ES2045052T3 - Antagonistas de leucotrienos ltd4 y ltb4. - Google Patents

Antagonistas de leucotrienos ltd4 y ltb4.

Info

Publication number
ES2045052T3
ES2045052T3 ES88115671T ES88115671T ES2045052T3 ES 2045052 T3 ES2045052 T3 ES 2045052T3 ES 88115671 T ES88115671 T ES 88115671T ES 88115671 T ES88115671 T ES 88115671T ES 2045052 T3 ES2045052 T3 ES 2045052T3
Authority
ES
Spain
Prior art keywords
low
ltd4
antagonists
alkyl
fenilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88115671T
Other languages
English (en)
Inventor
James Ronald Deason
Michael Allan Stealey
Richard Mathias Weier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/100,685 external-priority patent/US4808729A/en
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2045052T3 publication Critical patent/ES2045052T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ESTA INVENCION COM''PRENDE COMPUESTOS DE LA FORMULA(I), Y SUS SALES ACEPTABLES FARMACEUTICAMENTE Y LOS ISOMEROS OPTICOS Y GEOMETRICOS DEL MISMO DONDE, X, Y Y Z SON INDEPENDIENTEMENTE O O S CON S OXIDADO OPCIONALMENTE A S = O; ALK ES UNA CADENA LINEAL O RAMIFICADA ALQUILENO O HIDROXIALQUILENO QUE CONTIENE DE 1 A 6 ATOMOS DE CARBONO; R1 ES H O BAJO ALQUILO; N ES 0 A 5; R2 ES H, BAJO ALQUILO, CICLOALQUILO - (CH2)N - CO2R1, FENILO, FENILO SUSTITUIDO CON HALO, BAJO ALQUILO O BAJO ALCOXILO; Y AR ES 5,6,7,8 - TETRAHIDRO - 1 - NAFTANILO, FENILO, O FENILO SUSTITUIDO CON BAJO ALQUILO, HIDROXILO, BAJO ALCOXILO O BAJO ALCANOILO. ESTA INVENCION ESTA EN EL CAMPO DE LOS AGENTES FARMACEUTICOS QUE ACTUAN COMO LEUCOTRIENOS D4(LTD4) ANTAGONISTAS E INCLUYE B4(LTD4) ANTAGONISTAS.
ES88115671T 1987-09-24 1988-09-23 Antagonistas de leucotrienos ltd4 y ltb4. Expired - Lifetime ES2045052T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/100,685 US4808729A (en) 1987-09-24 1987-09-24 Leukotriene LTD4 and LTB4 antagonists
US07/241,265 US4923891A (en) 1987-09-24 1988-09-09 Leukotriene LTD4 and LTB4 antagonists

Publications (1)

Publication Number Publication Date
ES2045052T3 true ES2045052T3 (es) 1994-01-16

Family

ID=26797440

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88115671T Expired - Lifetime ES2045052T3 (es) 1987-09-24 1988-09-23 Antagonistas de leucotrienos ltd4 y ltb4.

Country Status (14)

