ES2074950A1 - Viral vaccine for the prevention of porcine reproductive and respiratory syndrome - Google Patents

Viral vaccine for the prevention of porcine reproductive and respiratory syndrome

Info

Publication number
ES2074950A1
ES2074950A1 ES9301973A ES9301973A ES2074950A1 ES 2074950 A1 ES2074950 A1 ES 2074950A1 ES 9301973 A ES9301973 A ES 9301973A ES 9301973 A ES9301973 A ES 9301973A ES 2074950 A1 ES2074950 A1 ES 2074950A1
Authority
ES
Spain
Prior art keywords
vaccine
respiratory syndrome
porcine reproductive
prrs
prevention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9301973A
Other languages
Spanish (es)
Other versions
ES2074950B1 (en
Inventor
Duran Juan Plana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoetis Belgium SA
Original Assignee
Cyanamid Iberica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyanamid Iberica SA filed Critical Cyanamid Iberica SA
Priority to ES9301973A priority Critical patent/ES2074950B1/en
Priority to NL9401414A priority patent/NL194940C/en
Priority to DK199401028A priority patent/DK173128B1/en
Priority to FR9410722A priority patent/FR2709966B1/en
Priority to ITTO940713 priority patent/IT1267448B1/en
Priority to DE19944432338 priority patent/DE4432338C2/en
Priority to GB9418775A priority patent/GB2282811B/en
Publication of ES2074950A1 publication Critical patent/ES2074950A1/en
Application granted granted Critical
Publication of ES2074950B1 publication Critical patent/ES2074950B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10051—Methods of production or purification of viral material
    • C12N2770/10052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A virus has been isolated, capable of reproducing in sows the reproductive alterations associated with porcine reproductive and respiratory syndrome (PRRS) and in piglets, respiratory disorders, which may be used in the formulation of a vaccine capable of protecting sows against PRRS. A vaccine is described which contains a suitable quantity of viral antigen, inactivated, as well as a suitable adjuvant. The vaccine has proven to be efficacious in experiments of challenge with PRRS viruses different from the described Spanish strain. DNA sequences of Open Reading Frames 3 to 7 of the isolated virus, together with the corresponding amino acid sequences, are disclosed.
ES9301973A 1993-09-17 1993-09-17 VACCINE FOR THE PREVENTION OF REPRODUCTIVE AND RESPIRATORY DISEASE OF THE SOW. Expired - Fee Related ES2074950B1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES9301973A ES2074950B1 (en) 1993-09-17 1993-09-17 VACCINE FOR THE PREVENTION OF REPRODUCTIVE AND RESPIRATORY DISEASE OF THE SOW.
NL9401414A NL194940C (en) 1993-09-17 1994-08-31 Virus strain and vaccine to prevent pig reproduction and respiration syndrome.
DK199401028A DK173128B1 (en) 1993-09-17 1994-09-06 Vaccine against the porcine reproductive and respiratory syndrome method for its preparation, as well as a virus and a DNA
FR9410722A FR2709966B1 (en) 1993-09-17 1994-09-07 Vaccine for the prevention of respiratory syndrome and pig reproduction.
ITTO940713 IT1267448B1 (en) 1993-09-17 1994-09-09 VACCINE FOR THE PREVENTION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME.
DE19944432338 DE4432338C2 (en) 1993-09-17 1994-09-10 Vaccine to prevent reproductive and respiratory syndrome in pigs
GB9418775A GB2282811B (en) 1993-09-17 1994-09-16 Vaccine for the prevention of porcine reproductive and respiratory syndrome

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301973A ES2074950B1 (en) 1993-09-17 1993-09-17 VACCINE FOR THE PREVENTION OF REPRODUCTIVE AND RESPIRATORY DISEASE OF THE SOW.

Publications (2)

Publication Number Publication Date
ES2074950A1 true ES2074950A1 (en) 1995-09-16
ES2074950B1 ES2074950B1 (en) 1996-03-16

Family

ID=8283072

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301973A Expired - Fee Related ES2074950B1 (en) 1993-09-17 1993-09-17 VACCINE FOR THE PREVENTION OF REPRODUCTIVE AND RESPIRATORY DISEASE OF THE SOW.

Country Status (7)

Country Link
DE (1) DE4432338C2 (en)
DK (1) DK173128B1 (en)
ES (1) ES2074950B1 (en)
FR (1) FR2709966B1 (en)
GB (1) GB2282811B (en)
IT (1) IT1267448B1 (en)
NL (1) NL194940C (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2078187A1 (en) * 1994-05-13 1995-12-01 Cynamid Iberica S A Recombinant PRRS proteins, diagnostic kits and vaccines containing said recombinant proteins
WO2013152086A1 (en) 2012-04-04 2013-10-10 Zoetis Llc Pcv/mycoplasma hyopneumoniae/prrs combination vaccine
EP3508218A1 (en) 2012-04-04 2019-07-10 Zoetis Services LLC Pcv/mycoplasma hyopneumoniae combination vaccine
EP4039271A1 (en) 2012-04-04 2022-08-10 Zoetis Services LLC Mycoplasma hyopneumoniae vaccine

