ES2073458T3 - Procedimiento de preparacion de derivados de sales de metales alcalinos del acido 7-amino-cefalosporanico 3,7 sustituido. - Google Patents

Procedimiento de preparacion de derivados de sales de metales alcalinos del acido 7-amino-cefalosporanico 3,7 sustituido.

Info

Publication number
ES2073458T3
ES2073458T3 ES89830042T ES89830042T ES2073458T3 ES 2073458 T3 ES2073458 T3 ES 2073458T3 ES 89830042 T ES89830042 T ES 89830042T ES 89830042 T ES89830042 T ES 89830042T ES 2073458 T3 ES2073458 T3 ES 2073458T3
Authority
ES
Spain
Prior art keywords
acid
salt
cephalosporanic
amino
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89830042T
Other languages
English (en)
Inventor
S K Chang
Q C Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purzer Pharmaceutical Co Ltd
Original Assignee
Purzer Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purzer Pharmaceutical Co Ltd filed Critical Purzer Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2073458T3 publication Critical patent/ES2073458T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNA SAL ALCALINO METALICA DE DERIVADOS DE ACIDO 3,7-SUSTITUIDOS 7-AMINOCEFALOSPORANICO TENIENDO LA FORMULA GENERAL: EN DONDE: O R1= CH3 O C1 M= NA O K Y EL PROCESO PARA PRODUCIR LA SAL DEL DERIVADO DE FORMA ACIDA. EL PROCESO INCLUYE PREPARAR UNA SUSPENSION DE 30% DE PESO DEL DERIVADO DE FORMA ACIDA EN ALCOHOL CONCENTRADO, CONTENIENDO DE 3 A 7% DE PESO DE AGUA Y AÑADIR UNA SOLUCION ALCOHOLICA DE BASE ALCALINA A LA SUSPENSION BAJO TEMPERATURA AMBIENTE. EL ALCOHOL USADO PARA DISOLVER LA BASE TAMBIEN CONTIENE DE 3 A 7% DE AGUA. DESPUES DE UN TIEMPO DE REACCION DE 5 A 20 MINUTOS, SE ENFRIA LA MEZCLA Y SE DEJA CRISTALIZAR LA SAL, Y SE SEPARA LA ULTIMA DE LA FASE LIQUIDA.
ES89830042T 1989-02-06 1989-02-06 Procedimiento de preparacion de derivados de sales de metales alcalinos del acido 7-amino-cefalosporanico 3,7 sustituido. Expired - Lifetime ES2073458T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19890830042 EP0381915B1 (en) 1989-02-06 1989-02-06 Process for preparing alkali metal salts of 3,7-substituted 7-aminocephalosporanic acid derivatives.

Publications (1)

Publication Number Publication Date
ES2073458T3 true ES2073458T3 (es) 1995-08-16

Family

ID=8203202

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89830042T Expired - Lifetime ES2073458T3 (es) 1989-02-06 1989-02-06 Procedimiento de preparacion de derivados de sales de metales alcalinos del acido 7-amino-cefalosporanico 3,7 sustituido.

Country Status (3)

Country Link
EP (1) EP0381915B1 (es)
DE (1) DE68922207T2 (es)
ES (1) ES2073458T3 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100383136B1 (ko) * 2000-12-20 2003-05-12 씨제이 주식회사 7-아미노세팔로스포라닌산의 결정화 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940483A (en) * 1971-02-05 1976-02-24 E. R. Squibb & Sons, Inc. Antibiotic compositions and method
BE792228A (fr) * 1971-12-03 1973-06-01 Bristol Myers Co Agents antibacteriens et procede pour les preparer
US3880842A (en) * 1972-05-30 1975-04-29 Squibb & Sons Inc Cephalosporin derivatives
US3822256A (en) * 1972-06-08 1974-07-02 Bristol Myers Co Crystalline monohydrates of sodium and potassium cephalexin

Also Published As

Publication number Publication date
DE68922207D1 (de) 1995-05-18
EP0381915B1 (en) 1995-04-12
DE68922207T2 (de) 1995-11-09
EP0381915A1 (en) 1990-08-16

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