ES2071675T3 - Clonacion y expresion de una proteina que modula la respuesta celular al interferon de tipo i. - Google Patents

Clonacion y expresion de una proteina que modula la respuesta celular al interferon de tipo i.

Info

Publication number
ES2071675T3
ES2071675T3 ES89403131T ES89403131T ES2071675T3 ES 2071675 T3 ES2071675 T3 ES 2071675T3 ES 89403131 T ES89403131 T ES 89403131T ES 89403131 T ES89403131 T ES 89403131T ES 2071675 T3 ES2071675 T3 ES 2071675T3
Authority
ES
Spain
Prior art keywords
protein
modulates
cloning
expression
cell response
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89403131T
Other languages
English (en)
Inventor
Michel Revel
Lester Shulman
Marc Fellous
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of ES2071675T3 publication Critical patent/ES2071675T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

EL GEN CODIFICANDO UNA PROTEINA (L7), LA CUAL APARECE PARA SER UNA PARTE DEL RECEPTOR HUMANO INTERFERON TIPO I HA SIDO CLONADA Y EXPRESADA POR TECNICAS DE RECOMBINACION DE DNA. LA PROTEINA PRODUCE UNA MEJORA ESPECIFICA EN RESPUESTA AL INTERFERON TIPO I PARA CELULAS TRANSFORMADAS. LA PROTEINA SE HA ENCONTRADO SOBRE LA SUPERFICIE DE CELULAS DE DAUDI Y TIENE RASGOS ESTRUCTURALES CARACTERISTICOS DE RECEPTOR DE PROTEINAS.
ES89403131T 1988-11-14 1989-11-14 Clonacion y expresion de una proteina que modula la respuesta celular al interferon de tipo i. Expired - Lifetime ES2071675T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL8837788A IL88377A (en) 1988-11-14 1988-11-14 Cloning and expression of a protein which modulates cellular response to type I interferon

Publications (1)

Publication Number Publication Date
ES2071675T3 true ES2071675T3 (es) 1995-07-01

Family

ID=11059417

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89403131T Expired - Lifetime ES2071675T3 (es) 1988-11-14 1989-11-14 Clonacion y expresion de una proteina que modula la respuesta celular al interferon de tipo i.

Country Status (14)

Country Link
US (1) US5358867A (es)
EP (1) EP0369877B1 (es)
JP (1) JP3156724B2 (es)
AT (1) ATE122393T1 (es)
AU (1) AU628895B2 (es)
CA (1) CA2002862C (es)
DE (1) DE68922582T2 (es)
DK (1) DK169890A (es)
ES (1) ES2071675T3 (es)
FI (1) FI104495B (es)
IL (1) IL88377A (es)
NO (1) NO311181B1 (es)
WO (1) WO1990005737A1 (es)
ZA (1) ZA898680B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06510061A (ja) * 1991-08-30 1994-11-10 ジェネンテク，インコーポレイテッド Ｉｄｄｍの治療法
EP0563487A1 (en) * 1992-03-31 1993-10-06 Laboratoire Europeen De Biotechnologie S.A. Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon
US5821078A (en) 1992-09-03 1998-10-13 Yeda Research And Development Co. Ltd. Nucleic acid encoding interferon-α/β binding protein
IL106591A (en) * 1992-09-03 2008-03-20 Yeda Res & Dev Interferon alpha/beta binding protein, its preparation and pharmaceutical compositions containing it
EP0725654A1 (en) * 1993-09-17 1996-08-14 Laboratoire Europeen De Biotechnologie S.A. Pharmaceutical composition comprising monoclonal antibodies against the interferon receptor, with neutralizing activity against type i interferon
US6740519B1 (en) 1997-11-03 2004-05-25 Mount Sinai School Of Medicine Immortalized, homozygous stat1-deficient mammalian cell lines and their uses
MXPA05011409A (es) 2003-04-23 2005-12-12 Medarex Inc Composiciones y metodos para la terapia de enfermedad inflamatoria intestinal.
PT2662390T (pt) 2004-06-21 2017-10-09 Squibb & Sons Llc Anticorpos contra recetor 1 do interferão alfa e as suas utilizações
EP3672986A1 (en) 2017-08-22 2020-07-01 Sanabio, LLC Soluble interferon receptors and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808523A (en) * 1984-11-07 1989-02-28 Yeda Research And Development Co., Ltd. Constitutive production of human IFN-β1 by mammalian cells transformed by the IFN-β1 gene fused to an SV40 early promoter

Also Published As

Publication number Publication date
NO903118D0 (no) 1990-07-12
FI903577A0 (fi) 1990-07-13
DK169890A (da) 1990-09-14
US5358867A (en) 1994-10-25
CA2002862C (en) 1999-01-26
DK169890D0 (da) 1990-07-13
EP0369877A1 (en) 1990-05-23
AU628895B2 (en) 1992-09-24
JPH03503366A (ja) 1991-08-01
DE68922582T2 (de) 1995-09-07
IL88377A0 (en) 1989-06-30
EP0369877B1 (en) 1995-05-10
ATE122393T1 (de) 1995-05-15
DE68922582D1 (de) 1995-06-14
CA2002862A1 (en) 1990-05-14
JP3156724B2 (ja) 2001-04-16
NO311181B1 (no) 2001-10-22
IL88377A (en) 1996-09-12
ZA898680B (en) 1991-04-24
FI104495B (fi) 2000-02-15
WO1990005737A1 (en) 1990-05-31
NO903118L (no) 1990-08-27
AU4666189A (en) 1990-06-12

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