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69201441T3 (en) * 1991-06-06 2008-12-04 Boehringer Ingelheim Vetmedica Gmbh ENTIRE MYSTERIOUS POVERTY, VACCINE COMPOSITIONS AND DIAGNOSIS KITS.
US6042830A (en) * 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US6773908B1 (en) 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US6251397B1 (en) 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
US6380376B1 (en) 1992-10-30 2002-04-30 Iowa State University Research Foundation Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
GB2289279B (en) * 1994-05-13 1998-09-16 Iberica Cyanamid Diagnostic kits and vaccines containing recombinant PRRSV proteins
US5866401A (en) * 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
MY115070A (en) * 1996-03-01 2003-03-31 Schering Corp Porcine reproductive and respiratory syndrome vaccine
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
CA2703181C (en) 1997-05-06 2016-06-28 Boehringer Ingelheim Vetmedica Gmbh Prrsv antigenic sites identifying peptide sequences of prrs virus for use in vaccines or diagnostic assays
UA78180C2 (en) 1997-10-03 2007-03-15 Меріаль Porcine circovirus, vaccines and diagnostic reagents
CA2440933A1 (en) 1998-12-22 2000-06-22 Pfizer Products Inc. An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof
CA2366072C (en) 1999-03-08 2007-07-10 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Prrsv vaccines
AU4482200A (en) 1999-04-22 2000-11-10 United States Department Of Agriculture Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142
CA2571452A1 (en) 2004-06-18 2006-01-26 Regents Of The University Of Minnesota Identifying virally infected and vaccinated organisms
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
PL2460820T3 (en) 2004-12-30 2019-09-30 Boehringer Ingelheim Animal Health USA Inc. Pcv2 immunogenic compositions and methods of producing such compositions
UA95778C2 (en) 2005-06-24 2011-09-12 Риджентс Оф Зе Юниверсити Оф Миннесота Prrs viruses, infectious clones, mutants thereof, and methods of use
RU2488407C2 (en) 2005-12-29 2013-07-27 Берингер Ингельхайм Ветмедика, Инк. Polyvalent immunogenic compositions pcv2 and methods for producing such compositions
TWI627281B (en) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 Methods of reducing viricidal activity in pcv-2 compositions and pcv-2 compositions with an improved immunogenicity
EP2558118B1 (en) * 2010-04-16 2019-06-05 Universiteit Gent Cross-protecting vaccine for porcine reproductive and respiratory syndrome virus
JP2014506795A (en) 2011-02-17 2014-03-20 ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング PRRSV industrial scale manufacturing method
PL2959916T3 (en) 2011-02-17 2019-05-31 Boehringer Ingelheim Vetmedica Gmbh Novel european prrsv strain
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
EP2737059A1 (en) 2011-07-29 2014-06-04 Boehringer Ingelheim Vetmedica GmbH Novel prrs virus inducing type i interferon in susceptible cells
US9579373B2 (en) 2013-03-15 2017-02-28 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
CN105829528B (en) 2013-12-20 2019-10-22 勃林格殷格翰动物保健有限公司 PRRS viral variants, European PRRS virus cDNA clone and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992021375A1 (en) * 1991-06-06 1992-12-10 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE131067T1 (en) * 1991-10-14 1995-12-15 Akzo Nobel Nv VACCINE AGAINST SWINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) AND DIAGNOSIS.
FR2686097B1 (en) * 1992-01-14 1994-12-30 Rhone Merieux PREPARATION OF ANTIGENS AND MYSTERY DISEASE VIRUS VACCINES, ANTIGENS AND VACCINES OBTAINED FOR THE PREVENTION OF THIS DISEASE.
KR100374295B1 (en) * 1993-02-08 2003-12-24 바이엘 코포레이션 Methods for growing pigs and respiratory syndrome virus and their use in vaccines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992021375A1 (en) * 1991-06-06 1992-12-10 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JANNEKE J.M. MEULENBERG et al. Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV. Virology 1993, Vol. 192, pßginas 62-72 * Todo el documento * *
KARL-KLAUS CONZELMANN et al. Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus groyp. Virology 1993, Vol. 193, pßginas 329-339 * Todo el documento * *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2078187A1 (en) * 1994-05-13 1995-12-01 Cynamid Iberica S A Recombinant PRRS proteins, diagnostic kits and vaccines containing said recombinant proteins
ES2085837A1 (en) * 1994-05-13 1996-06-01 Iberica Cyanamid Recombinant PRRS proteins, diagnostic kits and vaccines containing said recombinant proteins
WO2013152086A1 (en) 2012-04-04 2013-10-10 Zoetis Llc Pcv/mycoplasma hyopneumoniae/prrs combination vaccine
EP3508218A1 (en) 2012-04-04 2019-07-10 Zoetis Services LLC Pcv/mycoplasma hyopneumoniae combination vaccine
EP4039271A1 (en) 2012-04-04 2022-08-10 Zoetis Services LLC Mycoplasma hyopneumoniae vaccine

Also Published As

Publication number Publication date
ITTO940713A1 (en) 1996-03-09
IT1267448B1 (en) 1997-02-05
NL9401414A (en) 1995-04-18
FR2709966B1 (en) 1997-05-23
DK102894A (en) 1995-03-18
FR2709966A1 (en) 1995-03-24
GB9418775D0 (en) 1994-11-02
DK173128B1 (en) 2000-01-31
NL194940C (en) 2003-08-04
GB2282811B (en) 1998-02-18
GB2282811A (en) 1995-04-19
DE4432338C2 (en) 1997-10-30
NL194940B (en) 2003-04-01
ITTO940713A0 (en) 1994-09-09
DE4432338A1 (en) 1995-05-04
ES2074950B1 (en) 1996-03-16

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Legal Events

Date Code Title Description
PC2A Transfer of patent

Owner name: PFIZER ANIMAL HEALTH, S.A.

Effective date: 20121211

FD2A Announcement of lapse in spain

Effective date: 20141120