Country Link
US (1) US4923891A (es)
EP (1) EP0308956B1 (es)
JP (1) JPH01132577A (es)
KR (1) KR890005082A (es)
AU (1) AU610246B2 (es)
DE (1) DE3878806T2 (es)
DK (1) DK530888A (es)
ES (1) ES2045052T3 (es)
FI (1) FI884377A (es)
GR (1) GR3007858T3 (es)
IL (1) IL87800A (es)
NO (1) NO171412C (es)
NZ (1) NZ226318A (es)
PT (1) PT88580B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5579409A (en) * 1991-09-27 1996-11-26 E. I. Du Pont De Nemours And Company Methods for determining the exterior points of an object in a background
EP0833664A1 (en) 1995-06-12 1998-04-08 G.D. SEARLE & CO. Combination of a cyclooxygenase-2 inhibitor and a leukotriene b 4? receptor antagonist for the treatment of inflammations
AU2250097A (en) * 1996-02-13 1997-09-02 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist
DE69911020T2 (de) * 1999-10-06 2004-07-08 Dainippon Ink And Chemicals, Inc. 4-Methylen-1,3-dioxolane mit funktionellen Gruppen
US6664287B2 (en) * 2000-03-15 2003-12-16 Bethesda Pharmaceuticals, Inc. Antioxidants
PL1954140T3 (pl) 2005-11-22 2013-08-30 Segetis Inc Ketale lewulinianu glicerolu i ich zastosowanie
CN104478844B (zh) * 2007-10-09 2018-12-04 Gf 生物化学知识产权资产有限公司 制备缩酮和乙缩醛的方法
CN102239156B (zh) 2008-09-25 2014-10-15 塞格提斯有限公司 缩酮酯衍生物
KR101808867B1 (ko) 2009-06-22 2018-01-18 세게티스, 인코포레이티드. 케탈 화합물 및 이의 용도
KR20130102460A (ko) 2010-05-10 2013-09-17 세게티스, 인코포레이티드. 알킬 케탈 에스터를 함유하는 퍼스널 케어 조제물 및 제조방법
EP2601184B1 (en) 2010-08-03 2015-12-16 Segetis, Inc. Methods for the manufacture of ketals
BR112013002991A2 (pt) 2010-08-12 2016-08-16 Segetis Inc composições de revestimento de látex incluindo carboxiéster cetal coalescentes, métodos de fabricação e usos dos mesmos
AU2011289224B2 (en) 2010-08-12 2015-04-16 Gfbiochemicals Limited Carboxy ester ketal removal compositions, methods of manufacture, and uses thereof
US8632612B2 (en) 2010-09-07 2014-01-21 Segetis, Inc. Compositions for dyeing keratin fibers
WO2012037122A2 (en) 2010-09-13 2012-03-22 Segetis, Inc. Fabric softener compositions and methods of manufacture thereof
CN103154158B (zh) 2010-10-18 2017-04-05 Gf生化有限公司 包含羧基酯缩酮的水可稀释型涂料组合物、其生产方法和用途
WO2014047428A1 (en) 2012-09-21 2014-03-27 Segetis, Inc. Cleaning, surfactant, and personal care compositions
AU2013352172A1 (en) 2012-11-29 2015-06-11 Gfbiochemicals Limited Carboxy ester ketals, methods of manufacture, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2839445A (en) * 1954-01-11 1958-06-17 Du Pont Fungicidal and anti-oxidant compositions comprising 1, 3-dithiolanes
FR4493M (es) * 1964-07-09 1966-10-10
FR1445013A (fr) * 1964-07-09 1966-07-08 Thomae Gmbh Dr K Procédé pour fabriquer des nouveaux acides dioxolano-2-carboxyliques
FR1448340A (fr) * 1964-07-09 1966-08-05 Boehringer Sohn Ingelheim Procédé pour fabriquer des nouveaux 1, 3-dioxolanes
GB1427918A (en) * 1972-05-26 1976-03-10 Shell Int Research Herbicidal glycerol acetals
FR2577552B1 (fr) * 1985-02-20 1987-09-04 Sori Soc Rech Ind Esters heterocycliques dissymetriques d'acides 1,4-dihydropyridine-3,5-dicarboxyliques, procede de preparation et utilisation en therapeutique

Also Published As

Publication number Publication date
NO884223D0 (no) 1988-09-23
NO884223L (no) 1989-03-28
AU2274188A (en) 1989-04-06
FI884377A (fi) 1989-03-25
PT88580A (pt) 1988-10-01
IL87800A0 (en) 1989-03-31
FI884377A0 (fi) 1988-09-23
NZ226318A (en) 1991-08-27
EP0308956A3 (en) 1990-06-13
GR3007858T3 (es) 1993-08-31
PT88580B (pt) 1992-11-30
AU610246B2 (en) 1991-05-16
NO171412C (no) 1993-03-10
EP0308956A2 (en) 1989-03-29
NO171412B (no) 1992-11-30
US4923891A (en) 1990-05-08
EP0308956B1 (en) 1993-03-03
DE3878806T2 (de) 1993-07-01
DK530888A (da) 1989-03-25
DE3878806D1 (de) 1993-04-08
KR890005082A (ko) 1989-05-11
JPH01132577A (ja) 1989-05-25
IL87800A (en) 1992-12-01
DK530888D0 (da) 1988-09-23

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