ES2074950A1 - Viral vaccine for the prevention of porcine reproductive and respiratory syndrome - Google Patents
Viral vaccine for the prevention of porcine reproductive and respiratory syndromeInfo
- Publication number
- ES2074950A1 ES2074950A1 ES9301973A ES9301973A ES2074950A1 ES 2074950 A1 ES2074950 A1 ES 2074950A1 ES 9301973 A ES9301973 A ES 9301973A ES 9301973 A ES9301973 A ES 9301973A ES 2074950 A1 ES2074950 A1 ES 2074950A1
- Authority
- ES
- Spain
- Prior art keywords
- vaccine
- respiratory syndrome
- porcine reproductive
- prrs
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 title abstract 5
- 230000002265 prevention Effects 0.000 title 1
- 229960004854 viral vaccine Drugs 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 3
- 229960005486 vaccine Drugs 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001850 reproductive effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10051—Methods of production or purification of viral material
- C12N2770/10052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
A virus has been isolated, capable of reproducing in sows the reproductive alterations associated with porcine reproductive and respiratory syndrome (PRRS) and in piglets, respiratory disorders, which may be used in the formulation of a vaccine capable of protecting sows against PRRS. A vaccine is described which contains a suitable quantity of viral antigen, inactivated, as well as a suitable adjuvant. The vaccine has proven to be efficacious in experiments of challenge with PRRS viruses different from the described Spanish strain. DNA sequences of Open Reading Frames 3 to 7 of the isolated virus, together with the corresponding amino acid sequences, are disclosed.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301973A ES2074950B1 (en) | 1993-09-17 | 1993-09-17 | VACCINE FOR THE PREVENTION OF REPRODUCTIVE AND RESPIRATORY DISEASE OF THE SOW. |
NL9401414A NL194940C (en) | 1993-09-17 | 1994-08-31 | Virus strain and vaccine to prevent pig reproduction and respiration syndrome. |
DK199401028A DK173128B1 (en) | 1993-09-17 | 1994-09-06 | Vaccine against the porcine reproductive and respiratory syndrome method for its preparation, as well as a virus and a DNA |
FR9410722A FR2709966B1 (en) | 1993-09-17 | 1994-09-07 | Vaccine for the prevention of respiratory syndrome and pig reproduction. |
ITTO940713 IT1267448B1 (en) | 1993-09-17 | 1994-09-09 | VACCINE FOR THE PREVENTION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME. |
DE19944432338 DE4432338C2 (en) | 1993-09-17 | 1994-09-10 | Vaccine to prevent reproductive and respiratory syndrome in pigs |
GB9418775A GB2282811B (en) | 1993-09-17 | 1994-09-16 | Vaccine for the prevention of porcine reproductive and respiratory syndrome |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301973A ES2074950B1 (en) | 1993-09-17 | 1993-09-17 | VACCINE FOR THE PREVENTION OF REPRODUCTIVE AND RESPIRATORY DISEASE OF THE SOW. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2074950A1 true ES2074950A1 (en) | 1995-09-16 |
ES2074950B1 ES2074950B1 (en) | 1996-03-16 |
Family
ID=8283072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9301973A Expired - Fee Related ES2074950B1 (en) | 1993-09-17 | 1993-09-17 | VACCINE FOR THE PREVENTION OF REPRODUCTIVE AND RESPIRATORY DISEASE OF THE SOW. |
Country Status (7)
Country | Link |
---|---|
DE (1) | DE4432338C2 (en) |
DK (1) | DK173128B1 (en) |
ES (1) | ES2074950B1 (en) |
FR (1) | FR2709966B1 (en) |
GB (1) | GB2282811B (en) |
IT (1) | IT1267448B1 (en) |
NL (1) | NL194940C (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2078187A1 (en) * | 1994-05-13 | 1995-12-01 | Cynamid Iberica S A | Recombinant PRRS proteins, diagnostic kits and vaccines containing said recombinant proteins |
