP3463810B2 (ja) 2003-11-05
CA2090033A1 (en) 1993-01-23

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