ES2072607T3 - Derivados 3 indolil tioacetato. - Google Patents

Derivados 3 indolil tioacetato.

Info

Publication number
ES2072607T3
ES2072607T3 ES91907138T ES91907138T ES2072607T3 ES 2072607 T3 ES2072607 T3 ES 2072607T3 ES 91907138 T ES91907138 T ES 91907138T ES 91907138 T ES91907138 T ES 91907138T ES 2072607 T3 ES2072607 T3 ES 2072607T3
Authority
ES
Spain
Prior art keywords
derivatives
thioacetate
indolil
directed
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91907138T
Other languages
English (en)
Inventor
Francesco G Salituro
Bruce M Baron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2072607T3 publication Critical patent/ES2072607T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Hard Magnetic Materials (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVADOS DE 3-INDOLIL TIOACETATO QUE SON ANTAGONISTAS DE NMDA, CON LA FORMULA (I), EN DONDE Z ESTA REPRESENTADO POR H, ALQUILO, FENILO, FENILO SUBSTITUIDO O UN SUBSTITUYENTE DE ALQUILFENILO EN EL QUE EL ANILLO DE FENILO SE PUEDE SUBSTITUIR OPCIONALMENTE; X ESTA REPRESENTADO POR S, SO O SO2; M ESTA REPRESENTADO POR UN ENTERO DEL 1 AL 4; R ESTA REPRESENTADO POR HIDROGENO, HALOGENO, ALQUILO, ALCOXI, CF3, OCF3, OH, NO2 O CN; R1 Y R2, CADA UNO INDEPENDIENTEMENTE, ESTAN REPRESENTADOS POR -OH, -OR3, -NR4R5, OCH2OR3 O -O-(CH2)N-NR6R7, EN DONDE N ES UN ENTERO DEL 1 AL 4; R3 ESTA REPRESENTADO POR ALQUILO, FENILO, FENILO SUBSTITUIDO O UN SUBSTITUYENTE DE ALQUILFENILO EN EL QUE EL ANILLO DE FENILO SE PUEDE SUBSTITUIR OPCIONALMENTE; R4 Y R5, CADA UNO INDEPENDIENTEMENTE, ESTAN REPRESENTADOS POR HIDROGENO O UN ALQUILO; R6 Y R7, CADA UNO INDEPENDIENTEMENTE, ESTAN REPRESENTADOS POR HIDROGENO O ALQUILO O R6 Y R7 JUNTO CON EL ATOMO DE NITROGENO ADYACENTE FORMAN UN GRUPO PIPERIDINO, MORFOLINO O PIRROLIDINO; YSUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES.
ES91907138T 1990-04-25 1991-03-28 Derivados 3 indolil tioacetato. Expired - Lifetime ES2072607T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/514,074 US5051442A (en) 1990-04-25 1990-04-25 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof

Publications (1)

Publication Number Publication Date
ES2072607T3 true ES2072607T3 (es) 1995-07-16

Family

ID=24045696

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91907138T Expired - Lifetime ES2072607T3 (es) 1990-04-25 1991-03-28 Derivados 3 indolil tioacetato.

Country Status (14)

Country Link
US (1) US5051442A (es)
EP (1) EP0526478B1 (es)
JP (1) JP3006881B2 (es)
KR (1) KR0178281B1 (es)
AT (1) ATE119882T1 (es)
AU (1) AU646251B2 (es)
CA (1) CA2081330C (es)
DE (1) DE69108234T2 (es)
DK (1) DK0526478T3 (es)
ES (1) ES2072607T3 (es)
FI (1) FI98454C (es)
HU (1) HU213205B (es)
NO (1) NO178857C (es)
WO (1) WO1991016307A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189054A (en) * 1990-11-02 1993-02-23 Merrell Dow Pharmaceuticals Inc. 3-amidoindolyl derivatives and pharmaceutical compositions thereof
US5318985A (en) * 1991-12-20 1994-06-07 Merrell Dow Pharmaceuticals Inc. Potentiation of NMDA antagonists
USRE39300E1 (en) 1993-01-28 2006-09-19 Virginia Commonwealth University Medical College Of Virginia Inhibiting the development of tolerance to and/or dependence on an addictive substance
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
NZ314601A (en) * 1996-04-19 1999-09-29 American Home Prod 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole derivatives as estrogenic agents and pharmaceutical compositions
US6069153A (en) * 1998-05-12 2000-05-30 American Home Products Corporation Indenoindoles and benzocarbazoles as estrogenic agents
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
US6159959A (en) * 1999-05-06 2000-12-12 American Home Products Corporation Combined estrogen and antiestrogen therapy
WO2011159840A2 (en) 2010-06-16 2011-12-22 Ardea Biosciences, Inc. Phenylthioacetate compounds, compositions and methods of use
AR081930A1 (es) 2010-06-16 2012-10-31 Ardea Biosciences Inc Compuestos de tioacetato
EP2776028B1 (en) 2011-11-03 2018-10-17 Ardea Biosciences, Inc. 3,4-di-substituted pyridine compound, methods of using and compositions comprising the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675332A (en) * 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
IL84796A (en) * 1986-12-17 1992-03-29 Merck Frosst Canada Inc Substituted n-benzyl-indoles and pharmaceutical compositions containing them
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
JPH0347123A (ja) * 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物

Also Published As

Publication number Publication date
FI98454C (fi) 1997-06-25
NO178857C (no) 1996-06-19
DE69108234T2 (de) 1995-08-24
KR937000438A (ko) 1993-03-15
AU646251B2 (en) 1994-02-17
CA2081330A1 (en) 1991-10-26
HU9203336D0 (en) 1993-01-28
ATE119882T1 (de) 1995-04-15
EP0526478B1 (en) 1995-03-15
NO178857B (no) 1996-03-11
US5051442A (en) 1991-09-24
FI924642A (fi) 1992-10-14
DK0526478T3 (da) 1995-05-29
JP3006881B2 (ja) 2000-02-07
FI924642A0 (fi) 1992-10-14
CA2081330C (en) 2002-02-05
KR0178281B1 (ko) 1999-03-20
HU213205B (en) 1997-03-28
HUT64744A (en) 1994-02-28
FI98454B (fi) 1997-03-14
NO924126D0 (no) 1992-10-23
WO1991016307A1 (en) 1991-10-31
DE69108234D1 (en) 1995-04-20
JPH07500567A (ja) 1995-01-19
EP0526478A1 (en) 1993-02-10
AU7650091A (en) 1991-11-11
NO924126L (no) 1992-10-23

Similar Documents

Publication Publication Date Title
NO930035D0 (no) Eksitatoriske aminosyreantagonister
ES2072607T3 (es) Derivados 3 indolil tioacetato.
DE3873907D1 (de) Substituierte alkylamide von teicoplanin-verbindungen.
DE69230224D1 (de) Potenzierung von nmda-antagonisten
ES2089511T3 (es) Dihidroquinolina antagonistas de nmda.
ES2083478T3 (es) Antagonistas de nmda heterociclicos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 526478

Country of ref document: ES