ES2055686T3 - Procedimiento para preparar proteinas con factor de granulocitos-macrofagos "estimulador de colonias". - Google Patents
Procedimiento para preparar proteinas con factor de granulocitos-macrofagos "estimulador de colonias".Info
- Publication number
- ES2055686T3 ES2055686T3 ES86117484T ES86117484T ES2055686T3 ES 2055686 T3 ES2055686 T3 ES 2055686T3 ES 86117484 T ES86117484 T ES 86117484T ES 86117484 T ES86117484 T ES 86117484T ES 2055686 T3 ES2055686 T3 ES 2055686T3
- Authority
- ES
- Spain
- Prior art keywords
- factor
- macrophagus
- granulocyt
- procedure
- colony stimulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
POR EXPRESION EN BACTERIAS DE UN GEN QUE CODIFICA EL FACTOR ESTIMULANTE DE COLONIAS (CSF) MACROFAGO DE GRANULOCITOS (GM) SE OBTIENEN PROTEINAS CON ACTIVIDAD BIOLOGICA. POR VARIACION DE UNA ESTRUCTURA NATURAL O SINTETICA DEL GEN SE OBTIENEN DERIVADOS BIOLOGICAMENTE ACTIVOS CON UNA SECUENCIA MODIFICADA DE AMINOACIDOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853545568 DE3545568A1 (de) | 1985-12-21 | 1985-12-21 | Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2055686T3 true ES2055686T3 (es) | 1994-09-01 |
Family
ID=6289242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES86117484T Expired - Lifetime ES2055686T3 (es) | 1985-12-21 | 1986-12-16 | Procedimiento para preparar proteinas con factor de granulocitos-macrofagos "estimulador de colonias". |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0228018B1 (es) |
JP (1) | JP2575367B2 (es) |
KR (1) | KR940005585B1 (es) |
AT (1) | ATE71144T1 (es) |
AU (2) | AU601959B2 (es) |
CA (1) | CA1341197C (es) |
DE (2) | DE3545568A1 (es) |
DK (1) | DK170346B1 (es) |
ES (1) | ES2055686T3 (es) |
FI (1) | FI91168C (es) |
GR (1) | GR3003999T3 (es) |
HU (1) | HU202584B (es) |
IE (1) | IE59779B1 (es) |
IL (1) | IL81020A (es) |
NO (1) | NO177270C (es) |
PT (1) | PT83972B (es) |
ZA (1) | ZA869557B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
WO1987002060A1 (en) * | 1985-10-03 | 1987-04-09 | Biogen N.V. | Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells |
US5359035A (en) * | 1985-12-21 | 1994-10-25 | Hoechst Aktiengesellschaft | Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF) |
DE3712985A1 (de) * | 1987-04-16 | 1988-11-03 | Hoechst Ag | Bifunktionelle proteine |
JP2583770B2 (ja) * | 1986-09-17 | 1997-02-19 | 大塚製薬株式会社 | 遺伝子 |
JPS6420097A (en) * | 1987-03-02 | 1989-01-24 | Sumitomo Chemical Co | Human granulocyte-macrophage colony stimulating factor |
PT87133B (pt) * | 1987-04-02 | 1992-07-31 | Amrad Corp Ltd | Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif |
AU609128B2 (en) * | 1987-04-02 | 1991-04-26 | Amrad Operations Pty. Limited | Leukaemia-inhibitory factor |
AU602097B2 (en) * | 1987-06-25 | 1990-09-27 | Immunex Corporation | Bovine granulocyte-macrophage colony stimulating factor |
JPH0649655B2 (ja) * | 1987-11-12 | 1994-06-29 | シェリング・コーポレーション | Gm‐csfによる骨形成の促進 |
GB2212159B (en) * | 1987-11-13 | 1992-01-22 | British Bio Technology | Synthetic gene for human granulocyte/macrophage colony stimulating factor. |
JPH03503897A (ja) * | 1988-04-21 | 1991-08-29 | メドベット・サイエンス・プロプライアテリー・リミテッド | ひとgm‐csf変異形類 |
AU5355790A (en) * | 1989-04-19 | 1990-11-16 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
DK0489116T3 (da) * | 1989-08-22 | 1994-05-02 | Immunex Corp | Fusionsproteiner omfattende GM-CSF og IL-3 |
NZ236819A (en) * | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
