ES2052559T3 - Procedimiento para preparar heparina de bajo peso molecular. - Google Patents
Procedimiento para preparar heparina de bajo peso molecular.Info
- Publication number
- ES2052559T3 ES2052559T3 ES87303835T ES87303835T ES2052559T3 ES 2052559 T3 ES2052559 T3 ES 2052559T3 ES 87303835 T ES87303835 T ES 87303835T ES 87303835 T ES87303835 T ES 87303835T ES 2052559 T3 ES2052559 T3 ES 2052559T3
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- molecular weight
- lmw
- depolymerization
- low molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
LA INVENCION TRATA DE UN METODO PARA LA PRODUCCION DE HEPARINA DE BAJO PESO MOLECULAR (HEPARINA BPM) POR DESPOLIMERIZACION ENZIMATICA DE HEPARINA CON HEPARINASA, QUE SE CARACTERIZA PORQUE LA HEPARINA ES ALIMENTADA DE FORMA CONTINUA A LA ZONA DE DESPOLIMERIZACION, LA HEPARINA-BPM DESPOLIMERIZADA SE SOMETE A ULTRAFILTRACION, LA PORCION RETENIDA SE RECICLA A LA ZONA DE DESPOLIMERIZACION Y LA HEPARINA BPM SE RECUPERA DEL FILTRADO. EL PROCESO PERMITE PRODUCIR HEPARINA BPM CON EL PESO MOLECULAR QUE SE DESEE Y POLIDISPERSIDAD BAJA DENTRO DE LIMITES ESTRECHOS POR COMPROBACION CONTINUA O FRECUENTE DEL PESO MOLECULAR Y LA POLIDISPERSIDAD DE LA HEPARINA PRODUCIDA Y CORRECCION DE LOS PARAMETROS DEL PROCESO DE DESPOLIMERIZACION A FIN DE COMPENSAR LAS DESVIACIONES PRODUCIDAS EN LOS PARAMETROS CITADOS CON RELACION A LOS VALORES DESEADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK196886A DK196886D0 (da) | 1986-04-30 | 1986-04-30 | Fremstilling af polysaccharider |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2052559T3 true ES2052559T3 (es) | 1994-07-16 |
Family
ID=8109192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87303835T Expired - Lifetime ES2052559T3 (es) | 1986-04-30 | 1987-04-29 | Procedimiento para preparar heparina de bajo peso molecular. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0244235B1 (es) |
JP (1) | JPS62283102A (es) |
AT (1) | ATE84801T1 (es) |
AU (1) | AU585709B2 (es) |
CA (1) | CA1334080C (es) |
DE (1) | DE3783644T2 (es) |
DK (1) | DK196886D0 (es) |
ES (1) | ES2052559T3 (es) |
FI (1) | FI89943C (es) |
GR (1) | GR3006929T3 (es) |
IE (1) | IE60409B1 (es) |
NO (1) | NO167577C (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK196986D0 (da) * | 1986-04-30 | 1986-04-30 | Novo Industri As | Fremstilling af polysaccharider |
FR2663639B1 (fr) * | 1990-06-26 | 1994-03-18 | Rhone Poulenc Sante | Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation. |
USRE38743E1 (en) | 1990-06-26 | 2005-06-14 | Aventis Pharma S.A. | Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events |
US5707973A (en) * | 1991-04-23 | 1998-01-13 | Rhone-Poulenc Rorer S.A. | Sulfated polysaccharids for treatment or prevention of thromboses |
FR2675806B1 (fr) * | 1991-04-23 | 1994-06-10 | Rhone Poulenc Rorer Sa | Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation. |
US6001820A (en) * | 1995-03-31 | 1999-12-14 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5763427A (en) * | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
ES2230624T5 (es) * | 1996-11-27 | 2010-10-25 | Aventis Pharmaceuticals Inc. | Composicion farmaceutica que comprende un compuesto que tiene actividad anti-xa y un compuesto antagonista de la agregacion plaquetaria. |
CA2293595A1 (en) * | 1997-06-06 | 1998-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Modified low molecular weight heparin that inhibits clot associated coagulation factors |
