ES2053856T3 - Derivados del acido 4-quinoleino carboxilico utiles para el tratamiento de enfermedades de la piel y del muco-epitelio. - Google Patents

Derivados del acido 4-quinoleino carboxilico utiles para el tratamiento de enfermedades de la piel y del muco-epitelio.

Info

Publication number
ES2053856T3
ES2053856T3 ES89107098T ES89107098T ES2053856T3 ES 2053856 T3 ES2053856 T3 ES 2053856T3 ES 89107098 T ES89107098 T ES 89107098T ES 89107098 T ES89107098 T ES 89107098T ES 2053856 T3 ES2053856 T3 ES 2053856T3
Authority
ES
Spain
Prior art keywords
muco
derivatives
skin
useful
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89107098T
Other languages
English (en)
Inventor
Neil Richard Ackerman
Richard Russell Harris
Scott Edward Loveless
Russell Howard Neubauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Application granted granted Critical
Publication of ES2053856T3 publication Critical patent/ES2053856T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ACIDOS FENILQUINOLINECARBOXILICOS Y DERIVADOS DE ELLOS, TALES COMO 2-(2-FLUORO-1,1-BIFENIL-4-IL)-6-FLUORO-3-METIL-ACIDO QUINOLINECARBOXILICO, O SALES POTASICAS DE ELLOS, SE USAN PARA TRATAMIENTO DE LA PIEL Y MALES MUCOEPITELIALES.
ES89107098T 1988-04-26 1989-04-20 Derivados del acido 4-quinoleino carboxilico utiles para el tratamiento de enfermedades de la piel y del muco-epitelio. Expired - Lifetime ES2053856T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/186,242 US4861783A (en) 1988-04-26 1988-04-26 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases

Publications (1)

Publication Number Publication Date
ES2053856T3 true ES2053856T3 (es) 1994-08-01

Family

ID=22684175

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89107098T Expired - Lifetime ES2053856T3 (es) 1988-04-26 1989-04-20 Derivados del acido 4-quinoleino carboxilico utiles para el tratamiento de enfermedades de la piel y del muco-epitelio.

Country Status (16)

Country Link
US (1) US4861783A (es)
EP (1) EP0339484B1 (es)
JP (1) JP2650756B2 (es)
KR (1) KR0124817B1 (es)
AT (1) ATE84716T1 (es)
AU (1) AU610469B2 (es)
CA (1) CA1336263C (es)
DE (1) DE68904462T2 (es)
DK (1) DK199789A (es)
ES (1) ES2053856T3 (es)
IE (1) IE64285B1 (es)
IL (1) IL90056A (es)
MY (1) MY104006A (es)
NZ (1) NZ228894A (es)
PT (1) PT90362B (es)
ZA (1) ZA893086B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102883A (en) * 1989-10-31 1992-04-07 Du Pont Merck Pharmaceutical Company Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents
US5204329A (en) * 1990-06-11 1993-04-20 Du Pont Merck Pharmaceutical Company Treatment of organ transplantation rejection
US5135934A (en) * 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5281196A (en) * 1992-05-22 1994-01-25 Sultenfuss Thomas J Skin treatment composition and method of use
US5409886A (en) * 1993-02-18 1995-04-25 Mitsui Toatsu Chemicals, Incorporated 3-pyrroline-2-one derivatives and herbicidal compositions containing same
US5578609A (en) * 1994-03-25 1996-11-26 The Dupont Merck Pharmaceutical Company 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
JP2002505689A (ja) 1997-06-19 2002-02-19 セプレイコー インコーポレイテッド キノリン−インドール抗菌剤、それらに関する用途及び組成物
KR101262400B1 (ko) * 2004-12-13 2013-05-08 오노 야꾸힝 고교 가부시키가이샤 아미노카르복실산 유도체 및 그 의약 용도
CA3153463A1 (en) 2012-10-29 2014-05-08 The University Of North Carolina At Chapel Hill Methods and compositions for treating mucosal tissue disorders
EA201691057A1 (ru) 2013-11-22 2016-10-31 Джензим Корпорейшн Новые способы лечения нейродегенеративных заболеваний
CN110198728A (zh) 2016-11-17 2019-09-03 莱诺翁股份有限公司 用谷胱甘肽组合物治疗呼吸道疾病和感染
EP3710036A4 (en) 2017-11-17 2021-07-21 Renovion, Inc. STABLE ASCORBIC ACID COMPOSITIONS AND METHOD FOR THEIR USE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181725A (en) * 1977-05-02 1980-01-01 The Regents Of The University Of Michigan Method for alleviating psoriasis
AU583793B2 (en) * 1983-07-22 1989-05-11 Du Pont Pharmaceuticals Company Phenylquinolinecarboxylic acids and derivatives as antitumor agents
US4680299A (en) * 1984-04-30 1987-07-14 E.I. Du Pont De Nemours And Company 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
US4889862A (en) * 1986-08-28 1989-12-26 E. I. Du Pont De Nemours And Company Freeze-dried pharmaceutical compositions of phenylquinoline carboxylic acids

