ES2056068T3 - Metodo y formulacion para administrar por via oral agentes bioactivos a, y a traves de, la placa de peyer. - Google Patents

Metodo y formulacion para administrar por via oral agentes bioactivos a, y a traves de, la placa de peyer.

Info

Publication number
ES2056068T3
ES2056068T3 ES87309286T ES87309286T ES2056068T3 ES 2056068 T3 ES2056068 T3 ES 2056068T3 ES 87309286 T ES87309286 T ES 87309286T ES 87309286 T ES87309286 T ES 87309286T ES 2056068 T3 ES2056068 T3 ES 2056068T3
Authority
ES
Spain
Prior art keywords
formulation
oral
bioactive agents
peyer
administer bioactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87309286T
Other languages
English (en)
Inventor
Thomas R Tice
Jay K Staas
Richard M Gilley
John H Eldridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UAB Research Foundation
Southern Research Institute
Original Assignee
UAB Research Foundation
Southern Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36954601&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2056068(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by UAB Research Foundation, Southern Research Institute filed Critical UAB Research Foundation
Application granted granted Critical
Publication of ES2056068T3 publication Critical patent/ES2056068T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN METODO Y UNA FORMULACION PARA ADMINISTRACION ORAL DE UN AGENTE BIOACTIVO, QUE CONSISTE EN ENCAPSULAR EL AGENTE EN UNO O MAS EXCIPIENTES DE POLIMERO O COPOLIMERO BIODEGRADABLES Y BIOCOMPATIBLES, PARA FORMAR UNA MICROCAPSULA, QUE ES CAPAZ DE PASAR A TRAVES DEL TRACTO GASTROINTESTINAL SIN SER AFECTADA Y SER TOMADA POR LA CONEXION DE PEYER.
ES87309286T 1986-10-24 1987-10-21 Metodo y formulacion para administrar por via oral agentes bioactivos a, y a traves de, la placa de peyer. Expired - Lifetime ES2056068T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92315986A 1986-10-24 1986-10-24
CN95100893A CN1111157A (zh) 1986-10-24 1995-03-08 用于到达派亚氏***的口服生物活性剂的制法和配方

Publications (1)

Publication Number Publication Date
ES2056068T3 true ES2056068T3 (es) 1994-10-01

Family

ID=36954601

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87309286T Expired - Lifetime ES2056068T3 (es) 1986-10-24 1987-10-21 Metodo y formulacion para administrar por via oral agentes bioactivos a, y a traves de, la placa de peyer.

Country Status (15)

