ES2053401A1 - Imidazole compounds and procedures for the preparation thereof - Google Patents

Imidazole compounds and procedures for the preparation thereof

Info

Publication number
ES2053401A1
ES2053401A1 ES09300033A ES9300033A ES2053401A1 ES 2053401 A1 ES2053401 A1 ES 2053401A1 ES 09300033 A ES09300033 A ES 09300033A ES 9300033 A ES9300033 A ES 9300033A ES 2053401 A1 ES2053401 A1 ES 2053401A1
Authority
ES
Spain
Prior art keywords
procedures
preparation
imidazole compounds
reaction
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09300033A
Other languages
Spanish (es)
Other versions
ES2053401B1 (en
Inventor
Timothy Francis Gallagher
Jerry Leroy Adams
John C Lee
John Richard White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Priority to ES09300033A priority Critical patent/ES2053401B1/en
Priority to FR9302441A priority patent/FR2700331B3/en
Priority to PT101273A priority patent/PT101273A/en
Publication of ES2053401A1 publication Critical patent/ES2053401A1/en
Application granted granted Critical
Publication of ES2053401B1 publication Critical patent/ES2053401B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Imidazole compounds and procedures for the preparation thereof, of the general formula < IMAGE > where R1, R2, R3 and R4 represent different organic or inorganic radicals. They are prepared by condensing an alpha-diketone with an aldehyde and subsequent closing of the ring, or by an oxidation reaction of an alpha-hydroxyketone or by the reaction of the latter with an amidine or with an imino ether or the reaction of an amide with a nitrile and an acyl halide. The compounds are used for the treatment of cytokine-mediated diseases.
ES09300033A 1992-01-13 1993-01-12 IMIDAZOLE COMPOUNDS AND PROCEDURES FOR ITS PREPARATION. Expired - Fee Related ES2053401B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES09300033A ES2053401B1 (en) 1992-01-13 1993-01-12 IMIDAZOLE COMPOUNDS AND PROCEDURES FOR ITS PREPARATION.
FR9302441A FR2700331B3 (en) 1993-01-12 1993-03-03 Nutritious aqueous plant gel containing sodium carboxymethylcellulose.
PT101273A PT101273A (en) 1993-01-12 1993-05-21 AQUOSA NUTRIENT GELEI

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81955192A 1992-01-13 1992-01-13
ES09300033A ES2053401B1 (en) 1992-01-13 1993-01-12 IMIDAZOLE COMPOUNDS AND PROCEDURES FOR ITS PREPARATION.

Publications (2)

Publication Number Publication Date
ES2053401A1 true ES2053401A1 (en) 1994-07-16
ES2053401B1 ES2053401B1 (en) 1995-03-01

Family

ID=26154686

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09300033A Expired - Fee Related ES2053401B1 (en) 1992-01-13 1993-01-12 IMIDAZOLE COMPOUNDS AND PROCEDURES FOR ITS PREPARATION.

Country Status (1)

Country Link
ES (1) ES2053401B1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2221546A1 (en) * 1971-05-10 1972-11-16 Ciba Geigy Ag Process for the production of new imidazole derivatives
US3772441A (en) * 1970-11-16 1973-11-13 Pfizer Anti-inflammatory imidazoles
EP0011111A1 (en) * 1978-09-27 1980-05-28 Smithkline Beckman Corporation 5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo-(2,1-b)-thiazole, process for its preparation and medical composition
WO1993014081A1 (en) * 1992-01-13 1993-07-22 Smithkline Beecham Corporation Imidazole derivatives and their use as cytokine inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3772441A (en) * 1970-11-16 1973-11-13 Pfizer Anti-inflammatory imidazoles
DE2221546A1 (en) * 1971-05-10 1972-11-16 Ciba Geigy Ag Process for the production of new imidazole derivatives
EP0011111A1 (en) * 1978-09-27 1980-05-28 Smithkline Beckman Corporation 5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo-(2,1-b)-thiazole, process for its preparation and medical composition
WO1993014081A1 (en) * 1992-01-13 1993-07-22 Smithkline Beecham Corporation Imidazole derivatives and their use as cytokine inhibitors

Also Published As

Publication number Publication date
ES2053401B1 (en) 1995-03-01

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Effective date: 20110223