ES2058070T3 - Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos. - Google Patents
Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos.Info
- Publication number
- ES2058070T3 ES2058070T3 ES87105548T ES87105548T ES2058070T3 ES 2058070 T3 ES2058070 T3 ES 2058070T3 ES 87105548 T ES87105548 T ES 87105548T ES 87105548 T ES87105548 T ES 87105548T ES 2058070 T3 ES2058070 T3 ES 2058070T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- malignant tumors
- medicinal product
- prevent metastasis
- specific monosaccharides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Solid Fuels And Fuel-Associated Substances (AREA)
Abstract
MEDIOS Y PROCEDIMIENTO PARA EVITAR LAS METASTASIS DE LOS TUMORES MALIGNOS, CON LA UTILIZACION DE MONOSACARIDOS ESPECIFICOS PARA ORGANOCELULOLECTINA, Y/O PREFERENTEMENTE LOS GLICOCONJUGADOS RESULTANTES, CONTENIENDO ESTOS MONOSACARIDOS, ESPECIALMENTE LA (BETA) OS, QUE CONTIENEN (BETA) - D - GALACTOSA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3615621 | 1986-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058070T3 true ES2058070T3 (es) | 1994-11-01 |
Family
ID=6300445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87105548T Expired - Lifetime ES2058070T3 (es) | 1986-05-09 | 1987-04-14 | Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4946830A (es) |
EP (1) | EP0249008B1 (es) |
JP (1) | JPH07100658B2 (es) |
AT (1) | ATE94395T1 (es) |
DE (1) | DE3787403D1 (es) |
ES (1) | ES2058070T3 (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5490991A (en) * | 1986-07-03 | 1996-02-13 | Advanced Magnetics, Inc. | Directed delivery of radioprotectants using a receptor specific carrier |
US5554386A (en) * | 1986-07-03 | 1996-09-10 | Advanced Magnetics, Inc. | Delivery of therapeutic agents to receptors using polysaccharides |
US5679323A (en) * | 1986-07-03 | 1997-10-21 | Advanced Magnetics, Inc. | Hepatocyte-specific receptor-mediated endocytosis-type compositions |
EP0546122A1 (en) * | 1990-08-30 | 1993-06-16 | The Biomembrane Institute | Inhibition of metastasis potential and invasiveness by oligosaccharides or oligosaccharide antigens or antibodies |
KR100192862B1 (ko) * | 1991-01-10 | 1999-06-15 | 슈테펜엘.네스비트 | 항당뇨병제로서 유용한 신규한 글루코하이드롤라제 억제제 |
US6121233A (en) * | 1991-04-19 | 2000-09-19 | John L. Magnani | Methods for the inhibition of cancer metastasis mediated by endothelial adhesion molecules |
EP0521692A3 (en) * | 1991-07-02 | 1993-02-03 | The Biomembrane Institute | Inhibition of tumor cell metastasis potential and invasiveness by chemically-defined oligosaccharides, their derivatives, mimetics and antibodies directed to them |
US5639737A (en) * | 1991-11-04 | 1997-06-17 | Co Enzyme Technology Ltd. | Method and compositions for treating malignant tumors and inhibiting growth and metastases of malignant tumors |
US5760008A (en) * | 1991-11-04 | 1998-06-02 | Co Enzyme Technology Ltd. | Method and compositions for treating malignant tumors and inhibiting metastases of malignant tumors |
US5376531A (en) * | 1992-09-03 | 1994-12-27 | Northwestern University | Method of detecting cancer |
ATE196296T1 (de) * | 1992-12-16 | 2000-09-15 | Basf Ag | Dolastatin analog |
GB9315846D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tumour inhibitors |
US5654273A (en) * | 1994-09-22 | 1997-08-05 | Children's Medical Center Corporation | Synducin mediated modulation of tissue repair |
AU2003249641B2 (en) | 2002-05-16 | 2009-08-20 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
AU2003245595A1 (en) * | 2002-07-03 | 2004-01-23 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
EP1643969A2 (en) * | 2003-07-11 | 2006-04-12 | Pro-Pharmaceuticals, Inc. | Compositions and methods for hydrophobic drug delivery |
US20050053664A1 (en) * | 2003-09-08 | 2005-03-10 | Eliezer Zomer | Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer |
AU2003271016A1 (en) * | 2003-09-17 | 2005-04-06 | Bio-Wave Institute Of Suzhou Hi-Tech New District Corporation, Ltd. | Use of n-acetyl-d-aminoglycosamine in preparation of drugs for the treatment of cacer and metastasis |
ATE383367T1 (de) * | 2003-11-19 | 2008-01-15 | Glycomimetics Inc | Spezifischer antagonist sowohl für e- als auch p- selektine |
JP2007524658A (ja) * | 2003-11-19 | 2007-08-30 | グリコミメティクス, インコーポレイテッド | E−およびp−セレクチンの両方のための糖模倣物アンタゴニスト |
WO2005079314A2 (en) * | 2004-02-13 | 2005-09-01 | Pro-Pharmaceuticals, Inc. | Compositions and methods used to treat acne and candida |
WO2005092097A1 (en) * | 2004-03-19 | 2005-10-06 | Pro-Pharmaceuticals, Inc. | Compositions and methods for targeting metastatic tumors using multivalent ligand-linked carbohydrate polymers |
US20080286251A1 (en) * | 2004-08-02 | 2008-11-20 | Propharmaceuticals, Inc. | Compositions and Methods for the Enhancement of Chemotherapy with Microbial Cytotoxins |
US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
US20090036386A1 (en) * | 2005-05-25 | 2009-02-05 | Glycomimetics, Inc | Heterobifunctional compounds for selectin inhibition |
