ES2064282A1 - Proceso microbiano para la prteparacion de mevinolina. - Google Patents

Proceso microbiano para la prteparacion de mevinolina.

Info

Publication number
ES2064282A1
ES2064282A1 ES09301350A ES9301350A ES2064282A1 ES 2064282 A1 ES2064282 A1 ES 2064282A1 ES 09301350 A ES09301350 A ES 09301350A ES 9301350 A ES9301350 A ES 9301350A ES 2064282 A1 ES2064282 A1 ES 2064282A1
Authority
ES
Spain
Prior art keywords
formula
strain
delta
hexahydro
dihydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301350A
Other languages
English (en)
Other versions
ES2064282B1 (es
Inventor
Antonia Jekkel
Eva Ilkoy
Istvan Mihaly Szabo
Gabor Ambrus
Attila Andor
Ilona Varga
Imre Moravcsik
Istvan Szabo
Janos Erdei
Kalman Polya
Andras Kiss
Laszlo Cseke
Karoly Nagy
Mihaly Kaszas
Lajos Kiss
Istvan Magyi
Edit Halasz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of ES2064282A1 publication Critical patent/ES2064282A1/es
Application granted granted Critical
Publication of ES2064282B1 publication Critical patent/ES2064282B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

EL INVENTO SE REFIERE A UN PROCESO MICROBIANO PARA LA PREPARACION DE LA DELTA-LACTONA DEL ACIDO BETA, DELTADIHIDROXI-7-[1,2,6,7,8,8A-HEXAHIDRO-2,6-DIMETIL-8- (2METILBUTIRILOXI) -NAFTALEN-1-IL]-EPTANOICO DE FORMULA (I) Y DEL ACIDO BETA, DELTA-DIHIDROXI-7-[1,2,6,7,8A-HEXAHIDRO- 2,6DIMETIL-8- (2-METILBUTIRILOXI) -NAFTALEN-1-IL]-HEPTANCICO DE FORMULA (II), POR LA FERMENTACION AEROBICA DEL CULTIVO SUMERGIDO DE UNA CEPA DE HONGOS IMPERFECTA, BIOSINTETIZANDO LOS COMPUESTOS ARRIBA INDICADOS EN UN MEDIO NUTRIENTE QUE CONTIENE FUENTES DE CARBONO Y NITROGENO APROVECHABLES ASI COMO SALES MINERALES, Y AISLANDO EL PRODUCTO DE FORMULA (I) QUE COMPRENDE EL CULTIVO DE UNA CEPA DE UNA ESPECIE DE HONGOS NUEVA ASPERGILLUS OBSCURUS QUE PRODUCE EL/LOS COMPUESTO(S) ARRIBA INDICADOS DE FORMULAS (I) Y/O (II) DENTRO DE UN RANGO DE TEMPERATURAS DE 25 A 30GC Y, SI SE DESEA, SEPARANDO EL/LOS PRODUCTO(S) FORMADO EN EL CALDO DE FERMENTACION, AISLANDOLO DESPUES EN SU FORMA DE LACTONA DE FORMULA (I) Y, SI SE DESEA, PURIFICANDO EL MISMO.
ES09301350A 1992-06-17 1993-06-17 Proceso microbiano para la prteparacion de mevinolina. Expired - Fee Related ES2064282B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9202020A HU208997B (en) 1992-06-17 1992-06-17 Microbiological method for producing mevinoline

Publications (2)

Publication Number Publication Date
ES2064282A1 true ES2064282A1 (es) 1995-01-16
ES2064282B1 ES2064282B1 (es) 1995-08-01

Family

ID=10982069

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09301350A Expired - Fee Related ES2064282B1 (es) 1992-06-17 1993-06-17 Proceso microbiano para la prteparacion de mevinolina.

Country Status (9)

Country Link
US (1) US5403728A (es)
AT (1) AT399722B (es)
CA (1) CA2098698C (es)
DE (1) DE4320023A1 (es)
ES (1) ES2064282B1 (es)
GR (1) GR1002573B (es)
HU (1) HU208997B (es)
IT (1) IT1264629B1 (es)
JO (1) JO1764B1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US20060223150A1 (en) * 1993-09-08 2006-10-05 Vilmos Keri Process for the isolation and purification of mevinolin
SI9500238A (en) * 1995-07-27 1997-02-28 Krka Tovarna Zdravil Procedure for the production of lovastatin
EP0877089A1 (en) * 1997-05-07 1998-11-11 Gist-Brocades B.V. HMG-CoA reductase inhibitor preparation process
KR100234976B1 (ko) * 1997-08-01 1999-12-15 김충환 세룰레닌 및 엘-메치오닌 유사체에 동시 내성을 갖는 아스퍼질 러스속 미생물 및 그를 이용한 메비놀린산의 제조방법
IL132822A0 (en) * 1998-03-20 2001-03-19 Biogal Gyogyszergyar Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid
HU226966B1 (en) * 1998-03-20 2010-03-29 Teva Gyogyszergyar Zartkoeruee Fermentation process
KR100342789B1 (ko) * 1999-10-29 2002-07-04 김용규 니스타틴에 내성을 갖는 아스퍼질러스속 미생물 및 그를 이용한 트리올 헵타노익산의 제조방법
IL151290A0 (en) 2000-02-24 2003-04-10 Biogal Pharmaceutical Co Ltd Method of purifying a fermentation broth
IN192861B (es) * 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
EP1176208A1 (en) * 2000-07-28 2002-01-30 Société des Produits Nestlé S.A. Koji molds and use thereof for preparing cholesterol-lowering products
KR100379075B1 (en) * 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
US20070020554A1 (en) * 2005-07-25 2007-01-25 Xerox Corporation Toner process
TWI415619B (zh) * 2011-08-02 2013-11-21 Sunway Biotech Co Ltd 一種可降血脂且提升高密度脂蛋白膽固醇之組合物及其製造方法
CN112481139B (zh) * 2020-12-22 2022-08-05 华东理工大学 利用海洋真菌黄柄曲霉hn4-13生产大黄素的培养基及其制备方法
CN115232096B (zh) * 2022-06-15 2023-05-05 福建卫生职业技术学院 源于细曲霉的内酯类化合物及其制备方法和在抗人肝癌药物中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
EP0337548A2 (en) * 1988-04-15 1989-10-18 Merck & Co. Inc. HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
EP0381478A1 (en) * 1989-02-01 1990-08-08 Merck & Co. Inc. Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
DE3682557D1 (de) * 1985-09-13 1992-01-02 Sankyo Co Hydroxy-ml-236b-derivate, deren herstellung und anwendung.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
EP0337548A2 (en) * 1988-04-15 1989-10-18 Merck & Co. Inc. HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
EP0381478A1 (en) * 1989-02-01 1990-08-08 Merck & Co. Inc. Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)

Also Published As

Publication number Publication date
DE4320023A1 (de) 1993-12-23
AT399722B (de) 1995-07-25
HU208997B (en) 1994-02-28
GR930100259A (el) 1994-02-28
CA2098698A1 (en) 1993-12-18
ATA118993A (de) 1994-11-15
HU9202020D0 (en) 1992-10-28
ES2064282B1 (es) 1995-08-01
JO1764B1 (en) 1994-05-15
CA2098698C (en) 1998-05-19
ITMI931306A0 (it) 1993-06-17
ITMI931306A1 (it) 1994-12-17
IT1264629B1 (it) 1996-10-04
US5403728A (en) 1995-04-04
GR1002573B (el) 1997-02-06

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FD1A Patent lapsed

Effective date: 20050618