Country Link
EP (1) EP0266119B2 (es)
JP (1) JP2741728B2 (es)
KR (1) KR900003559B1 (es)
CN (1) CN1111157A (es)
AT (1) ATE108650T1 (es)
AU (1) AU607439B2 (es)
CA (1) CA1331738C (es)
DE (1) DE3750247T2 (es)
DK (1) DK175859B1 (es)
ES (1) ES2056068T3 (es)
HK (1) HK122495A (es)
IE (1) IE64786B1 (es)
IL (1) IL84167A (es)
NZ (1) NZ222278A (es)
ZA (1) ZA877946B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ217821A (en) * 1985-10-10 1989-07-27 Biotech Australia Pty Ltd Oral delivery system; complex of active agent and vitamin b12 or analogue thereof
US5811128A (en) * 1986-10-24 1998-09-22 Southern Research Institute Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US5807832A (en) * 1987-06-09 1998-09-15 Biotech Australia Pty Limited Oral delivery of biologically active substances bound to vitamin B12
JP2664906B2 (ja) * 1987-08-13 1997-10-22 ストール・リサーチ・アンド・デイベロップメント・コーポレーション 改良された哺乳類の免疫法
US5444113A (en) * 1988-08-08 1995-08-22 Ecopol, Llc End use applications of biodegradable polymers
EP0550436A1 (en) * 1989-11-06 1993-07-14 Alkermes Controlled Therapeutics, Inc. Protein microspheres and methods of using them
JP3249147B2 (ja) * 1990-06-01 2002-01-21 キリン−アムジエン・インコーポレーテツド 生理活性蛋白含有経口製剤
WO1992017167A1 (en) * 1991-04-02 1992-10-15 Biotech Australia Pty. Ltd. Oral delivery systems for microparticles
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
WO1994007469A1 (en) * 1992-09-25 1994-04-14 Dynagen, Inc. An immunobooster for delayed release of immunogen
JP3841309B2 (ja) * 1993-10-22 2006-11-01 ジェネンテック・インコーポレーテッド 流動床乾燥工程を含んでなるミクロスフェアの製造方法
US6913767B1 (en) 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US6080429A (en) * 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
ATE288270T1 (de) * 1993-11-19 2005-02-15 Janssen Pharmaceutica Nv Mikroverkapselte 1,2-benzazole
US5902565A (en) * 1993-12-24 1999-05-11 Csl Limited Spray dried vaccine preparation comprising aluminium adsorbed immunogens
US6531156B1 (en) 1994-04-15 2003-03-11 Temple University Aqueous solven encapsulation method, apparatus and microcapsules
KR100201352B1 (ko) * 1995-03-16 1999-06-15 성재갑 단일주사 백신 제형
US6265389B1 (en) 1995-08-31 2001-07-24 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of oligonucleotides
CA2230494A1 (en) * 1995-08-31 1997-03-06 Alkermes Controlled Therapeutics Inc. Composition for sustained release of an agent
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
ATE192334T1 (de) * 1995-11-09 2000-05-15 Microbiological Res Authority Mikroverkapselte dna zur impfung und gentherapie
DE19545257A1 (de) * 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US5783567A (en) * 1997-01-22 1998-07-21 Pangaea Pharmaceuticals, Inc. Microparticles for delivery of nucleic acid
US6197229B1 (en) * 1997-12-12 2001-03-06 Massachusetts Institute Of Technology Method for high supercoiled DNA content microspheres
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
JP2002518349A (ja) 1998-06-18 2002-06-25 ジョンズ ホプキンス ユニバーシティ スクール オブ メディシン 核酸デリバリー用ポリマー
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
WO2000012124A1 (en) 1998-09-01 2000-03-09 Elan Corporation, Plc Oral vaccine compositions
CA2361377C (en) 1999-02-05 2009-02-03 Alk-Abello A/S Novel mucosal delivery system
US20020051794A1 (en) 2000-08-09 2002-05-02 Alk-Abello A/S Novel parenteral vaccine formulations and uses thereof
CA2451741C (en) * 2001-07-02 2014-02-18 Elan Corporation, Plc Peyers's patch and/or m-celle targeting ligands
GB0300881D0 (en) * 2003-01-15 2003-02-12 Secr Defence Therapeutic treatment
JP6334214B2 (ja) * 2013-03-08 2018-05-30 学校法人慶應義塾 レーザーを用いた薬剤放出方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3823228A (en) * 1971-09-29 1974-07-09 Univ Illinois Tge virus vaccine
IL54167A (en) * 1977-03-14 1980-05-30 Baxter Travenol Lab Frangible protective sealing arrangement
AU526320B2 (en) * 1979-04-27 1983-01-06 Acme Fluid Foundry Pty. Ltd. Manway cover fastening assembly
AU567155B2 (en) * 1983-04-15 1987-11-12 Damon Biotech Inc. Capsules for releasing core material at constant rate
DE3465888D1 (en) * 1983-06-22 1987-10-15 Univ Ohio State Res Found Small particle formation and encapsulation
GB2144950A (en) * 1983-08-10 1985-03-13 Philips Electronic Associated Data transmission system

Also Published As

Publication number Publication date
IL84167A (en) 1991-04-15
EP0266119A3 (en) 1989-07-26
IE64786B1 (en) 1995-09-06
JP2741728B2 (ja) 1998-04-22
JPS63190833A (ja) 1988-08-08
KR900003559B1 (ko) 1990-05-21
ZA877946B (en) 1988-04-26
DK557787D0 (da) 1987-10-23
AU7992987A (en) 1988-04-28
AU607439B2 (en) 1991-03-07
EP0266119B1 (en) 1994-07-20
IE872851L (en) 1988-04-24
CA1331738C (en) 1994-08-30
CN1111157A (zh) 1995-11-08
EP0266119B2 (en) 2005-05-04
ATE108650T1 (de) 1994-08-15
EP0266119A2 (en) 1988-05-04
NZ222278A (en) 1989-09-27
DE3750247D1 (de) 1994-08-25
KR880004800A (ko) 1988-06-27
HK122495A (en) 1995-08-04
DK175859B1 (da) 2005-04-11
IL84167A0 (en) 1988-03-31
DE3750247T2 (de) 1994-10-27
DK557787A (da) 1988-04-25

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