ES2031477T3 - Procedimiento para producir esteres de acido 1-hidroxi-5-oxo-5h-pirido/3,2-a/fenoxazin-3-carboxilico. - Google Patents

Procedimiento para producir esteres de acido 1-hidroxi-5-oxo-5h-pirido/3,2-a/fenoxazin-3-carboxilico.

Info

Publication number
ES2031477T3
ES2031477T3 ES198787110051T ES87110051T ES2031477T3 ES 2031477 T3 ES2031477 T3 ES 2031477T3 ES 198787110051 T ES198787110051 T ES 198787110051T ES 87110051 T ES87110051 T ES 87110051T ES 2031477 T3 ES2031477 T3 ES 2031477T3
Authority
ES
Spain
Prior art keywords
pirido
phenoxazin
oxo
hydroxy
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787110051T
Other languages
English (en)
Inventor
Hideo Terayama
Jun Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2031477T3 publication Critical patent/ES2031477T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LOS COMPUESTOS REPRESENTADOS POR LA FORMULA GENERAL (I) EN LA QUE R ES UN GRUPO ALQUILO QUE TIENE DE 1 A 10 ATOMOS DE CARBONO SON NUEVOS COMPUESTOS SOBRE LOS QUE NO SE HA INFORMADO EN LA BIBLIOGRAFIA. COMO ESTOS TIENEN EXCELENTES AFINIDADES PARA LOS TEJIDOS CON UNA PERMEABILIDAD CORNEAL PARTICULARMENTE ALTA Y MUESTRAN ACTIVIDAD ANTICATARATA A BAJA CONCENTRACION, LOS COMPUESTOS SON VALIOSOS COMO AGENTES PROFILACTICOS Y TERAPEUTICOS PARA LA CATARATAS.
ES198787110051T 1986-07-15 1987-07-11 Procedimiento para producir esteres de acido 1-hidroxi-5-oxo-5h-pirido/3,2-a/fenoxazin-3-carboxilico. Expired - Lifetime ES2031477T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61166066A JPS6322584A (ja) 1986-07-15 1986-07-15 １−ハイドロキシ−５−オキソ−５Ｈ−ピリド〔３，２−ａ〕フエノキサジン−３−カルボン酸エステル類

Publications (1)

Publication Number Publication Date
ES2031477T3 true ES2031477T3 (es) 1992-12-16

Family

ID=15824343

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787110051T Expired - Lifetime ES2031477T3 (es) 1986-07-15 1987-07-11 Procedimiento para producir esteres de acido 1-hidroxi-5-oxo-5h-pirido/3,2-a/fenoxazin-3-carboxilico.

Country Status (12)

Country Link
US (1) US4820837A (es)
EP (1) EP0254167B1 (es)
JP (1) JPS6322584A (es)
KR (1) KR950008316B1 (es)
CN (1) CN1019299B (es)
AT (1) ATE58141T1 (es)
CA (1) CA1311477C (es)
DE (1) DE3766028D1 (es)
ES (1) ES2031477T3 (es)
GR (1) GR3001065T3 (es)
HU (1) HU196211B (es)
SU (1) SU1628858A3 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU635045B2 (en) * 1989-07-20 1993-03-11 Asai Germanium Research Institute Co., Ltd Agent for preventing and treating opacity of lens
CN108558906A (zh) * 2018-05-21 2018-09-21 日照市普达医药科技有限公司 一种治疗白内障药物苯并吩噁嗪类化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59520B2 (ja) * 1974-07-19 1984-01-07 センジユセイヤク カブシキガイシヤ １− ハイドロキシ −５− オキソ −５ｈ− ピリド （ ３，２−ａ ） フエノキサジン −３− カルボンサン オヨビ ソノユウドウタイノセイセイホウ
JPS5270014A (en) * 1975-12-05 1977-06-10 Senju Pharma Co Stabilization of pyrido*3*22a*phenoxadine compounds
SE448091B (sv) * 1977-12-15 1987-01-19 Roussel Uclaf Nya 2-/(4-kinolinyl)-amino/-5-fluorbensoesyraderivat, forfarande for framstellning derav samt farmaceutiska kompositioner innehallande dessa derivat
US4369184A (en) * 1980-01-24 1983-01-18 Janssen Pharmaceutica N.V. 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Also Published As

Publication number Publication date
GR3001065T3 (en) 1992-03-20
CN1019299B (zh) 1992-12-02
KR880001666A (ko) 1988-04-26
JPH0236596B2 (es) 1990-08-17
SU1628858A3 (ru) 1991-02-15
EP0254167A1 (en) 1988-01-27
JPS6322584A (ja) 1988-01-30
US4820837A (en) 1989-04-11
HU196211B (en) 1988-10-28
ATE58141T1 (de) 1990-11-15
KR950008316B1 (ko) 1995-07-27
CN87104927A (zh) 1988-02-03
CA1311477C (en) 1992-12-15
HUT45062A (en) 1988-05-30
EP0254167B1 (en) 1990-11-07
DE3766028D1 (de) 1990-12-13

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