AU782661B2 (en) * | 1999-06-30 | 2005-08-18 | Hamilton Civic Hospitals Research Development, Inc. | Heparin compositions that inhibit clot associated coagulation factors |
AU2003225724A1 (en) | 2002-03-11 | 2003-09-29 | Momenta Pharmaceuticals, Inc. | Analysis of sulfated polysaccharides |
EP1582531A1 (en) * | 2004-03-24 | 2005-10-05 | Aventis Pharma S.A. | Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products |
ATE552004T1 (de) | 2005-11-30 | 2012-04-15 | Istituto G Ronzoni | Oral verabreichbare heparinderivate |
US9139876B1 (en) | 2007-05-03 | 2015-09-22 | Momenta Pharmacueticals, Inc. | Method of analyzing a preparation of a low molecular weight heparin |
CN102791742B (zh) | 2010-01-19 | 2014-12-24 | 动量制药公司 | 评价肝素制剂 |
US9068957B2 (en) | 2011-02-21 | 2015-06-30 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
CN102690862B (zh) * | 2012-06-08 | 2015-01-28 | 上海太阳生物技术有限公司 | 抗凝血酶ⅲ(at-ⅲ)测定试剂盒(发色底物法) |
WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
EP3997238A1 (en) | 2019-07-09 | 2022-05-18 | Optimvia, LLC | Methods for synthesizing anticoagulant polysaccharides |
CN111763702A (zh) * | 2020-07-13 | 2020-10-13 | 福州大学 | 一种制备硫酸乙酰肝素寡糖的方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4351938A (en) * | 1980-05-19 | 1982-09-28 | Riker Laboratories, Inc. | Anticoagulant substance |
US4396762A (en) * | 1981-08-24 | 1983-08-02 | Massachusetts Institute Of Technology | Heparinase derived anticoagulants |
DE3244214A1 (de) * | 1982-11-30 | 1984-05-30 | B. Braun Melsungen Ag, 3508 Melsungen | Verfahren zur reinigung und fraktionierung von heparin |
DK196986D0 (da) * | 1986-04-30 | 1986-04-30 | Novo Industri As | Fremstilling af polysaccharider |
-
1986
- 1986-04-30 DK DK196886A patent/DK196886D0/da not_active Application Discontinuation
-
1987
- 1987-04-29 AT AT87303835T patent/ATE84801T1/de not_active IP Right Cessation
- 1987-04-29 ES ES87303835T patent/ES2052559T3/es not_active Expired - Lifetime
- 1987-04-29 NO NO871784A patent/NO167577C/no not_active IP Right Cessation
- 1987-04-29 DE DE8787303835T patent/DE3783644T2/de not_active Expired - Fee Related
- 1987-04-29 FI FI871909A patent/FI89943C/fi not_active IP Right Cessation
- 1987-04-29 EP EP87303835A patent/EP0244235B1/en not_active Expired - Lifetime
- 1987-04-30 JP JP62104845A patent/JPS62283102A/ja active Granted
- 1987-04-30 CA CA000536095A patent/CA1334080C/en not_active Expired - Fee Related
- 1987-04-30 AU AU72253/87A patent/AU585709B2/en not_active Ceased
- 1987-05-11 IE IE115287A patent/IE60409B1/en not_active IP Right Cessation
-
1993
- 1993-01-28 GR GR930400176T patent/GR3006929T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO871784D0 (no) | 1987-04-29 |
EP0244235A3 (en) | 1988-09-28 |
FI89943B (fi) | 1993-08-31 |
NO167577C (no) | 1991-11-20 |
EP0244235B1 (en) | 1993-01-20 |
IE871152L (en) | 1987-10-30 |
NO871784L (no) | 1987-11-02 |
AU585709B2 (en) | 1989-06-22 |
JPS62283102A (ja) | 1987-12-09 |
CA1334080C (en) | 1995-01-24 |
FI89943C (fi) | 1993-12-10 |
GR3006929T3 (es) | 1993-06-30 |
DE3783644T2 (de) | 1993-05-13 |
IE60409B1 (en) | 1994-07-13 |
FI871909A (fi) | 1987-10-31 |
AU7225387A (en) | 1987-11-05 |
DK196886D0 (da) | 1986-04-30 |
DE3783644D1 (de) | 1993-03-04 |
ATE84801T1 (de) | 1993-02-15 |
JPH0542918B2 (es) | 1993-06-30 |
NO167577B (no) | 1991-08-12 |
EP0244235A2 (en) | 1987-11-04 |
FI871909A0 (fi) | 1987-04-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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