Also Published As

Publication number Publication date
ZA893086B (en) 1990-12-28
DK199789D0 (da) 1989-04-25
EP0339484A1 (en) 1989-11-02
IE64285B1 (en) 1995-07-26
US4861783A (en) 1989-08-29
DE68904462D1 (de) 1993-03-04
JP2650756B2 (ja) 1997-09-03
MY104006A (en) 1993-10-30
CA1336263C (en) 1995-07-11
JPH0272163A (ja) 1990-03-12
KR0124817B1 (ko) 1997-11-25
EP0339484B1 (en) 1993-01-20
AU3331889A (en) 1989-11-02
IL90056A0 (en) 1989-12-15
IE891329L (en) 1989-10-26
DE68904462T2 (de) 1993-05-13
AU610469B2 (en) 1991-05-16
DK199789A (da) 1989-10-27
KR900016135A (ko) 1990-11-12
NZ228894A (en) 1992-02-25
PT90362A (pt) 1989-11-10
PT90362B (pt) 1994-07-29
ATE84716T1 (de) 1993-02-15
IL90056A (en) 1993-04-04

Similar Documents

Publication Publication Date Title
ES2053856T3 (es) Derivados del acido 4-quinoleino carboxilico utiles para el tratamiento de enfermedades de la piel y del muco-epitelio.
MA21682A1 (fr) Procede de preparation d'agents therapeutiques derives de la quainclidine.
ES515032A0 (es) "proceso para la produccion microbiana de interferon fibroblasto humano".
DK275585A (da) Hidtil ukendte calciumsalte
FR2633929B2 (fr) Derives non toxiques de l'acide n-butyrique, presentant des actions therapeutiques retardees
DE3873855D1 (de) Mischung von cholecalciferol-derivaten fuer die behandlung von nierenbezogenen knochenkrankheiten.
ES2075315T3 (es) Procedimiento para la preparacion de acidos (6s)- y (6r)-tetrahidrofolicos.
IT8947803A0 (it) Procedimento per la produzione di semilavorati di cuoio
ES8507498A1 (es) Un procedimiento para la preparacion de acidos fenilquinolin-carboxilicos.
ES2013631B3 (es) Metodo para el tratamiento de tejidos.
ES2045348T3 (es) Metodo para preparar derivados de lactamimida para el tratamiento o la prevencion de paludismo farmaco-resistente.
MX26167A (es) Derivados de acido piridil-benzoico para el tratamiento de enfermedades relacionadas con lecotrino.
IT8721115A0 (it) Fitopreparato per la cura di affezioni cutanee.
AR228396A1 (es) Metodo para la preparacion de composiciones farmaceuticas para el tratamiento de la piel
ES2135500T3 (es) Producto farmaceutico para el tratamiento de trastornos de la piel.
IT1289528B1 (it) Procedimento per la preparazione dell'acido 13,cis-retinoico
DE58903876D1 (de) Riboflavin-4'5'-cyclo-phosphorsaeureesterchlorid, dessen herstellung und verwendung zur herstellung von riboflavin-5'-phosphat (5'-fmn) bzw. dessen natriumsalz.
ES2020925B3 (es) Nuevas sales cristalinas de ariloxipropanolaminas, procedimiento para su preparacion y utilizacion de las mismas.
ES2053101T3 (es) Compuesto detergente para la piel.
ES516399A0 (es) "procedimiento para la fabricacion de productos farmaceuticos directamente absorbidos por el intestino delgado".
IT8621934A0 (it) Procedimento per la preparazione di derivati salini dell'acido mercaptoetansolfonico.
IT8519297A0 (it) Prodotto per la sostituzione di tessuti corporei.
ES516605A0 (es) "procedimiento para la produccion o tratamiento de ferrocromo".
ES2011472B3 (es) Procedimiento para el tratamiento de soluciones acuosas producidas en la carboxilacion de compuestos olefinicos no saturados.
ES509991A0 (es) "metodo para la produccion continua, semicontinua o intermitente de derivados oxadiazolidinicos".

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 339484

Country of ref document: ES