ES2068812T3 - Cefadroxil cristalino y metodo para producirlo. - Google Patents
Cefadroxil cristalino y metodo para producirlo.Info
- Publication number
- ES2068812T3 ES2068812T3 ES88100478T ES88100478T ES2068812T3 ES 2068812 T3 ES2068812 T3 ES 2068812T3 ES 88100478 T ES88100478 T ES 88100478T ES 88100478 T ES88100478 T ES 88100478T ES 2068812 T3 ES2068812 T3 ES 2068812T3
- Authority
- ES
- Spain
- Prior art keywords
- cefadroxyl
- novel
- producing
- solvate
- cefadroxil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960004841 cefadroxil Drugs 0.000 title abstract 2
- NBFNMSULHIODTC-CYJZLJNKSA-N cefadroxil monohydrate Chemical compound O.C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=C(O)C=C1 NBFNMSULHIODTC-CYJZLJNKSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 2
- ATHHXGZTWNVVOU-UHFFFAOYSA-N N-methylformamide Chemical compound CNC=O ATHHXGZTWNVVOU-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N isopropyl alcohol Natural products CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pyrrole Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN NUEVO HEMIHIDRATO DE CEFADROXILO CRISTALINO QUE TIENE UN K.F ENTRE 3,5 Y 2,0%, QUE ES MAS ESTABLE QUE OTRAS MOLECULAS DE CEFADROXILO. EL NUEVO CEFADROXILO SE OBTIENE PREPARANDO Y AISLANDO UN NUEVO SOLVATO DE DIMETILACETAMIDA DE N-METIL-2-PIRROLIDONA O DE MOMETILFORMAMIDA, PONIENDO EN SUSPENSION DICHO SOLATO CON UNA MEZCLA DE METANOL: ALCOHOL ISOPROPILICO COMPRENDIDO ENTRE 30:70 Y 70:30, EN VOLUMEN, EN PRESENCI DE UNA CANTIDAD DE AGUA ENTRE 5 Y 12%, A UNA TEMPERATURA DE 45 A 55 GRADOS C Y FILTRANDO DESPUES EL COMPUESTO ASI OBTENIDO.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878709804A GB8709804D0 (en) | 1987-04-24 | 1987-04-24 | Crystalline cefadroxil |
| GB878718394A GB8718394D0 (en) | 1987-08-04 | 1987-08-04 | Crystalline cefadroxil hemihydrate |
| US07/089,168 US4904776A (en) | 1987-04-24 | 1987-08-25 | Method for producing crystalline cefadroxil hemihydrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2068812T3 true ES2068812T3 (es) | 1995-05-01 |
Family
ID=27263404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88100478T Expired - Lifetime ES2068812T3 (es) | 1987-04-24 | 1988-01-14 | Cefadroxil cristalino y metodo para producirlo. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4904776A (es) |
| EP (1) | EP0287751B1 (es) |
| JP (1) | JP2620582B2 (es) |
| CN (1) | CN1019804B (es) |
| AT (1) | ATE116322T1 (es) |
| AU (1) | AU595415B2 (es) |
| DE (1) | DE3852560T2 (es) |
| DK (1) | DK13888A (es) |
| ES (1) | ES2068812T3 (es) |
| FI (1) | FI87569C (es) |
| PH (1) | PH26292A (es) |
| PT (1) | PT86653B (es) |
| SU (1) | SU1630613A3 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8714180D0 (en) * | 1987-06-17 | 1987-07-22 | Rifar Srl | Anhydrous crystalline cefadroxil |
| ES2023560A6 (es) * | 1989-07-10 | 1992-01-16 | Gema Sa | Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida. |
| WO2001004126A1 (en) * | 1999-07-14 | 2001-01-18 | Ranbaxy Laboratories Limited | Process for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethylformamide solvate |
| IN190389B (es) | 1999-07-14 | 2003-07-26 | Ranbaxy Lab Ltd | |
| CN1311830C (zh) * | 2004-02-27 | 2007-04-25 | 石药集团中奇制药技术（石家庄）有限公司 | 头孢羟氨苄口腔崩解片及其制备方法 |
| ES2609633T3 (es) * | 2006-05-19 | 2017-04-21 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Proceso para la cristalización de cefadroxilo monohidrato |
| CN102134250B (zh) * | 2011-01-19 | 2013-03-13 | 天津大学 | 一种头孢羟氨苄单水合物的结晶方法及结晶 |
| CN104447795B (zh) * | 2014-11-28 | 2016-08-17 | 珠海金鸿药业股份有限公司 | 一种头孢羟氨苄化合物及其药物组合物 |
| CN105534937B (zh) * | 2015-12-30 | 2019-12-03 | 石药集团欧意药业有限公司 | 一种头孢羟氨苄片剂及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1532682A (en) * | 1976-04-27 | 1978-11-22 | Bristol Myers Co | Process for the preparation of cephadroxil |
| US4504697A (en) * | 1982-04-28 | 1985-03-12 | Littelfuse, Inc. | Sealed electrical devices |
-
1987
- 1987-08-25 US US07/089,168 patent/US4904776A/en not_active Expired - Fee Related
-
1988
- 1988-01-13 DK DK013888A patent/DK13888A/da not_active Application Discontinuation
- 1988-01-14 ES ES88100478T patent/ES2068812T3/es not_active Expired - Lifetime
- 1988-01-14 DE DE3852560T patent/DE3852560T2/de not_active Expired - Fee Related
- 1988-01-14 AT AT88100478T patent/ATE116322T1/de not_active IP Right Cessation
- 1988-01-14 EP EP88100478A patent/EP0287751B1/en not_active Expired - Lifetime
- 1988-01-14 AU AU10285/88A patent/AU595415B2/en not_active Ceased
- 1988-01-28 PT PT86653A patent/PT86653B/pt not_active IP Right Cessation
- 1988-02-02 JP JP63022670A patent/JP2620582B2/ja not_active Expired - Lifetime
- 1988-02-15 SU SU884355195A patent/SU1630613A3/ru active
- 1988-03-07 FI FI881038A patent/FI87569C/fi not_active IP Right Cessation
- 1988-04-04 PH PH36729A patent/PH26292A/en unknown
- 1988-04-06 CN CN88101895A patent/CN1019804B/zh not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SU1630613A3 (ru) | 1991-02-23 |
| JPS63267789A (ja) | 1988-11-04 |
| PH26292A (en) | 1992-04-10 |
| EP0287751A3 (en) | 1990-05-02 |
| CN1019804B (zh) | 1992-12-30 |
| DE3852560D1 (de) | 1995-02-09 |
| ATE116322T1 (de) | 1995-01-15 |
| PT86653A (pt) | 1988-02-01 |
| FI881038A0 (fi) | 1988-03-07 |
| US4904776A (en) | 1990-02-27 |
| DE3852560T2 (de) | 1995-05-04 |
| PT86653B (pt) | 1992-07-31 |
| EP0287751A2 (en) | 1988-10-26 |
| FI87569B (fi) | 1992-10-15 |
| DK13888D0 (da) | 1988-01-13 |
| FI881038A (fi) | 1988-10-25 |
| AU595415B2 (en) | 1990-03-29 |
| JP2620582B2 (ja) | 1997-06-18 |
| AU1028588A (en) | 1988-10-27 |
| CN88101895A (zh) | 1988-11-30 |
| DK13888A (da) | 1988-10-25 |
| FI87569C (fi) | 1993-01-25 |
| EP0287751B1 (en) | 1994-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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