US5270181A (en) * | 1991-02-06 | 1993-12-14 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
US6060258A (en) * | 1995-09-28 | 2000-05-09 | Otsuka Pharmaceutical Co., Ltd. | Neutrophil chemotactic lymphokine, and method for the diagnosis of drug hypersensitive granulocytopenia using the same |
KR100448021B1 (ko) * | 2001-12-28 | 2004-09-08 | 크레아젠 주식회사 | 마우스 과립구 대식세포 콜로니 촉진인자 발현벡터 pGM-CSF로 형질전환된 대장균 및 상기 마우스 과립구 대식세포 콜로니 촉진인자의 대량생산방법 |
KR101548567B1 (ko) | 2009-12-23 | 2015-09-01 | 그래댈리스, 인코포레이티드 | 푸린―녹다운 및 gm―csf―증강된 (fang) 암 백신 |
SG181881A1 (en) | 2009-12-23 | 2012-07-30 | Gradalis Inc | Furin-knockdown bi-functional rna |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4438032A (en) * | 1981-01-30 | 1984-03-20 | The Regents Of The University Of California | Unique T-lymphocyte line and products derived therefrom |
SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
AU594014B2 (en) * | 1984-03-21 | 1990-03-01 | Research Corporation Technologies, Inc. | Recombinant DNA molecules |
AU599572B2 (en) * | 1984-07-06 | 1990-07-26 | Novartis Ag | Lymphokine production and purification |
ZA856108B (en) * | 1984-10-29 | 1986-10-29 | Immunex Corp | Cloning of human granulocyte-macrophage colony simulating factor gene |
AU588819B2 (en) * | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
ZA858833B (en) * | 1984-11-20 | 1986-06-25 | Schering Biotech Corp | Cdna clones coding for polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity |
WO1987002060A1 (en) * | 1985-10-03 | 1987-04-09 | Biogen N.V. | Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells |
DE3636903A1 (de) * | 1985-12-21 | 1987-07-02 | Hoechst Ag | Fusionsproteine mit eukaryotischem ballastanteil |
DE3541856A1 (de) * | 1985-11-27 | 1987-06-04 | Hoechst Ag | Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens |
-
1985
- 1985-12-21 DE DE19853545568 patent/DE3545568A1/de not_active Withdrawn
-
1986
- 1986-12-16 ES ES86117484T patent/ES2055686T3/es not_active Expired - Lifetime
- 1986-12-16 DE DE8686117484T patent/DE3683267D1/de not_active Expired - Lifetime
- 1986-12-16 EP EP86117484A patent/EP0228018B1/de not_active Expired - Lifetime
- 1986-12-16 AT AT86117484T patent/ATE71144T1/de not_active IP Right Cessation
- 1986-12-18 FI FI865186A patent/FI91168C/fi not_active IP Right Cessation
- 1986-12-18 IL IL8102086A patent/IL81020A/en active IP Right Grant
- 1986-12-19 NO NO865191A patent/NO177270C/no unknown
- 1986-12-19 CA CA000525856A patent/CA1341197C/en not_active Expired - Fee Related
- 1986-12-19 PT PT83972A patent/PT83972B/pt not_active IP Right Cessation
- 1986-12-19 HU HU865355A patent/HU202584B/hu not_active IP Right Cessation
- 1986-12-19 IE IE333586A patent/IE59779B1/en not_active IP Right Cessation
- 1986-12-19 AU AU66756/86A patent/AU601959B2/en not_active Ceased
- 1986-12-19 ZA ZA869557A patent/ZA869557B/xx unknown
- 1986-12-19 DK DK619086A patent/DK170346B1/da not_active IP Right Cessation
- 1986-12-20 KR KR1019860011011A patent/KR940005585B1/ko not_active IP Right Cessation
- 1986-12-22 JP JP61306186A patent/JP2575367B2/ja not_active Expired - Lifetime
-
1990
- 1990-09-19 AU AU62683/90A patent/AU637139B2/en not_active Ceased
-
1992
- 1992-03-11 GR GR920400222T patent/GR3003999T3/el unknown
Also Published As
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KR900019561A (ko) | 인체 과립성 백혈구의 콜로니 자극인자 | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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