ES2051479T3 - Uso de imidazoles substituidos en 4 para disminuir la presion intraocular. - Google Patents

Uso de imidazoles substituidos en 4 para disminuir la presion intraocular.

Info

Publication number
ES2051479T3
ES2051479T3 ES90312327T ES90312327T ES2051479T3 ES 2051479 T3 ES2051479 T3 ES 2051479T3 ES 90312327 T ES90312327 T ES 90312327T ES 90312327 T ES90312327 T ES 90312327T ES 2051479 T3 ES2051479 T3 ES 2051479T3
Authority
ES
Spain
Prior art keywords
intraocular pressure
decrease intraocular
imidazoles substituted
imidazoles
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90312327T
Other languages
English (en)
Inventor
Risto Lammintausta
Arto Karjalainen
Ewen Macdonald
Arto Urtti
Raimo Virtanen
Thomas Yorio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898925618A external-priority patent/GB8925618D0/en
Priority claimed from GB898928288A external-priority patent/GB8928288D0/en
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Application granted granted Critical
Publication of ES2051479T3 publication Critical patent/ES2051479T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPUESTOS DE LA FORMULA: AQUI X ES SUB 3) 1, R SUB 2 Y R SUB 3 QUE PUEDEN SER IGUALES O DIFERENTES, SON CADA H O CH SUB 3, UN ESTEROISOMERO O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO; Y COMPUESTOS FARMACEUTICOS QUE LOS CONTENGAN, SON UTILES PARA DISMINUIR LA PRESION INTRAOCULAR EN UN MAMIFERO, POR EJEMPLO, PARA EL TRATAMIENTO DEL GLAUCOMA.
ES90312327T 1989-11-13 1990-11-12 Uso de imidazoles substituidos en 4 para disminuir la presion intraocular. Expired - Lifetime ES2051479T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898925618A GB8925618D0 (en) 1989-11-13 1989-11-13 Compositions and their use in lowering intraocular pressur
GB898928288A GB8928288D0 (en) 1989-12-14 1989-12-14 Compositions and their use in lowering intraocular pressure

Publications (1)

Publication Number Publication Date
ES2051479T3 true ES2051479T3 (es) 1994-06-16

Family

ID=26296200

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90312327T Expired - Lifetime ES2051479T3 (es) 1989-11-13 1990-11-12 Uso de imidazoles substituidos en 4 para disminuir la presion intraocular.

Country Status (12)

Country Link
US (1) US5304569A (es)
EP (1) EP0437030B1 (es)
JP (1) JP3005035B2 (es)
AT (1) ATE104145T1 (es)
AU (1) AU624031B2 (es)
CA (1) CA2029657C (es)
DE (1) DE69008142T2 (es)
DK (1) DK0437030T3 (es)
ES (1) ES2051479T3 (es)
HU (1) HU207443B (es)
IE (1) IE64064B1 (es)
NZ (1) NZ236034A (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9111732D0 (en) * 1991-05-31 1991-07-24 Orion Yhtymae Oy The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
EP2320911B1 (en) 2008-08-01 2014-10-08 Eye Therapies LLC Vasoconstriction compositions and methods of use
US20100203165A1 (en) * 2008-08-01 2010-08-12 Gerald Horn Compositions and methods for treatment of disorders or conditions of the eye
US8952011B2 (en) 2008-08-01 2015-02-10 Eye Therapies Llc Compositions and methods for the treatment of nasal conditions
US8987270B2 (en) 2009-07-27 2015-03-24 Eye Therapies Llc Formulations of selective alpha-2 agonists and methods of use thereof
US20110152271A1 (en) * 2009-12-17 2011-06-23 Gerald Horn Compositions and methods for ophthalmic delivery of nasal decongestants
US8445526B2 (en) 2011-02-03 2013-05-21 Glaucoma & Nasal Therapies Llc Compositions and methods for treatment of glaucoma
US20120202863A1 (en) * 2011-02-03 2012-08-09 Gerald Horn Compositions and methods for treatment of glaucoma
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
WO2013115844A1 (en) 2012-02-02 2013-08-08 Alpha Synergy Development, Inc. Compositions and methods for treatment of glaucoma
US8999938B2 (en) 2013-06-21 2015-04-07 Gnt Llc Ophthalmic lipophilic drug delivery vehicle formulations
KR101827980B1 (ko) 2013-10-07 2018-02-13 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
KR101831290B1 (ko) 2013-10-07 2018-02-22 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 조성물을 사용하여 주의력 결핍 과잉행동 장애, 불안 및 불면증을 치료하기 위한 방법 및 조성물
ES2847936T3 (es) 2013-10-07 2021-08-04 Teikoku Pharma Usa Inc Métodos y composiciones para el suministro transdérmico de una cantidad no sedante de dexmedetomidina
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
CA1201066A (en) * 1981-11-20 1986-02-25 Alcon Laboratories, Inc. N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure
FR2549049B1 (fr) * 1983-07-13 1986-06-20 Chauvin Blache Lab Nouvelles amidines, leur procede de preparation et leur application therapeutique

Also Published As

Publication number Publication date
HU207443B (en) 1993-04-28
CA2029657A1 (en) 1991-05-14
EP0437030B1 (en) 1994-04-13
NZ236034A (en) 1993-03-26
JPH03170423A (ja) 1991-07-24
DE69008142D1 (de) 1994-05-19
ATE104145T1 (de) 1994-04-15
IE64064B1 (en) 1995-07-12
HUT56351A (en) 1991-08-28
IE904069A1 (en) 1991-05-22
AU624031B2 (en) 1992-05-28
JP3005035B2 (ja) 2000-01-31
DK0437030T3 (da) 1994-05-16
HU907099D0 (en) 1991-05-28
DE69008142T2 (de) 1994-07-21
US5304569A (en) 1994-04-19
AU6652390A (en) 1991-05-16
EP0437030A3 (en) 1991-10-30
CA2029657C (en) 2002-06-18
EP0437030A2 (en) 1991-07-17

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