WO2013152086A1 (en) | 2012-04-04 | 2013-10-10 | Zoetis Llc | Pcv/mycoplasma hyopneumoniae/prrs combination vaccine |
EP3508218A1 (en) | 2012-04-04 | 2019-07-10 | Zoetis Services LLC | Pcv/mycoplasma hyopneumoniae combination vaccine |
EP4039271A1 (en) | 2012-04-04 | 2022-08-10 | Zoetis Services LLC | Mycoplasma hyopneumoniae vaccine |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69201441T3 (en) * | 1991-06-06 | 2008-12-04 | Boehringer Ingelheim Vetmedica Gmbh | ENTIRE MYSTERIOUS POVERTY, VACCINE COMPOSITIONS AND DIAGNOSIS KITS. |
US6042830A (en) * | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
US6773908B1 (en) | 1992-10-30 | 2004-08-10 | Iowa State University Research Foundation, Inc. | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) |
US5695766A (en) | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
US6592873B1 (en) | 1992-10-30 | 2003-07-15 | Iowa State University Research Foundation, Inc. | Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids |
US6251397B1 (en) | 1992-10-30 | 2001-06-26 | Iowa State University Research Foundation, Inc. | Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same |
US6380376B1 (en) | 1992-10-30 | 2002-04-30 | Iowa State University Research Foundation | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) |
GB2289279B (en) * | 1994-05-13 | 1998-09-16 | Iberica Cyanamid | Diagnostic kits and vaccines containing recombinant PRRSV proteins |
US5866401A (en) * | 1996-03-01 | 1999-02-02 | Schering Corporation | Porcine reproductive and respiratory syndrome vaccine |
MY115070A (en) * | 1996-03-01 | 2003-03-31 | Schering Corp | Porcine reproductive and respiratory syndrome vaccine |
EP0839912A1 (en) | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
CA2703181C (en) | 1997-05-06 | 2016-06-28 | Boehringer Ingelheim Vetmedica Gmbh | Prrsv antigenic sites identifying peptide sequences of prrs virus for use in vaccines or diagnostic assays |
UA78180C2 (en) | 1997-10-03 | 2007-03-15 | Меріаль | Porcine circovirus, vaccines and diagnostic reagents |
CA2440933A1 (en) | 1998-12-22 | 2000-06-22 | Pfizer Products Inc. | An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof |
CA2366072C (en) | 1999-03-08 | 2007-07-10 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Prrsv vaccines |
AU4482200A (en) | 1999-04-22 | 2000-11-10 | United States Department Of Agriculture | Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142 |
CA2571452A1 (en) | 2004-06-18 | 2006-01-26 | Regents Of The University Of Minnesota | Identifying virally infected and vaccinated organisms |
US7632636B2 (en) | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
PL2460820T3 (en) | 2004-12-30 | 2019-09-30 | Boehringer Ingelheim Animal Health USA Inc. | Pcv2 immunogenic compositions and methods of producing such compositions |
UA95778C2 (en) | 2005-06-24 | 2011-09-12 | Риджентс Оф Зе Юниверсити Оф Миннесота | Prrs viruses, infectious clones, mutants thereof, and methods of use |
RU2488407C2 (en) | 2005-12-29 | 2013-07-27 | Берингер Ингельхайм Ветмедика, Инк. | Polyvalent immunogenic compositions pcv2 and methods for producing such compositions |
TWI627281B (en) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | Methods of reducing viricidal activity in pcv-2 compositions and pcv-2 compositions with an improved immunogenicity |
EP2558118B1 (en) * | 2010-04-16 | 2019-06-05 | Universiteit Gent | Cross-protecting vaccine for porcine reproductive and respiratory syndrome virus |
JP2014506795A (en) | 2011-02-17 | 2014-03-20 | ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング | PRRSV industrial scale manufacturing method |
PL2959916T3 (en) | 2011-02-17 | 2019-05-31 | Boehringer Ingelheim Vetmedica Gmbh | Novel european prrsv strain |
