ES2053401A1 - Imidazole compounds and procedures for the preparation thereof - Google Patents
Imidazole compounds and procedures for the preparation thereofInfo
- Publication number
- ES2053401A1 ES2053401A1 ES09300033A ES9300033A ES2053401A1 ES 2053401 A1 ES2053401 A1 ES 2053401A1 ES 09300033 A ES09300033 A ES 09300033A ES 9300033 A ES9300033 A ES 9300033A ES 2053401 A1 ES2053401 A1 ES 2053401A1
- Authority
- ES
- Spain
- Prior art keywords
- procedures
- preparation
- imidazole compounds
- reaction
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Imidazole compounds and procedures for the preparation thereof, of the general formula < IMAGE > where R1, R2, R3 and R4 represent different organic or inorganic radicals. They are prepared by condensing an alpha-diketone with an aldehyde and subsequent closing of the ring, or by an oxidation reaction of an alpha-hydroxyketone or by the reaction of the latter with an amidine or with an imino ether or the reaction of an amide with a nitrile and an acyl halide. The compounds are used for the treatment of cytokine-mediated diseases.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09300033A ES2053401B1 (en) | 1992-01-13 | 1993-01-12 | IMIDAZOLE COMPOUNDS AND PROCEDURES FOR ITS PREPARATION. |
FR9302441A FR2700331B3 (en) | 1993-01-12 | 1993-03-03 | Nutritious aqueous plant gel containing sodium carboxymethylcellulose. |
PT101273A PT101273A (en) | 1993-01-12 | 1993-05-21 | AQUOSA NUTRIENT GELEI |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81955192A | 1992-01-13 | 1992-01-13 | |
ES09300033A ES2053401B1 (en) | 1992-01-13 | 1993-01-12 | IMIDAZOLE COMPOUNDS AND PROCEDURES FOR ITS PREPARATION. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2053401A1 true ES2053401A1 (en) | 1994-07-16 |
ES2053401B1 ES2053401B1 (en) | 1995-03-01 |
Family
ID=26154686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09300033A Expired - Fee Related ES2053401B1 (en) | 1992-01-13 | 1993-01-12 | IMIDAZOLE COMPOUNDS AND PROCEDURES FOR ITS PREPARATION. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2053401B1 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2221546A1 (en) * | 1971-05-10 | 1972-11-16 | Ciba Geigy Ag | Process for the production of new imidazole derivatives |
US3772441A (en) * | 1970-11-16 | 1973-11-13 | Pfizer | Anti-inflammatory imidazoles |
EP0011111A1 (en) * | 1978-09-27 | 1980-05-28 | Smithkline Beckman Corporation | 5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo-(2,1-b)-thiazole, process for its preparation and medical composition |
WO1993014081A1 (en) * | 1992-01-13 | 1993-07-22 | Smithkline Beecham Corporation | Imidazole derivatives and their use as cytokine inhibitors |
-
1993
- 1993-01-12 ES ES09300033A patent/ES2053401B1/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3772441A (en) * | 1970-11-16 | 1973-11-13 | Pfizer | Anti-inflammatory imidazoles |
DE2221546A1 (en) * | 1971-05-10 | 1972-11-16 | Ciba Geigy Ag | Process for the production of new imidazole derivatives |
EP0011111A1 (en) * | 1978-09-27 | 1980-05-28 | Smithkline Beckman Corporation | 5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo-(2,1-b)-thiazole, process for its preparation and medical composition |
WO1993014081A1 (en) * | 1992-01-13 | 1993-07-22 | Smithkline Beecham Corporation | Imidazole derivatives and their use as cytokine inhibitors |
Also Published As
Publication number | Publication date |
---|---|
ES2053401B1 (en) | 1995-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD2A | Announcement of lapse in spain |
Effective date: 20110223 |