ES2058030A1 - Procedure for preparing 1-[(2S)-methyl-3- mercaptopropionyl]pyrrolidine-(2S)-carboxylic acid - Google Patents

Procedure for preparing 1-[(2S)-methyl-3- mercaptopropionyl]pyrrolidine-(2S)-carboxylic acid

Info

Publication number
ES2058030A1
ES2058030A1 ES09300495A ES9300495A ES2058030A1 ES 2058030 A1 ES2058030 A1 ES 2058030A1 ES 09300495 A ES09300495 A ES 09300495A ES 9300495 A ES9300495 A ES 9300495A ES 2058030 A1 ES2058030 A1 ES 2058030A1
Authority
ES
Spain
Prior art keywords
pyrrolidine
methyl
carboxylic acid
mercaptopropionyl
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09300495A
Other languages
Spanish (es)
Other versions
ES2058030B1 (en
Inventor
Geza Schneider
Gabor Blasko
Nee Palotai Agnes Kovacs
Nee Lassu Gabriella Urmos
Nee Nagy Ilma Dinnyes
Ivan Beck
Elemer Jakfalvi
Andras Dietz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES2058030A1 publication Critical patent/ES2058030A1/en
Application granted granted Critical
Publication of ES2058030B1 publication Critical patent/ES2058030B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

The invention relates to a new procedure for preparing 1-[(2S)-methyl-3-mercaptopropionyl]pyrrolidine-(2S)- carboxylic acid of formula I, in which the 1-[(2S)-methyl- 3-thiocyanatopropionyl]pyrrolidine-(2S)-carboxylic acid of formula II is dissolved in an aqueous mineral acid, the solution obtained is diluted with water and the 1- [(2S)-methyl-3-carbamoylthiopropionyl]-pyrrolidine-(2S)- carboxylic acid of formula III which is formed is hydrolysed with an aqueous solution of a base. The compound obtained according to the invention is applicable for the treatment of hypertension.
ES9300495A 1992-03-13 1993-03-11 PROCEDURE FOR PREPARING ACID 1- ((2S) -METIL-3-MERCAPTOPROPIONIL-PIRROLIDINA- (2S) -CARBOXILICO. Expired - Fee Related ES2058030B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9200838A HUT64965A (en) 1992-03-13 1992-03-13 Process for the production of 2-imino-selenazolydes and medical preparations containing them

Publications (2)

Publication Number Publication Date
ES2058030A1 true ES2058030A1 (en) 1994-10-16
ES2058030B1 ES2058030B1 (en) 1995-10-01

Family

ID=10981539

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9300495A Expired - Fee Related ES2058030B1 (en) 1992-03-13 1993-03-11 PROCEDURE FOR PREPARING ACID 1- ((2S) -METIL-3-MERCAPTOPROPIONIL-PIRROLIDINA- (2S) -CARBOXILICO.

Country Status (2)

Country Link
ES (1) ES2058030B1 (en)
HU (1) HUT64965A (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8101548A1 (en) * 1979-11-21 1980-12-16 Farmaceutico Quimico Lab Procedure for obtaining a proline derivative (Machine-translation by Google Translate, not legally binding)
ES8105280A1 (en) * 1980-04-24 1981-05-16 Inke Sa Procedure for the obtaining of N- (d-3-mercapto-2-metilpropionil) l-prolin. (Machine-translation by Google Translate, not legally binding)
ES8200340A1 (en) * 1979-12-29 1981-11-16 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of 1-[3-mercapto-(2S)-methylpropionyl]-pyrrolidine-(2S)-carboxylic acid
ES8604514A1 (en) * 1985-04-10 1986-02-01 Farmhispania Mercapto methyl-propanoyl proline
ES8706626A1 (en) * 1986-06-21 1987-07-01 Salvat Mercapto-iso-butyramide deriv. prepn.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8101548A1 (en) * 1979-11-21 1980-12-16 Farmaceutico Quimico Lab Procedure for obtaining a proline derivative (Machine-translation by Google Translate, not legally binding)
ES8200340A1 (en) * 1979-12-29 1981-11-16 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of 1-[3-mercapto-(2S)-methylpropionyl]-pyrrolidine-(2S)-carboxylic acid
ES8105280A1 (en) * 1980-04-24 1981-05-16 Inke Sa Procedure for the obtaining of N- (d-3-mercapto-2-metilpropionil) l-prolin. (Machine-translation by Google Translate, not legally binding)
ES8604514A1 (en) * 1985-04-10 1986-02-01 Farmhispania Mercapto methyl-propanoyl proline
ES8706626A1 (en) * 1986-06-21 1987-07-01 Salvat Mercapto-iso-butyramide deriv. prepn.

Also Published As

Publication number Publication date
HUT64965A (en) 1994-03-28
ES2058030B1 (en) 1995-10-01
HU9200838D0 (en) 1992-05-28

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