ES2054771T3 - 1-naftol-ftaleina-monofosfatos, procedimiento para su preparacion asi como su utilizacion para la determinacion de fosfatasa alcalina. - Google Patents

1-naftol-ftaleina-monofosfatos, procedimiento para su preparacion asi como su utilizacion para la determinacion de fosfatasa alcalina.

Info

Publication number
ES2054771T3
ES2054771T3 ES88118800T ES88118800T ES2054771T3 ES 2054771 T3 ES2054771 T3 ES 2054771T3 ES 88118800 T ES88118800 T ES 88118800T ES 88118800 T ES88118800 T ES 88118800T ES 2054771 T3 ES2054771 T3 ES 2054771T3
Authority
ES
Spain
Prior art keywords
determination
monofosfatos
ftaleina
naftol
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88118800T
Other languages
English (en)
Inventor
Werner Dr Rer Nat Guthlein
Hartmut Dr Rer Nat Merdes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2054771T3 publication Critical patent/ES2054771T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/40—Triphenylmethane dye chromogens, e.g. fluorescein derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE REFIERE A NUEVOS 1-NAFTOLFTALEINMONOFOSFATOS ASI COMO A UN PROCESO PARA SU OBTENCION. PARA ESTO SE HACEN REACCIONAR NAFTOLFTALEINAS CON COMPUESTOS DE FOSFORO EN PRESENCIA DE UNA BASE ORGANICA Y, EN SU CASO, SE BROMAN. LOS NUEVOS COMPUESTOS SON SEPARADOS POR FOSFATASAS ALCALINAS Y, SEGUN ESTO, RESULTAN APROPIADAS COMO SUSTRATO PARA LA DETERMINACION DE LA ACTIVIDAD DE FOSFATASAS ALCALINAS. LOS DERIVADOS DE 1-NAFTOLFTALEINA QUE SURGEN COMO PRODUCTOS DE SEPARACION PUEDEN DETERMINARSE FOTOMETRICAMENTE.
ES88118800T 1987-11-20 1988-11-11 1-naftol-ftaleina-monofosfatos, procedimiento para su preparacion asi como su utilizacion para la determinacion de fosfatasa alcalina. Expired - Lifetime ES2054771T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873739284 DE3739284A1 (de) 1987-11-20 1987-11-20 1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase

Publications (1)

Publication Number Publication Date
ES2054771T3 true ES2054771T3 (es) 1994-08-16

Family

ID=6340842

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88118800T Expired - Lifetime ES2054771T3 (es) 1987-11-20 1988-11-11 1-naftol-ftaleina-monofosfatos, procedimiento para su preparacion asi como su utilizacion para la determinacion de fosfatasa alcalina.

Country Status (6)

Country Link
US (1) US4985414A (es)
EP (1) EP0316791B1 (es)
JP (1) JPH01160990A (es)
AT (1) ATE86626T1 (es)
DE (2) DE3739284A1 (es)
ES (1) ES2054771T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2646814B2 (ja) * 1990-08-07 1997-08-27 アイシン精機株式会社 核酸等の検定方法
DE19632432A1 (de) * 1996-08-12 1998-02-19 Boehringer Mannheim Gmbh Stabile Mischung zum Nachweis alkalischer Phosphatase mit einem Salz der o-Kresolphthaleinmonophosphorsäure
BR102013023221B1 (pt) * 2013-09-11 2021-08-17 Universidade Federal Do Rio De Janeiro Processo de síntese de fenolftaleína bisfosfato tetrassódio e kit
WO2016013115A1 (ja) * 2014-07-25 2016-01-28 株式会社 リージャー 希釈生体試料成分の分析方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3331862A (en) * 1964-06-05 1967-07-18 Warner Lambert Pharmaceutical Phenolphthalein-mono-phosphate derivatives
US3331857A (en) * 1964-10-01 1967-07-18 Warner Lambert Pharmaceutical Phenolphthalein monophosphate derivatives
US3823071A (en) * 1970-12-21 1974-07-09 Worthington Biochem Corp Prostatic acid phosphatase determination
US3931228A (en) * 1971-01-21 1976-01-06 Polaroid Corporation Process for preparing phthalide and naphthalide indicator dyes
US4035391A (en) * 1974-02-28 1977-07-12 Polaroid Corporation Phthalide and naphthalide derivatives
US3975405A (en) * 1974-08-01 1976-08-17 Coulter Diagnostics, Inc. Monophosphate salt of o-cresolphthalein
US4032545A (en) * 1975-09-29 1977-06-28 Polaroid Corporation Phthalides and naphthalides

Also Published As

Publication number Publication date
DE3879107D1 (de) 1993-04-15
EP0316791A3 (en) 1990-06-13
DE3739284A1 (de) 1989-06-01
JPH0513958B2 (es) 1993-02-23
JPH01160990A (ja) 1989-06-23
EP0316791A2 (de) 1989-05-24
US4985414A (en) 1991-01-15
EP0316791B1 (de) 1993-03-10
ATE86626T1 (de) 1993-03-15

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