US7517980B2 (en) * | 2005-08-09 | 2009-04-14 | Glycomimetics, Inc. | Glycomimetric inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas |
SI2264043T1 (en) * | 2005-09-02 | 2018-01-31 | Glycomimetics, Inc. | HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS |
WO2007143052A1 (en) * | 2006-06-01 | 2007-12-13 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
WO2008060378A2 (en) * | 2006-10-12 | 2008-05-22 | Glycomimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
EP2457573A1 (en) * | 2007-02-09 | 2012-05-30 | GlycoMimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and N-Acetyl hexosamines |
US8039442B2 (en) | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
US8895510B2 (en) * | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
AU2009257536B2 (en) * | 2008-06-13 | 2015-07-02 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
CN102421441B (zh) * | 2009-05-01 | 2015-04-01 | 糖模拟物有限公司 | E-选择蛋白和cxcr4趋化因子受体的异双功能抑制剂 |
WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
JP2015500887A (ja) | 2011-12-22 | 2015-01-08 | グリコミメティクス, インコーポレイテッド | E−セレクチンアンタゴニスト化合物、組成物および使用方法 |
HUE038423T2 (hu) | 2012-12-07 | 2018-10-29 | Glycomimetics Inc | E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára |
PT3227310T (pt) | 2014-12-03 | 2019-11-06 | Glycomimetics Inc | Inibidores heterobifuncionais de e-selectinas e recetores de quimiocina cxcr4 |
CA3009836A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
KR102653723B1 (ko) | 2016-10-07 | 2024-04-01 | 글리코미메틱스, 인크. | 매우 강력한 다량체성 e-셀렉틴 길항물질 |
US11197877B2 (en) | 2017-03-15 | 2021-12-14 | Glycomimetics. Inc. | Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists |
US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
CA3085356A1 (en) | 2017-12-29 | 2019-07-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
BR112020018184A2 (pt) | 2018-03-05 | 2021-02-02 | Glycomimetics, Inc. | usos de compostos |
US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1158456A (en) * | 1967-06-13 | 1969-07-16 | Prodotti Antibiotici Spa | Preparations Containing Sugars |
US3931402A (en) * | 1970-12-02 | 1976-01-06 | Societa Prodotti Antibiotici S.P.A. | Preparations containing hexoses |
US4243663A (en) * | 1976-06-25 | 1981-01-06 | Ichiro Azuma | Glycolipid compositions for transplanted tumor immunotherapy |
ES8102679A1 (es) * | 1979-01-30 | 1981-02-16 | Otsuka Pharma Co Ltd | Metodo de analizar fluidos corporales. |
US4334017A (en) * | 1979-04-16 | 1982-06-08 | Massachusetts Institute Of Technology | Method for detecting cancer in mammalian tissue |
FI67386C (fi) * | 1979-06-21 | 1985-03-11 | Hoffmann La Roche | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat |
CA1120399A (en) * | 1979-09-28 | 1982-03-23 | Universite De Sherbrooke | Pharmaceutical compositions for treatment of tumor cells |
GB2106935B (en) * | 1981-10-01 | 1985-01-30 | Otsuka Pharma Co Ltd | Cancer cell-combatting lymphocytes process for the production thereof and anticancer agents containing said lymphocytes |
DE3202894A1 (de) * | 1982-01-29 | 1983-08-11 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Verfahren zur bestimmung von tumor-assoziierten glykoprotein enthaltenden verbindungen, anwendung des verfahrens zur krebsdiagnose und kit fuer die anwendung des verfahrens |
US4496539A (en) * | 1982-02-01 | 1985-01-29 | Massachusetts Institute Of Technology | Method for treating cancer using galactose-specific lectins |
IT1168205B (it) * | 1983-07-21 | 1987-05-20 | Wellcome Italia | Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione |
JPS60190791A (ja) * | 1984-03-09 | 1985-09-28 | Kanto Ishi Pharma Co Ltd | シアル酸誘導体およびその製造法 |
JPS60214737A (ja) * | 1984-04-06 | 1985-10-28 | Nippon Koutai Kenkyusho:Kk | 糖鎖関連抗原の製造法 |
US4742046A (en) * | 1984-08-03 | 1988-05-03 | Medisearch S.A. | Methods and compositions for inhibiting the infectious activity of viruses |
JPS6183125A (ja) * | 1984-09-28 | 1986-04-26 | Kanto Ishi Pharma Co Ltd | 癌転移阻害剤 |
US4656159A (en) * | 1984-10-31 | 1987-04-07 | Georgetown University | Galactose-C-6 nitrogen mustard compounds and their uses |
-
1987
- 1987-04-14 ES ES87105548T patent/ES2058070T3/es not_active Expired - Lifetime
- 1987-04-14 EP EP87105548A patent/EP0249008B1/de not_active Expired - Lifetime
- 1987-04-14 AT AT87105548T patent/ATE94395T1/de not_active IP Right Cessation
- 1987-04-14 DE DE87105548T patent/DE3787403D1/de not_active Expired - Fee Related
- 1987-05-01 US US07/044,483 patent/US4946830A/en not_active Expired - Lifetime
- 1987-05-09 JP JP62113405A patent/JPH07100658B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPS62267234A (ja) | 1987-11-19 |
EP0249008A3 (en) | 1989-09-27 |
ATE94395T1 (de) | 1993-10-15 |
JPH07100658B2 (ja) | 1995-11-01 |
US4946830A (en) | 1990-08-07 |
DE3787403D1 (de) | 1993-10-21 |
EP0249008B1 (de) | 1993-09-15 |
EP0249008A2 (de) | 1987-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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