US9187731B2 (en) | 2011-07-29 | 2015-11-17 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus inducing type I interferon in susceptible cells |
EP2737059A1 (en) | 2011-07-29 | 2014-06-04 | Boehringer Ingelheim Vetmedica GmbH | Novel prrs virus inducing type i interferon in susceptible cells |
US9579373B2 (en) | 2013-03-15 | 2017-02-28 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use |
CN105829528B (en) | 2013-12-20 | 2019-10-22 | 勃林格殷格翰动物保健有限公司 | PRRS viral variants, European PRRS virus cDNA clone and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992021375A1 (en) * | 1991-06-06 | 1992-12-10 | Stichting Centraal Diergeneeskundig Instituut | Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE131067T1 (en) * | 1991-10-14 | 1995-12-15 | Akzo Nobel Nv | VACCINE AGAINST SWINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) AND DIAGNOSIS. |
FR2686097B1 (en) * | 1992-01-14 | 1994-12-30 | Rhone Merieux | PREPARATION OF ANTIGENS AND MYSTERY DISEASE VIRUS VACCINES, ANTIGENS AND VACCINES OBTAINED FOR THE PREVENTION OF THIS DISEASE. |
KR100374295B1 (en) * | 1993-02-08 | 2003-12-24 | 바이엘 코포레이션 | Methods for growing pigs and respiratory syndrome virus and their use in vaccines |
-
1993
- 1993-09-17 ES ES9301973A patent/ES2074950B1/en not_active Expired - Fee Related
-
1994
- 1994-08-31 NL NL9401414A patent/NL194940C/en not_active IP Right Cessation
- 1994-09-06 DK DK199401028A patent/DK173128B1/en not_active IP Right Cessation
- 1994-09-07 FR FR9410722A patent/FR2709966B1/en not_active Expired - Fee Related
- 1994-09-09 IT ITTO940713 patent/IT1267448B1/en active IP Right Grant
- 1994-09-10 DE DE19944432338 patent/DE4432338C2/en not_active Expired - Lifetime
- 1994-09-16 GB GB9418775A patent/GB2282811B/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992021375A1 (en) * | 1991-06-06 | 1992-12-10 | Stichting Centraal Diergeneeskundig Instituut | Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits |
Non-Patent Citations (2)
Title |
---|
JANNEKE J.M. MEULENBERG et al. Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV. Virology 1993, Vol. 192, pßginas 62-72 * Todo el documento * * |
KARL-KLAUS CONZELMANN et al. Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus groyp. Virology 1993, Vol. 193, pßginas 329-339 * Todo el documento * * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2078187A1 (en) * | 1994-05-13 | 1995-12-01 | Cynamid Iberica S A | Recombinant PRRS proteins, diagnostic kits and vaccines containing said recombinant proteins |
ES2085837A1 (en) * | 1994-05-13 | 1996-06-01 | Iberica Cyanamid | Recombinant PRRS proteins, diagnostic kits and vaccines containing said recombinant proteins |
WO2013152086A1 (en) | 2012-04-04 | 2013-10-10 | Zoetis Llc | Pcv/mycoplasma hyopneumoniae/prrs combination vaccine |
EP3508218A1 (en) | 2012-04-04 | 2019-07-10 | Zoetis Services LLC | Pcv/mycoplasma hyopneumoniae combination vaccine |
EP4039271A1 (en) | 2012-04-04 | 2022-08-10 | Zoetis Services LLC | Mycoplasma hyopneumoniae vaccine |
Also Published As
Publication number | Publication date |
---|---|
ITTO940713A1 (en) | 1996-03-09 |
IT1267448B1 (en) | 1997-02-05 |
NL9401414A (en) | 1995-04-18 |
FR2709966B1 (en) | 1997-05-23 |
DK102894A (en) | 1995-03-18 |
FR2709966A1 (en) | 1995-03-24 |
GB9418775D0 (en) | 1994-11-02 |
DK173128B1 (en) | 2000-01-31 |
NL194940C (en) | 2003-08-04 |
GB2282811B (en) | 1998-02-18 |
GB2282811A (en) | 1995-04-19 |
DE4432338C2 (en) | 1997-10-30 |
NL194940B (en) | 2003-04-01 |
ITTO940713A0 (en) | 1994-09-09 |
DE4432338A1 (en) | 1995-05-04 |
ES2074950B1 (en) | 1996-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer of patent |
Owner name: PFIZER ANIMAL HEALTH, S.A. Effective date: 20121211 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20141120 |